Comparison of Moderna versus Pfizer-BioNTech COVID-19 vaccine outcomes: A target trial emulation study in the U.S. Veterans Affairs healthcare systemResearch article Published on 2022-03-052022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 95% CI adjusted hazard ratio Affair age all age groups analyzed BNT162b2 category clinical trials Comorbidity COVID-19 vaccination COVID-19 vaccine death delta variant Department Electronic health records finding follow-up period follow-up time funding greater Healthcare system Hospitalization Infection less Medicare Moderna mRNA COVID-19 vaccine mRNA-1273 National occurred outcome Pfizer-BioNTech predominant propensity score matching rates of infection recipient recipients risk risk of infection SARS-COV-2 infection SARS-CoV-2 infections shown significantly lower statistically significant the vaccine Trial vaccination Vaccine vaccine dose vaccine group veteran [DOI] 10.1016/j.eclinm.2022.101326 [Article Type] Research article
Estimation of Serial Interval and Reproduction Number to Quantify the Transmissibility of SARS-CoV-2 Omicron Variant in South Korea한국에서 SARS-CoV-2 오미크론 변이체의 전염성을 정량화하기 위한 일련 간격 및 복제 수 추정Article Published on 2022-03-042022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed B.1.1.529 children Community coronavirus CrI distribution estimate estimation interval likelihood Local maximum likelihood estimation number omicron Omicron variant outbreak predominant public health measures reconstructed reduce reproduction Reproduction number risk SARS-CoV-2 Serial interval severe acute respiratory syndrome Coronavirus significantly shorter South Korea Standard deviation the mean Transmissibility Transmission variant [DOI] 10.3390/v14030533 PMC 바로가기 [Article Type] Article
Clinicopathologic characteristics of severe COVID-19 patients in Mexico City: A post-mortem analysis using a minimally invasive autopsy approachResearch Article Published on 2022-03-032022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] alteration Analysis approach Autopsies Autopsy Characteristics characterized Clinical finding cohort study cohorts correlation COVID-19 Deceased demonstrated described diagnosis of SARS-CoV-2 diagnostic Diffuse alveolar damage Endothelitis feature hallmark hepatic histologic histological histology Histopathology Inflammation Injury Interstitial nephritis invasive kidney Liver function Liver histology liver tissue lung Lung compliance mechanical ventilation Mexico City Necrosis neutrophilic objective Patient performed Pneumonia Post-mortem predominant reported Result SARS-CoV-2 positivity setting severe COVID-19 patient severe SARS-CoV-2 steatosis the disease thrombosis [DOI] 10.1371/journal.pone.0262783 PMC 바로가기 [Article Type] Research Article
Assessment of Clinical Effectiveness of BNT162b2 COVID-19 Vaccine in US Adolescents미국 청소년에 대한 BNT162b2 COVID-19 백신의 임상 효과 평가Research Published on 2022-03-032022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 변종, [키워드] 95% CI Adolescent age assessment association asymptomatic infection B.1.617.2 black BNT162b2 BNT162b2 vaccine case-control study caused Chain Reaction clinical Clinical data Clinical symptoms clinical trial conducted Connecticut Control COVID-19 COVID-19 vaccine defined Delta delta variant dose doses effective Effectiveness elapsed estimate exposure female Final finding General population Hispanic Hospitalization hospitalizations immunization immunized Importance Increases increases in Infection IQR logistic regression models matched control measure median age median time medical record medical records negative test New objective Odds ratio of BNT162b2 participant Participants Point positive test result predominant Primary outcome receiving Relevance residence Result retrospective RT-PCR RT-PCR test SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 positivity SARS-CoV-2 test secondary setting single dose symptomatic and asymptomatic symptomatic infection symptomatic infections test result test results tested the SARS-CoV-2 the vaccine Vaccine vaccine dose vaccine doses variant of SARS-CoV-2 white [DOI] 10.1001/jamanetworkopen.2022.0935 PMC 바로가기 [Article Type] Research
Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants인간 ACE2의 미스센스 변이체는 코로나19에서 ACE2 매개 유전적 위험에 대한 메커니즘을 제공하는 SARS-CoV-2 스파이크에 대한 결합에 강한 영향을 미칩니다. 인터페이스 변이체의 친화도 예측 사례 연구Article Published on 2022-03-022022-09-11 Journal: PLoS Computational Biology [Category] 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 variant ACE2 variants Affect affinity African allele angiotensin bind binding calculated calibration Cell cell types Cohort cohorts distribution ENhance European experiment genetic risk gnomAD greater human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Infection inhibited Interaction Kinetics mechanism missense variant parameter predicted predominant Prevalence PROTECT pseudotype receptor Receptor binding domain reduce reduced SARS-CoV-2 SARS-CoV-2 spike selected spike Spike receptor binding domain SPR strength surface plasmon surface plasmon resonance the Spike this system tissue tissues utility variant variants virulence ΔΔG [DOI] 10.1371/journal.pcbi.1009922 PMC 바로가기 [Article Type] Article
Intrauterine Fetal Demise in the Third Trimester of Pregnancy Associated With Mild Infection With the SARS-CoV-2 Delta Variant Without Protection From Vaccination예방 접종을 받지 않은 SARS-CoV-2 Delta 변이체의 경증 감염과 관련된 임신 3분기의 자궁 내 태아 사망Article Published on 2022-03-022022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Adults coronavirus COVID-19 Delta delta variant demise elevated fetal histology Infection infection rate intrauterine fetal demise Mild symptom mild symptoms morbidity and mortality Placenta placental predominant Pregnancy pregnant women Proinflammatory response protection reduce risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 the SARS-CoV-2 Transmissibility trimester women [DOI] 10.1093/infdis/jiac007 PMC 바로가기 [Article Type] Article
Effective degradation of COVID-19 related drugs by biochar-supported red mud catalyst activated persulfate process: Mechanism and pathwayResearch article Published on 2022-03-012022-10-05 Journal: Journal of Cleaner Production [Category] 치료제, [키워드] activated ARB Arbidol Biochar caused Chloroquine phosphate condition conditions COVID-19 COVID-19 pandemic COVID-19 related drugs Degradation degrade demonstrated drug drugs Effect effective experiments Fourier transform functional group hydroxychloroquine sulfate hydroxyl group indicated investigated pathway Persulfate predominant Red mud residue responsible Spread [DOI] 10.1016/j.jclepro.2022.130753 [Article Type] Research article
Bacterial microbiota in upper respiratory tract of COVID-19 and influenza patientsCOVID-19 및 인플루엔자 환자의 상기도 내 세균성 미생물총Observational Study Published on 2022-03-012022-09-11 Journal: Experimental Biology and Medicine [Category] 유전자 메커니즘, 임상, [키워드] 16S rDNA alteration Bacteria Bacterial Bacterial infections Bacterial microbiota Community COVID-19 COVID-19 group COVID-19 patient COVID-19 patients disease severities Enterobacteriaceae Fusobacterium group groups High-throughput sequencing Influenza knowledge mechanism Microbial communities microbial community microbiota MiSeq mucosal surface not significantly different Pathogens Patient patients patients with influenza platform predominant Prevotella profile provide Pseudomona Pseudomonas rDNA Respiratory disease respiratory viral infection respiratory viral infections Secondary bacterial infections Secondary infection secondary infections Sequencing significantly significantly lower Staphylococcus Streptococcus susceptibility upper respiratory upper respiratory tract viral infections viral infectious diseases [DOI] 10.1177/15353702211057473 PMC 바로가기 [Article Type] Observational Study
Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India인도 차티스가르(Chhattisgarh)에서 발생한 COVID-19 대유행의 2차 물결에서 SARS-CoV-2 혈통 B.1.617.2의 델타 변이형의 원인 역할을 밝히는 게놈 특성 분석Article Published on 2022-03-012022-09-11 Journal: Microbial pathogenesis [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 receptor Alpha Alpha variant Antibody Response B.1 B.1.1.7 B.1.617.1 B.1.617.2 catastrophic categories Chhattisgarh cleaving co-occurrence COVID-19 COVID-19 pandemic D614G D950N dead dead patient Deceased Deletion Delta delta variant ENhance Evolution FIVE furin furin site G142D genomic genomic data HCW healthcare worker help India Intensive L452R Lineage Lineage B.1.1.7 Mild nine outbreak P681R pandemic Patient patients predominant Replication required S1/S2 SARS-CoV-2 SARS-CoV-2 variant second second wave Sequencing spike mutation Surveillance T19R T478K the SARS-CoV-2 Transmissibility Vaccine variant VoC was performed were infected whole-genome sequencing [DOI] 10.1016/j.micpath.2022.105404 PMC 바로가기 [Article Type] Article
Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 20212020년 2월부터 2021년 3월까지 말레이시아에서 지배적인 SARS-CoV-2 계통의 변화로 인해 연속적인 COVID-19 파동이 발생했습니다.Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] A701V Alpha analyzed anti-SARS-CoV-2 B.1.1.7 B.1.351 B.6 Beta Changing China circulating collected coronavirus disease Coronavirus disease 2019 COVID-19 Critical D614G Direct driven by First wave genomic imported cases Increased Lineage lineages Malaysia Molecular epidemiology Phylogenetic Phylogenetic analysis population immunity predominant SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 sequence SARS-CoV-2 seroprevalence second wave Sequencing Seroprevalence serum sample spike mutation spike mutations super-spreading event super-spreading events Surveillance susceptible tested total antibodies variants of concern virus viruses whole genome Whole genome sequencing whole-genome [DOI] 10.1002/jmv.27441 PMC 바로가기 [Article Type] Article