The Effect of Vaccine Type and SARS-CoV-2 Lineage on Commercial SARS-CoV-2 Serologic and Pseudotype Neutralization Assays in mRNA Vaccine RecipientsmRNA 백신 수혜자의 상업용 SARS-CoV-2 혈청학적 및 유사형 중화 분석에 대한 백신 유형 및 SARS-CoV-2 계통의 효과Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] affected Alpha anti-S anti-S antibody Anti-SARS-CoV-2 S Anti-spike anti-spike antibodies anti-spike antibody Antibody testing approach association Beta Beta variant BNT162b2 CDC Characteristics Cohort collected Concentration correlated correlation COVID-19 infection Day determine difficulty Effect Elecsy enrolled epidemiological evaluated Gamma healthy Immunity immunity after vaccination immunogenicity individuals Interpretation interval Level Lower marker mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-1273 vaccine Neutralization assay Neutralizing activity neutralizing antibody neutralizing titers pseudotype receiving recipient recipients recommendation recruited Roche SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants serologic serologic assay serologic assays serology serum significantly higher Support surrogate Type vaccinated individual vaccination Vaccine variable variant were measured wild-type WT strain [DOI] 10.1128/spectrum.00211-22 PMC 바로가기 [Article Type] Article
Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion중화 단일 클론 항체는 막 융합 차단을 통해 SARS-CoV-2 감염을 억제합니다Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antigenic epitope Antisera blocking cell membrane collected conserved COVID-19 therapeutics Delta Effectiveness epitope epitope peptide Epitopes Epsilon exhibited fusion Gamma immunized immunodominant Infection inhibit SARS-CoV-2 inhibited membrane membrane fusion mice MOST Mutation NAb NAbs Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody peptides Protein RBD RBD sequence RBD sequences Receptor binding Receptor binding domain reduced S protein S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-like coronaviruses sequence spike (S) protein the RBD the S protein the SARS-CoV-2 unique Vaccine Vaccines variants virus virus entry [DOI] 10.1128/spectrum.01814-21 PMC 바로가기 [Article Type] Article
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concernResearch Articles Published on 2022-04-262022-10-04 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2-binding site animal models antibody antigenic diversity antigenic site Beta concern conserved COVID-19 Cryo-electron microscopy Delta description domain effective epitope Evolution of SARS-CoV-2 experiments Gamma hamster Human monoclonal antibody hydrophobic residue Immune escape in vitro mice monoclonal antibody Mutation neutralization neutralization capacity Neutralizing activity omicron pandemic Prophylactic prophylactically Protective receptor binding site retained SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants site-directed mutagenesis target the S protein the spike protein therapeutic therapeutic activity VOCs [DOI] 10.1126/sciimmunol.abp9312 PMC 바로가기 [Article Type] Research Articles
Longitudinal Analysis of Coronavirus-Neutralizing Activity in COVID-19 PatientsCOVID-19 환자의 코로나바이러스 중화 활성에 대한 종단 분석Article Published on 2022-04-232022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition alpha-coronavirus cardiovascular system cause characterized common cold Coronavirus-2 COVID-19 COVID-19 patient Delta detectable disease Germany humoral immune response immune responses induce Infection longitudinal mRNA vaccine neutralization neutralization activity Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody NL63 occurred omicron pandemic recovered patient recovered patients respiratory SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 neutralization activity serum Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity subset university vaccination waned wild-type [DOI] 10.3390/v14050882 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccineSARS-CoV-2 오미크론 중화 기억 B 세포는 BNT162b2 mRNA 백신 2회 투여에 의해 유발됩니다Article Published on 2022-04-222022-09-11 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody Antibody binding B cell Beta BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine booster breadth Breakthrough infection Cell cellular dose elicited evade fraction help IMPROVE in vitro mechanism memory B memory B cell memory B cells mRNA vaccine Multiple Mutation Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody of BNT162b2 omicron phenotype plasma RBD RBD-binding IgG recall receptor Receptor binding domain SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants second dose secreted Spike receptor binding domain stimulated subset vaccinated individuals vaccination vaccine dose variant [DOI] 10.1126/sciimmunol.abn8590 PMC 바로가기 [Article Type] Article
Cocktail of REGN Antibodies Binds More Strongly to SARS-CoV-2 Than Its Components, but the Omicron Variant Reduces Its Neutralizing AbilityREGN 항체 칵테일은 성분보다 SARS-CoV-2에 더 강하게 결합하지만 오미크론 변이체는 중화 능력을 감소시킵니다Article Published on 2022-04-212022-09-11 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Ability antibody antiviral antibodies antiviral antibody appear approach association bind binding calculated change coarse-grained simulation coarse-grained simulations cocktail complexes components computational method contribute COVID-19 infections Delta delta variant dissociation constants driven by effective Effectiveness electrostatic interaction electrostatic interactions Infection Interaction interactions K417N molecular molecular dynamics molecular mechanism molecular mechanisms Mutation neutralize Neutralizing activity omicron Omicron variant RBD Receptor-binding domain reduce REGN10933 REGN10987 SARS-CoV-2 SARS-CoV-2 spike protein shown Spike protein Structure structures the receptor-binding domain the SARS-CoV-2 Treatment treatment of COVID-19 understanding van der Waal van der Waals interactions variant virus [DOI] 10.1021/acs.jpcb.2c00708 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Gamma and Delta Variants of Concern Might Undermine Neutralizing Activity Generated in Response to BNT162b2 mRNA Vaccination우려되는 SARS-CoV-2 감마 및 델타 변이체가 BNT162b2 mRNA 백신 접종에 대한 반응으로 생성된 중화 활성을 약화시킬 수 있음Article Published on 2022-04-152022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activity Alpha Alpha variant Anti-spike BNT162b2 BNT162b2 mRNA Complete concern Delta delta variant Delta variants effective evade evaluated Gamma Gender healthcare IgG individual Italian less mRNA neutralized Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody positively correlated provide raised reduction reduction in response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccines SARS-CoV-2 VOCs sera serum serum sample serum samples subject sustained titre vaccination Vaccine variant variants Viral viral isolate viral isolates virus VOCs [DOI] 10.3390/v14040814 PMC 바로가기 [Article Type] Article
Estimating the Neutralizing Effect and Titer Correlation of Semi-Quantitative Anti-SARS-CoV-2 Antibody Immunoassays반정량적 항SARS-CoV-2 항체 면역분석법의 중화 효과 및 역가 상관관계 추정Article Published on 2022-04-142022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Anti-RBD IgG anti-SARS-CoV-2 antibody antibodies antibody Antibody responses antibody tests assays best Chemiluminescent assay comparable convalescent phase correlated correlation COVID-19 cut-off Effect evaluated IgG antibodies IgG antibody immunoassay infections investigated linear linear correlation neutralization test Neutralizing Neutralizing activity neutralizing antibody nucleocapsid protein nucleopcapsid (NP) protein Pearson plaque reduction neutralization Plaque reduction neutralization test PRNT Protein RBD Receptor-binding domain SARS-CoV-2 SARS-COV-2 infection semi-quantitative sensitivity serology specificity spike (S) protein Spike protein sVNT the RBD the receptor-binding domain the spike protein titer total antibodies total antibody virus neutralization test [DOI] 10.3389/fcimb.2022.822599 PMC 바로가기 [Article Type] Article
Identification of Entry Inhibitors against Delta and Omicron Variants of SARS-CoV-2SARS-CoV-2의 Delta 및 Omicron 변이체에 대한 진입 억제제 식별Article Published on 2022-04-062022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approved authentic SARS-CoV-2 virus Beta block Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta Delta variants dolutegravir domain dominant drug drug library EC50 value EC50 values Entry inhibitor entry inhibitors Etravirine identification Infection inhibited inhibitor inhibitors molecular docking molecular interaction neutralization test neutralizing activities Neutralizing activity omicron outbreak plaque reduction neutralization Plaque reduction neutralization test pseudovirus pseudovirus entry pseudoviruses RBD RBD domain receptor Receptor-binding domain residue robust SARS-CoV-2 SARS-CoV-2 virus SARS-CoV2 severe acute respiratory syndrome Coronavirus significantly Spike protein Spike proteins the RBD the receptor-binding domain These data variants Vero E6 Vero E6 cell VERO E6 cells viral entry viral spike protein viral variant was used [DOI] 10.3390/ijms23074050 PMC 바로가기 [Article Type] Article
Decreased and Heterogeneous Neutralizing Antibody Responses Against RBD of SARS-CoV-2 Variants After mRNA VaccinationmRNA 백신 접종 후 SARS-CoV-2 변이체의 RBD에 대한 감소된 이종 중화 항체 반응Article Published on 2022-04-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] accumulate ACE2 acute respiratory syndrome Against Alpha analyzed Antibody neutralization approaches B.1.1.7 B.1.427 B.1.617.1 B.1.617.2 binding BNT162b2 BNT162b2 mRNA Cohort coronavirus coronavirus 2 COVID-19 COVID-19 mRNA vaccine COVID-19 mRNA vaccines Decreased Delta domain dose E484K/Q mutation Epsilon evade FIVE flow cytometry Gamma healthcare worker Healthcare workers healthcare workers (HCW) heterogeneity highest immune protection knowledge L452R magnitude Moderna mRNA mRNA vaccine mRNA vaccines mRNA1273 Mutation naïve individual naïve individuals natural infection Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibodies (NAB) neutralizing antibody neutralizing response P.1 Pfizer-BioNTech provided raise RBD RBD of SARS-CoV-2 RBD variant receiving Receptor binding domain receptor binding domain (RBD) Receptor-binding domain regimen respiratory response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant increase significantly higher specific neutralizing antibodies Spike protein Spread subject subsequent tested the RBD vaccinated individuals vaccination Vaccine vaccine doses Vaccine-induced immunity variant Viral viral spike protein viral variant Viral variants Wuhan strain [DOI] 10.3389/fimmu.2022.816389 PMC 바로가기 [Article Type] Article