Potential effects of icariin, the Epimedium-derived bioactive compound in the treatment of COVID-19: a hypothesisReview Published on 2022-09-012023-07-09 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] COVID19(2023년), [키워드] COVID-19 Cytokine storm Icariin oxidative stress SARS-CoV-2 [DOI] 10.1007/s00210-022-02262-y PMC 바로가기 [Article Type] Review
G6PD deficiency: imbalance of functional dichotomy contributing to the severity of COVID-19G6PD 결핍: COVID-19의 중증도에 기여하는 기능적 이분법의 불균형Review Published on 2022-09-012022-09-11 Journal: Future Microbiology [Category] 유전자 메커니즘, [키워드] adenine affected cause caused contributing to Control COVID-19 COVID-19 patients death Defense defense mechanism deficiency dysregulation enzyme functional G6PD G6PD deficiency Genetic genetic factor highlight Human illnesses Inflammation Inflammatory response Inflammatory responses mechanism NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate oxidative stress oxygen phosphate reactive oxygen species reactive oxygen specy reduced regulated Regulation removal ROS severity severity of COVID-19 Trigger [DOI] 10.2217/fmb-2021-0299 PMC 바로가기 [Article Type] Review
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN SurveyResearch article Published on 2022-09-012022-10-05 Journal: Pharmacological research [Category] 바이오마커, [키워드] Administered ascorbic acid Borg Combination COVID-19 Critical Effect effort Endothelial dysfunction endothelial function Evidence favorable effect IMPROVE in both groups indicate L-Arginine long-COVID oxidative stress pathophysiology Patient receiving recent reduce Result significant difference significantly lower survey Symptom Symptoms Treatment treatment arm two groups typical symptom Vitamin Vitamin C [DOI] 10.1016/j.phrs.2022.106360 [Article Type] Research article
Angiotensin II induces reactive oxygen species, DNA damage, and T cell apoptosis in severe COVID-19Research article Published on 2022-09-012022-10-05 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome Admission age Angiotensin II angiotensin II receptor angiotensin-converting enzyme 2 antioxidant Apoptosis coronavirus coronavirus disease COVID-19 COVID-19 pathogenesis death DNA damage DNA oxidation ELISA flow cytometry form healthy controls high plasma level ICU ICU Patients immunofluorescence induce infected with SARS-CoV-2 Infection intensity intensive care Lymphocyte count Lymphocytes lymphopenia monocyte neighboring cells objective oxidative stress Patient patients patients with COVID-19 PBMC Predictive programmed cell death protease reactive oxygen species reactive oxygen specy receptor released responsible Result ROS ROS production SARS-CoV-2 severe COVID-19 survival T cell T-cell Trigger was measured were measured [DOI] 10.1016/j.jaci.2022.06.020 [Article Type] Research article
Dual effects of supplemental oxygen on pulmonary infection, inflammatory lung injury, and neuromodulation in aging and COVID-19Review article Published on 2022-09-012022-10-05 Journal: Free radical biology & medicine [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] activating Activation acute lung injury acute respiratory distress syndrome (ARDS) age aging Analysis Anti-inflammatory antioxidant ARDS attenuate Biomarkers Blood oxygen saturation Brain cause caused cellular cellular damage Central nervous system Cholinergic anti-inflammatory pathway chronic inflammation clinical Clinical outcome COVID-19 COVID-19 patient COVID-19 patients death decrease Defense distress dysregulated Effect function functions humans hyperinflammation IMPROVE increase in infected with SARS-CoV-2 infections Inflammation inflammatory lung injury Inflammatory response inhibiting Innate immunity likelihood lung lung cells Lung inflammation macrophages master regulator Mitochondria morbidity and mortality oxidative oxidative stress oxygen Oxygen therapy pathway positive correlation positively correlated Postmortem prolonged exposure Pulmonary infection reactive oxygen specy receiving receptor regulate regulated resulting ROS Safe Sepsis shown Signaling supplemental oxygen Supplemental oxygen therapy susceptibility syndrome Therapeutic approach Toxicity treat α7 nicotinic acetylcholine receptor α7nAChR [DOI] 10.1016/j.freeradbiomed.2022.08.004 [Article Type] Review article
Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndromeReview article Published on 2022-09-012022-10-05 Journal: Journal of advanced research [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome affected Aside chronic fatigue syndrome clinical complication cognitive cohorts Complication concept coronavirus Coronavirus-2 COVID-19 COVID-19 infection COVID-19 patient COVID-19 symptom defined described Diagnosis disease dysfunction Dyspnoea Effect exacerbate fatigue headache IL-6 immune Inflammation interleukin-6 longitudinal malaise myalgic encephalomyelitis Necrosis organs orthostatic overlap oxidative stress pandemic pathology Patient Post COVID-19 condition Post-infection pro-inflammatory progression proportion reported required review SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection Sequelae Survivors Symptom syndrome TNFα Trigger viral infection virus WHO World Health Organisation [DOI] 10.1016/j.jare.2021.11.013 [Article Type] Review article
SARS-CoV-2 infects human cardiomyocytes promoted by inflammation and oxidative stressSARS-CoV-2는 염증과 산화 스트레스에 의해 촉진되는 인간 심근세포를 감염시킵니다Article Published on 2022-09-012022-09-12 Journal: International journal of cardiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accounted acute respiratory syndrome analysed antiviral intervention Apoptosis apoptotic cardiac damage Cardiomyocytes cell damage cells change co-morbidities condition conditions COVID-19 patient Cytokine storm Donor driven by heart Heart damage heart failure infect Inflammation Inflammatory involved marker mechanism Myocardial non-infected oxidative stress Patient pro-inflammatory promote promoted protease provide Respiratory illness SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 infected patient target tissue triggered ventricular viral entry virus entry [DOI] 10.1016/j.ijcard.2022.05.055 PMC 바로가기 [Article Type] Article
Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients코로나19 환자에서 다양한 비타민과 미네랄의 분자 기전과 치료 효과Review Published on 2022-09-012022-09-11 Journal: Journal of trace elements in medicine and biology [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제, [키워드] activities addition Anti-inflammatory drugs antioxidant antioxidants Antiviral antiviral properties antiviral property boost component copper correlation COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness cytokine release Cytokines disease Effect Factor Health high mortality immune function immune functions immune system Increased Infectious disease Inflammation Inflammatory cytokine Inflammatory cytokines iron lack manganese mechanism metabolic processe metabolic processes Micronutrient micronutrients mineral Minerals modulate mortality rate mortality rates oxidative stress Prevalence rapidly spreading disease reason remedy respiratory distress SARS-CoV-2 Selenium severe COVID-19 Severe respiratory distress Support therapeutic effect Trace element trace elements Treatment Vitamin vitamin A vitamins Zinc [DOI] 10.1016/j.jtemb.2022.127044 PMC 바로가기 [Article Type] Review
The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implicationsArticle Published on 2022-08-312022-11-15 Journal: Biochemical Journal [Category] 진단, [키워드] activities amyloid microclots antioxidants biochemical burst Capillaries cell activation conditions COVID disease element Evidence explain hyperinflammation hypoxia implication Inflammatory diseases initiated Injury involved ischaemia–reperfusion injury. Long Long COVID malaise marker mechanism mechanisms metabolite Occurrence oxidative stress pathology produced reactive oxygen specy relapsing reperfusion rheumatoid arthritis Safe therapeutic Therapeutic benefit variety [DOI] 10.1042/BCJ20220154 PMC 바로가기
Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral SclerosisRandomized Controlled Trial Published on 2022-08-292022-10-05 Journal: Neurology® neuroimmunology & neuroinflammation [Category] 바이오마커, 임상, [키워드] 1:1 ALS assigned autologous average baseline changed class classification clinical study Combined conducted COVID-19 pandemic Disease progression Dose escalation dose-escalation doses effective elevated enrolled Evidence extension Good group help IL-2 Inflammation injection intervals Lateral Sclerosis LDL Leukapheresis low-density marker matching placebo Open-label oxidative stress oxidized participant Patient Person Placebo Practice progression provide Randomized controlled trial Randomly RCT receive receptor Regulatory reliability Safe slow disease suppressive function T-lymphocyte therapy Treatment Treg Tregs Year [DOI] 10.1212/NXI.0000000000200019 PMC 바로가기 [Article Type] Randomized Controlled Trial