Crisis Brings Innovative Strategies: Collaborative Empathic Teleintervention for Children with Disabilities during the COVID-19 LockdownPerspective Published on 2021-02-112023-06-13 Journal: International Journal of Environmental Research an [Category] MERS, [키워드] abilities Child COVID-19 family-centered functioning pandemic Participation rights Routines-Based Model Teleintervention [DOI] 10.3390/ijerph18041749 PMC 바로가기 [Article Type] Perspective
A longitudinal study on the COVID-19 pandemic and its divergent effects on social participation and mental health across different study groups with and without mental disordersOriginal Paper Published on 2021-02-102022-10-28 Journal: Social psychiatry and psychiatric epidemiology [Category] COVID-19, MERS, SARS, [키워드] assessment BSI-18 changes in chronic coronavirus COVID-19 COVID-19 pandemic detrimental effect disorder Effect effort Germany impairment IMPROVE Inclusion index initial inventory investigated lockdown lockdown restriction lockdown restrictions measure Mental Mental disorder mental health pandemic participant Participation physical distancing Psychological well-being Resilience Result Social participation spread of COVID-19 study group supplementary material were assessed [DOI] 10.1007/s00127-021-02025-9 PMC 바로가기 [Article Type] Original Paper
A Phase I/II Clinical Trial to evaluate the efficacy of baricitinib to prevent respiratory insufficiency progression in onco-hematological patients affected with COVID19: A structured summary of a study protocol for a randomised controlled trialCOVID19에 감염된 종양-혈액학적 환자에서 호흡 부전 진행을 예방하기 위한 바리시티닙의 효능을 평가하기 위한 I/II상 임상 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-02-052022-09-10 Journal: Trials [Category] MERS, 임상, 치료제, [키워드] 1:1 AAK1 absence activator Acute respiratory failure Administered administration Adverse adverse events affected alkaline phosphatase All participants allergy Alpha alpha error angina pectoris Antibiotics appearance ARDS Arm assigned AST/ALT Baricitinib baseline beta error Bilirubin Blinding Blood Breastfeeding can be used candidate Candidates capture Cardiac arrhythmia carried change clearance clinical clinical condition clinical suspicion clinical trials Coagulation Cohort Common Terminology Criteria Comorbidity Complete completion Compliance congestive heart failure control arm Controlled trial corticoid Corticosteroids COVID19 creatinine creatinine clearance CRP D-dimer Day Deep venous thrombosis description Deterioration Dexamethasone dimer discharge discretion disease dissemination diverticulitis dose dropout rate Duration of therapy ECMO Efficacy electronic case report form element eligibility criteria Enrollment evaluate exclusion criteria expected experimental arm extracorporeal membrane oxygenation febrile neutropenia ferritin followed by form fraction Gas exchange greater HBV HCV hemodynamic instability High-flow nasal cannula HIV HIV infection ICU immobilization immunological impossibility incidence include indication Infection infection with SARS-CoV-2 Inflammatory response interfere interferon Interim interim analysis interleukin interleukin 6 interstitial pneumonia Intervention intestinal perforation Invasive mechanical ventilation investigational agent investigator jak inhibitors Jak-STAT Laboratory laboratory parameter Laboratory parameters LDH less limit limits management mechanical ventilation medical history Medicine meet Methylprednisolone Mild ARDS Mortality multi organ failure nasal nasal cannula need for oxygen neutropenia neutrophil Neutrophils Non-invasive number objective on mechanical ventilation oncological patients onset of symptom open open label oral medication organ dysfunction Organ failure outcome oxygen oxygen support PaFi participant Participants Participation pathogen Pathogens pathway Patient patients performance status performed phase Phase 1 Phase 2 Phase I phosphatase platform Pneumonia poor prognosis positive Prednisone pregnancy test pregnant prejudice Prevent progression Prophylaxis Protein protein kinase protocol Psychiatric psychiatric illness Pulmonary embolism radiological randomisation randomised randomised controlled trial randomization Randomized Randomized controlled trial receive receptor recruitment REDCap REDcap platform reduce reduced Remdesivir removal report reported required respiratory Respiratory failure Respiratory function respiratory insufficiency respiratory tract Sample size SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection Secondary objectives Sepsis severe adverse event severe adverse events severe pneumonia severe respiratory failure Spain Spanish Standard of care STAT status study enrollment Study protocol supplemental oxygen requirement supplemental oxygen requirements supplementary material Support surgical surgical intervention Symptom symptomatic Tablet Therapies therapy thromboembolic disease thrombosis Tocilizumab total bilirubin Toxicity Transcription transducer Treatment treatment period Trial unstable angina use of corticosteroid Venous thrombosis Version viral endocytosis website Withdrawal worsening [DOI] 10.1186/s13063-021-05072-4 PMC 바로가기 [Article Type] Letter
Early use of corticosteroids in non-critical patients with COVID-19 pneumonia (PREDCOVID): a structured summary of a study protocol for a randomised controlled trialCOVID-19 폐렴(PREDCOVID)이 있는 중요하지 않은 환자에서 코르티코스테로이드의 조기 사용: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-01-262022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 48 hours adverse event allocation approved ARMS attending physician authors Blinding Care Caregiver Caregivers Child chronic Chronic kidney disease Chronic respiratory failure Composite computer consent form Control Corticosteroids COVID-19 COVID-19 pneumonia cumulative incidence Date Day decrease defined delirium Deterioration dissemination early treatment Efficacy element emergency room evaluate exclusion criteria FiO2 glycemic GRADE grade 3 hospital ICU inclusion criteria Infection infections insulin intensive care interruption Intervention invasive Invasive mechanical ventilation investigator Kidney disease Liver damage Mechanical mechanical ventilation minute nasal nasal cannula not blinded number objective on mechanical ventilation outcome oxygen Oxygen requirements participant Participation Patient patients patients with COVID-19 PCR Pneumonia Pragmatic pragmatic clinical trial Prednisone Pregnancy Primary outcome principal investigator progression protocol random randomised randomised controlled trial Randomized registration number Requirement respiratory Respiratory failure responsibility RT-PCR Sample size secondary Serious Adverse Event Serious Adverse Events Stata statistician status steroid Study protocol submitted supplementary material time Treatment Trial Trial registration urinary tract infection use of corticosteroid usual care venturi mask was used website with COVID-19 [DOI] 10.1186/s13063-021-05046-6 PMC 바로가기 [Article Type] Letter
Participation in Fraternity and Sorority Activities and the Spread of COVID-19 Among Residential University Communities — Arkansas, August 21–September 5, 2020Full Report Published on 2021-01-082022-10-30 Journal: Morbidity and Mortality Weekly Report [Category] COVID-19, MERS, [키워드] activity COVID-19 Fraternity Participation university [DOI] 10.15585/mmwr.mm7001a5 PMC 바로가기 [Article Type] Full Report
Psychological impact of COVID‐19 pandemic on healthcare workers in China Xi’an central hospitalOriginal Research Published on 2021-01-062022-10-28 Journal: Brain and Behavior [Category] COVID-19, [키워드] addition affected analyzed automatically center China clinician collected counseling COVID‐19 COVID‐19 emotional exhibited Factor globe healthcare worker Healthcare workers hospital Intervention investigated mental health Nurse objective pandemic participant Participation provided Psychological psychological Impact questionnaire Responder response responsibility Result significantly statistically status Stress Support the epidemic work [DOI] 10.1002/brb3.2028 PMC 바로가기 [Article Type] Original Research
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection경도 높은 처리량 TCR 레퍼토리 프로파일링은 가벼운 COVID-19 감염 후 T 세포 기억 형성의 역학을 보여줍니다Short Report Published on 2021-01-052022-09-10 Journal: eLife [Category] 치료기술, [키워드] adaptive antibodies antiviral immune response caused CD4 CD8 changes in characteristic clonal expansion clone coronavirus COVID-19 COVID-19 infection COVID-19 patients cross-reactive cross-reactivity dataset Diversity donors fraction global pandemic Human immune memory immune response infected cell infected cells Infection killing longitudinal majority memory memory formation memory T memory T cell memory T cells Mild mild case motif Occurrence Participation Phenotypes RepSeq resulting reveal SARS-CoV-2 SARS-CoV-2 coronavirus Sequencing T cell T cells T-cell T-cell receptor T-cell Response TCR TCR sequence TCR sequences the SARS-CoV-2 virus-specific antibodies [DOI] 10.7554/eLife.63502 PMC 바로가기 [Article Type] Short Report
Recombinant human C1 esterase inhibitor (conestat alfa) in the prevention of severe SARS-CoV-2 infection in hospitalized patients with COVID-19: A structured summary of a study protocol for a randomized, parallel-group, open-label, multi-center pilot trial (PROTECT-COVID-19)입원한 COVID-19 환자의 중증 SARS-CoV-2 감염 예방을 위한 재조합 인간 C1 에스테라제 억제제(conestat alfa): 무작위, 병렬 그룹, 공개 라벨, 다중 센터에 대한 연구 프로토콜의 구조화된 요약 파일럿 시험(PROTECT-COVID-19)Letter Published on 2021-01-042022-09-10 Journal: Trials [Category] 임상, [키워드] 24 hour 24 hours Activation activities acute lung injury addition adjusted Administered administration allergy Antibiotics anticipated anticoagulation arterial Arterial hypertension Basel Blinding BMI Brazil Breast Breast feeding breathing ambient air C-reactive protein C1 esterase inhibitor cardiovascular disease Caregivers changes in Chest Child-Pugh score chronic chronic pulmonary disease chronic renal disease cirrhosis class clinical Clinical improvement clinical trial comparator comparator Patients complement complement system completion conducted Conestat alfa Contact contact activation system contraindication control group Corticosteroids COVID-19 COVID-19 patient CT scan death defined discharge disease disease severity dissemination drug Duration Efficacy and safety element eligibility enrolment evidence of experimental arm family members FIVE followed by history hospital Hospitalization hospitalized patient hypertension ICU IL-6 inhibitor IL-6R improvement Incapacity include inclusion criteria individual Infection inflammatory cascade inflammatory cascades inflammatory proteins inhibitor Interactive Web Response System interim analysis Intravenous injection invasive invasive or non-invasive ventilation investigator-initiated investigators kallikrein kinin system laboratory parameter Liver cirrhosis Local Lung injury mechanical ventilation non-invasive ventilation not blinded number obesity objective Open-label open-label trial Ordinal Scale outcome outcome assessor outcome assessors oxygen oxygen saturation pandemic PaO parallel-group participant Participants Participation Patient performed Pregnancy primary endpoint progression proportion protocol pulmonary disease pulmonary involvement randomised randomization Randomized randomized trial receive recombinant recruited recruitment Registered Remdesivir renal renal disease required risk factor Sample size SARS-COV-2 infection SARS-CoV-2 pandemic scale screened secondary Secondary outcomes severe COVID-19 severe SARS-CoV-2 Standard of care status Study protocol subject supplemental oxygen supplementary material suspicion Switzerland Symptom the SARS-CoV-2 the WHO their family members Tocilizumab Treatment treatment arm Trial Two interim analyses Two interim analysis virological clearance website WHO WHO ordinal scale with COVID-19 X-ray [DOI] 10.1186/s13063-020-04976-x PMC 바로가기 [Article Type] Letter
Death Cafés for prevention of burnout in intensive care unit employees: study protocol for a randomized controlled trial (STOPTHEBURN)중환자실 직원의 번아웃 예방을 위한 데스 카페: 무작위 대조 시험(STOPTHEBURN)을 위한 연구 프로토콜Study Protocol Published on 2020-12-112022-08-13 Journal: Trials [Category] MERS, SARS, 임상, [키워드] Administered administration analyzed Anxiety Anxiety Disorder Behavioral symptoms Burnout clinician Clinicians collaboration collected Community conducted control arm COVID-19 Critical care Critically ill Critically ill patient critically ill patients death Death Café Depression effective Enrollment equivalent event events facilitated GAD-7 Generalized Generalized Anxiety Disorder group health problems Healthcare workers hospital ICU include intensive care intensive care unit Intervention inventory leads mental health problems mitigate Moral distress Nurses Occupational stress offer outcome participant Participation patient mortality patient safety physician Prevent Primary outcome provide psychotherapist Qualitative Questionnaires Randomized Randomized controlled trial recruited reduce Reflection score secondary Secondary outcomes social interaction Study protocol subject susceptible syndrome Teledebriefing trauma Trial registration Virtual debriefing vulnerable population Work place retention [DOI] 10.1186/s13063-020-04929-4 PMC 바로가기 [Article Type] Study Protocol
Uncertainty, error and informed consent to challenge trials of COVID-19 vaccines: response to Steel et al불확실성, 오류 및 COVID-19 백신 시도에 대한 정보에 입각한 동의: Steel et al에 대한 대응Comment Published on 2020-12-012022-09-11 Journal: Journal of medical ethics [Category] SARS, 임상, [키워드] Autonomy clinical trials condition COVID-19 COVID-19 vaccine COVID-19 vaccines Effect Eyal form human infection ignorance Informed consent knowledge likelihood participant Participation question Research Research Ethics steel Trial trials Uncertainty [DOI] 10.1136/medethics-2020-106793 PMC 바로가기 [Article Type] Comment