Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patientsInflammasomes는 SARS-CoV-2 감염에 반응하여 활성화되며 환자의 COVID-19 중증도와 관련이 있습니다.Article Published on 2021-03-012022-09-12 Journal: The Journal of Experimental Medicine [Category] SARS, 진단, [키워드] activated Activation Autopsy caspase-1 characterized cleavage Clinical outcome correlated COVID-19 COVID-19 patients COVID-19 severity disease severity IL-18 IL-1β IL-6 Inflammasome inflammasome activation Inflammation Inflammatory inflammatory process LDH marker moderate molecular NLRP3 inflammasome Organ failure outcome pathophysiology Patient patient death PBMC platform potential therapeutic target promote SARS-COV-2 infection sera severe COVID-19 patients severity the disease tissue with COVID-19 [DOI] 10.1084/jem.20201707 PMC 바로가기 [Article Type] Article
Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses최첨단: 마우스 SARS-CoV-2 에피토프, 감염 및 백신 유발 CD8 T 세포 반응 밝혀내Article Published on 2021-03-012022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] SARS, 변종, 치료법, [키워드] Adenovirus CD8 CD8 T cell COVID-19 COVID-19 vaccine cross-reactivity Culture Cutting dominant elicited epitope Heterologous HLA-A HLA-A*02 hospitalized patient hospitalized patients human ACE2 human disease Humoral immunity Immunity immunization intranasal magnitude memory mice mouse mucosa PBMC peptide recombinant adenovirus respiratory mucosa response responses robust SARS-CoV-2 SARS-CoV-2 nucleoprotein severity Spike protein systemically T cell T cell response T cell responses transgenic mice vaccination vaccine-elicited T cell vector viral spike protein Viral variants [DOI] 10.4049/jimmunol.2001400 PMC 바로가기 [Article Type] Article
Impact of SARS-CoV-2 infection on the recovery of peripheral blood mononuclear cells by density gradient밀도 구배에 의한 말초 혈액 단핵 세포의 회복에 대한 SARS-CoV-2 감염의 영향Article Published on 2021-03-012022-09-01 Journal: Scientific Reports [Category] SARS, 진단, [키워드] alteration Biological techniques Blood blood donor Cell centrifugation changes in circulating Complication coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients density gradient density gradient centrifugation disease severity Donor early phase early stage exhibited explain forms fraction healthy control Hyperinflammatory Hyperinflammatory response immature Immune-mediated Impact IQR lymphocyte Lymphocytes median Medical research medium Monocytes mononuclear cell mononuclear cells neutrophil Neutrophils Patient PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells Predictive reduced respiratory responsible Result SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus infection sedimentation severity shift Spread subset t -test the cell the cells the disease virus infection while Whole blood [DOI] 10.1038/s41598-021-83950-2 PMC 바로가기 [Article Type] Article
Inflammation and Antiviral Immune Response Associated With Severe Progression of COVID-19COVID-19의 심각한 진행과 관련된 염증 및 항바이러스 면역 반응Clinical Trial Published on 2021-02-182022-08-13 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, 신종인플루엔자, 유전자 메커니즘, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 severity Disease progression disease severity downregulation Ex vivo Functional enrichment analysis H1N1 H1N1 virus healthy controls hemagglutinin host immune system hypercytokinemia IFNs immune cells immune response immune signature impair impaired function include indicate indicated Infection Inflammation Inflammatory Inflammatory response Influenza influenza A interferons LAG3 microarray analysis mild COVID-19 patient MMP9 mononuclear cell mononuclear cells myeloid cell myeloid cells Neutrophils novel respiratory disease overactivation overactive patients patients with influenza PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells potential mechanism potential mechanisms progression promote proportion Protein regulate Regulation respiratory Respiratory disease respond response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe and mild COVID-19 patients severe COVID-19 severe SARS severe SARS-CoV-2 severity Signaling SKAP1 spike Spike protein Stimulation suggested T cell T cells T cells TLR6 Transcriptome Type I IFN type I IFNs type I interferon type I interferons unique upregulation whole genome transcriptome with COVID-19 [DOI] 10.3389/fimmu.2021.631226 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 early infection signature identified potential key infection mechanisms and drug targetsSARS-CoV-2 조기 감염 시그니처는 잠재적인 주요 감염 메커니즘 및 약물 표적 식별Research Article Published on 2021-02-182022-09-10 Journal: BMC Genomics [Category] MERS, 신약개발, 유전자 메커니즘, [키워드] addition antidepressants association atorvastatin BALF BALF cells bimodal biopsies Bronchoalveolar lavage fluid Bronchoalveolar lavage fluid cells candidate Candidates caused Cell characterized COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 outbreak COVID-19 treatments cultured cell cultured cells database dataset deaths Differential gene expression disease drug drug target early infection effective Efficacy expression profile Gene Expression gene signature HDAC healthy healthy and infected patients highlighting ibuprofen identify IFIT2 Immune cell immune cells infected patient infected with SARS-CoV-2 Infection infection mechanism inhibitors investigated ketoconazole lung lung biopsies mechanism moderate mononuclear cell mononuclear cells Mortality NFKBIA PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells PPP1R15A Previous studies previous study public health Result robust safety profile SARS-CoV-2 SARS-CoV-2 gene expression signature SARS-COV-2 infection Sequencing severely infected patient severely infected patients severity shown signature single-cell supplementary material the disease the SARS-CoV-2 therapy TNFAIP3 transcriptional activity treating SARS-CoV-2 infection Treatment Vaccine [DOI] 10.1186/s12864-021-07433-4 PMC 바로가기 [Article Type] Research Article
Human Dental Pulp Stem Cells Modulate Cytokine Production in vitro by Peripheral Blood Mononuclear Cells From Coronavirus Disease 2019 PatientsCell and Developmental Biology Published on 2021-02-052022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] activated acute respiratory syndrome co-culture Concentration conditions Contact coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine dental dental pulp stem cells deregulated DPSC DPSCs form GM-CSF granulocyte healthy subject Human hyper-inflammation IFNγ IL-10 IL-12 IL-13 IL-17A IL-18 IL-1β IL-2 IL-21 IL-22 IL-23 IL-27 IL-4 IL-5 IL-6 IL-9 immune response immunomodulation in vitro interleukin investigated Macrophage mechanism mesenchymal stem cell Mesenchymal stem cells modulate modulation mononuclear cell MSC MSCs Multi-organ damage not affected Patient PBMC PBMCs peripheral Peripheral blood Pneumonia Production promote Pulp Real-time PCR Result SARS-CoV-2 STEM stem cell subset supernatant tissue regeneration TNFα [DOI] 10.3389/fcell.2020.609204 PMC 바로가기 [Article Type] Cell and Developmental Biology
Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis바이러스-숙주 상호작용 및 단백질체 조사, SARS-CoV-2 발병에 영향을 미치는 잠재적인 독성 요인 밝혀Article Published on 2021-01-152022-09-11 Journal: Med (New York, N.Y.) [Category] SARS, 유전자 메커니즘, [키워드] Academy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral therapy Appointment Blood coagulation CAS caused cellular challenge chemotaxis China Chinese clinical Coagulation Commission contribute coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patients cytokine Cytokine storms development downregulation effective facilitate Factor foundation global public health Host host inflammatory response host protein host proteins IL-8 Infrastructure Innovative Research institution interact interactome interleukin interleukin-8 lack learning maintenance Major mechanism molecular mechanism mononuclear cell natural neutrophil neutrophil activation Neutrophils NF-κB NKRF non-structural protein nsp10 pandemic PBMC PBMCs Peripheral blood Potential Professor Program Protein proteome proteomics pursuit representing research and development resource respiratory reveal SARS-CoV-2 SARS-CoV-2 pathogenesis Scholar Science Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 Shanghai Signaling significantly SII survey T cell T cell receptor target team technology therapeutic interventions Transmission Trigger triggers university upregulation was used [DOI] 10.1016/j.medj.2020.07.002 PMC 바로가기 [Article Type] Article
Single-Cell RNA Sequencing of Tocilizumab-Treated Peripheral Blood Mononuclear Cells as an in vitro Model of InflammationGenetics Published on 2021-01-052022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] antibody bioinformatics and computational biology biologic Cell clinical trial COVID-19 Cytokine storm Effect expression Health Hypothesis IL-6 IL-6 receptor in vitro Inflammation inhibit kidney transplant recipient Kidney transplantation Model Monocytes Multiple Pathways PBMC performed peripheral reduced regulatory cytokine rejection RNA single cell RNA seq single-cell level Single-cell RNA sequencing stimulated Support the cytokine storm tocilizumab (IL-6 inhibitor) transcriptomics Treatment Trial [DOI] 10.3389/fgene.2020.610682 PMC 바로가기 [Article Type] Genetics
High Induction of IL-6 Secretion From hUCMSCs Optimize the Potential of hUCMSCs and TCZ as Therapy for COVID-19-Related ARDShUCMSC에서 IL-6 분비의 높은 유도는 COVID-19 관련 ARDS에 대한 치료법으로서 hUCMSC 및 TCZ의 잠재력을 최적화합니다Article Published on 2021-01-012022-09-12 Journal: Cell transplantation [Category] 진단, [키워드] acute respiratory distress analyzed anti-inflammatory effect ARDS Biological Blood Cell cellular Concentration correlation COVID-19 cytokine secretion ELISA evaluated Exogenous expression functional hUCMSC Hyperinflammatory syndrome IL-6 IL-6 level IL-6 levels IL-6 neutralizing antibody IL-6 receptor IL-6R induction Inflammation inhibited inhibitory effect interleukin-6 less Microarray mononuclear cell mRNA expression MTT Neutralizing neutralizing antibody PBMC PBMCs peripheral Potential proliferation reached reported Respiratory failure Responder Severe COVID-19 pneumonia supernatant syndrome TCZ therapeutic potential therapy Tocilizumab treat umbilical was measured was used [DOI] 10.1177/09636897211054481 PMC 바로가기 [Article Type] Article
Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19과염증 COVID-19에서 백혈구에 의한 순환 사이토카인과 자발적 사이토카인 생산 간의 불일치Clinical Trial Published on 2021-01-012022-09-12 Journal: Journal of leukocyte biology [Category] MERS, 임상, 진단, [키워드] activated Activation analyzed blockade cellular circulating cytokine circulating leukocyte contribute Control controls COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine production Cytokine storm cytokine storm, monocytes. Cytokines disease example flow cytometry healthy control healthy controls hyperinflammation Hyperinflammatory IL-1β IL-6 IL-8 immunoassay investigated leukocyte LPS lymphocyte mismatch monocyte Monocytes Patient patients with COVID-19 PBMC produced recruited Sepsis sepsis patient sepsis patients severe COVID-19 Support surface marker TNF Treatment university was used were measured worldwide pandemic [DOI] 10.1002/JLB.5COVBCR0720-310RR PMC 바로가기 [Article Type] Clinical Trial