Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein키메라 스파이크 단백질을 발현하는 VSV 벡터에 의해 유발되는 SARS-CoV-2에 대한 보호 면역 강화Article Published on 2021-11-102022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 administration Antigen cellular receptor Chimera chimeric coronavirus COVID-19 vaccines cross-neutralizing cross-reactivity dose elicit elicited enhanced expressing Genetic glycoprotein hACE2 Human human ACE2 humoral immune response immunization immunized immunized mice indicate intramuscular intranasal lesion Lungs macaque macaques mice Mouse models NAb nAb response NAbs neutralizing antibody protective immunity RBD receiving Receptor binding domain replacing rVSV-SARS-CoV-2 S protein Safe SARS-CoV SARS-CoV S SARS-CoV-2 SARS-CoV-2 RBD sera serum significantly significantly increased similarity single dose spike Spike protein spikes the S protein the SARS-CoV-2 titers transplantation Vaccines viruses VSV wild-type [DOI] 10.1038/s41392-021-00797-9 PMC 바로가기 [Article Type] Article
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants면역 탈출 변이의 원천으로서 면역 억제된 COVID-19 환자에서 SARS-CoV-2의 숙주 내 진화Case Reports Published on 2021-11-042022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] Alpha Antibody neutralization Antisera Applying B.1.1.7 B.1.351 Beta Brazil case study COVID-19 COVID-19 patient elicit Evolution Evolution of SARS-CoV-2 exhibiting Genome identify immune Immune escape Immunocompromised Immunocompromised patient Immunocompromised patients Immunosuppressed Immunosuppressive treatment Infection kidney transplant mice Mutation neutralization neutralization titer Neutralizing antibodies neutralizing antibody Next-generation sequencing NGS parental Patient persistent infections protective immunity Re-infection reduced resolved respiratory respiratory specimens RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing South Africa specific neutralizing antibodies susceptible the patient variant variants variants of concern Viral viral genome viral infection virus [DOI] 10.1038/s41467-021-26602-3 PMC 바로가기 [Article Type] Case Reports
Symptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection of a Healthcare Worker in a Belgian Nosocomial Outbreak Despite Primary Neutralizing Antibody Response증상이 있는 중증 급성 호흡기 증후군 코로나바이러스 2 벨기에 병원 발병에서 1차 중화 항체 반응에도 불구하고 의료 종사자의 재감염Comment Published on 2021-11-022022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 characterized clades Cluster Clusters Contact tracing coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 detect effective Evidence evidence of first episode healthcare healthcare worker humoral humoral immune response Humoral immunity IgG immune response Immunoglobulin immunoglobulin A Immunoglobulin G immunoglobulin M Inconclusive individual individuals Infection Most patients Nasopharyngeal swab nasopharyngeal swabs Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses nosocomial occur occurred outbreak Patient persistent infection potential transmission Primary infection protective immunity quantified Reinfection remained respiratory response SARS-CoV-2 Sequencing serum serum IgG severe acute respiratory syndrome Coronavirus Swab swabs symptomatic Transmission Viral viral culture viral genome viral genomes virus replication was measured was performed whole genome Whole genome sequencing worker [DOI] 10.1093/cid/ciaa1850 PMC 바로가기 [Article Type] Comment
Reinfection With Severe Acute Respiratory Syndrome Coronavirus 2: What Goes Around May Come Back AroundArticle Published on 2021-11-012023-06-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, [키워드] protective immunity Reinfection SARS-CoV-2 [DOI] 10.1093/cid/ciaa1541 PMC 바로가기
A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responsesArticle Published on 2021-10-272022-10-04 Journal: Nature Communications [Category] SARS, 변종, [키워드] Administered animal model Antigen Brazil counteract COVID-19 pandemic COVID-19 vaccine effective expressing hamsters Immunity Inactivated vaccine Inactivated Vaccines induce Influenza virus intramuscular vaccination intramuscularly intranasally limit Live attenuated vaccines mice newcastle disease virus produced protective antibody responses protective immune response protective immunity Rapid reduce Replication SARS-CoV-2 SARS-COV-2 infection Spike protein Spread tested Vaccine vaccine candidate variant variants of concern [DOI] 10.1038/s41467-021-26499-y PMC 바로가기 [Article Type] Article
An Assessment of Serological Assays for SARS-CoV-2 as Surrogates for Authentic Virus Neutralization진정한 바이러스 중화를 위한 대리인으로서 SARS-CoV-2에 대한 혈청학적 분석 평가Research Article Published on 2021-10-272022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alkaline phosphatase assessment authentic SARS-CoV-2 virus best biosafety level Biosafety Level 3 Blood BSL3 caused characterized Concordance conditions coronavirus correlation COVID-19 pandemic Critical deaths disadvantage Disadvantages ELISAs embryonic enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays fluorescent followed by future infection global pandemic gold green fluorescent protein identify immunoassays increasingly Infection level 3 luciferase neutralization Neutralization assay neutralization assays Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses Neutralizing assay outbreak performed phosphatase presence of antibody Protective protective antibodies Protective antibody protective immunity Protein pseudotyped Pseudotyped virus Research respiratory resulting SARS-CoV-2 SARS-CoV-2 virus secreted Serological assay serological assays severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome virus stomatitis surrogate Surrogates vaccination Vaccine vesicular stomatitis vesicular stomatitis virus virus Virus neutralization VSV while [DOI] 10.1128/Spectrum.01059-21 PMC 바로가기 [Article Type] Research Article
An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between catsArticle Published on 2021-10-202022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] addition Animal host Antigen approach B.1.1.7 variant clinical disease close contact Critical detrimental develop effective Epidemiology expressing Human induce Infection infection with SARS-CoV-2 Infectious diseases Infectious virus mutations nasal swab Neutralizing antibody response neutralizing antibody responses Oropharyngeal pandemic Particle Prevent protective immunity raised reduce replicon reported required risk RNA vaccines Safe SARS-CoV-2 SARS-COV-2 infection spike Spread spread to susceptible the SARS-CoV-2 Transmission transmission of SARS-CoV-2 Vaccine vaccine candidate variety Venezuelan equine encephalitis virus [DOI] 10.1038/s41541-021-00390-9 PMC 바로가기 [Article Type] Article
Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism케냐의 COVID-19 전파에 대한 수학적 모델링: 재감염 전파 메커니즘이 있는 모델Research Article Published on 2021-10-162022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] MERS, SARS, 치료기술, [키워드] Admission Alter Asymptomatic Asymptomatic case Asymptomatic cases Asymptomatic individuals Contact tracing coronavirus disease Coronavirus disease 2019 COVID-19 COVID19 Critically ill cumulative dataset deaths detection rate Face masks fitting increase in individual infectious intensive care Kenya lead mathematical mathematical model Mild symptom mild symptoms Model pandemic parameter pharmaceutical intervention Prevalence proliferation protective immunity reduce Reinfection reported severe symptom severe symptoms subpopulation symptomatic symptomatic individual symptomatic individuals wearing face mask with COVID-19 [DOI] 10.1155/2021/5384481 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjectsSARS-CoV-2 특정 기억 T 세포 에피토프가 COVID-19 회복 대상에서 확인됨Article Published on 2021-10-152022-09-11 Journal: Virus research [Category] SARS, 치료법, [키워드] Activation Analysis B cell caused CD4 CD8 T cell Cell Coronaviral COVID-19 COVID-19 pandemic COVID-19 vaccine design defined ELISPOT enzyme enzyme-linked immunosorbent epitope epitope mapping Epitopes evaluated examined explicit flow cytometry followed by foundation glycoprotein HLA Hope host immunity IgG immune immune responses immunodominant epitopes immunogenic immunogenicity in some individual induce mapped memory T memory T cells mononuclear cell N protein neutralizing antibody Neutralizing antibody response neutralizing antibody responses nucleocapsid nucleoprotein Outbreaks PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells positively correlated proportion protective immunity Protein public health RBD receptor Receptor-binding domain Reinfection response robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S spike spike glycoprotein stimulate structural proteins subject subjects T cell T cell activation T cell epitope T cell epitopes T cell response T cell responses T cells the receptor-binding domain the S protein Therapeutics vaccination Vaccine Vaccine design virus-specific T cell virus-specific T cell responses were used [DOI] 10.1016/j.virusres.2021.198508 PMC 바로가기 [Article Type] Article
Seroprevalence of SARS-CoV-2 in Croatian solid-organ transplant recipientsShort Communication Published on 2021-10-152022-10-27 Journal: Biochemia Medica [Category] COVID-19, [키워드] acute respiratory syndrome addition anti-SARS-CoV-2 antibody Antibody titer asymptomatic patient collected Community coronavirus coronavirus disease COVID-19 COVID-19 immunity COVID-19 pandemic Croatia cross-sectional determine ELISA enzyme-linked immunosorbent event IgG Immunocompromised interquartile range IQR kidney transplant recipient liver LTR material median Patient Population positive positive patient positive sample protective immunity questionnaire recipient reported Result risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 IgG antibody Seroprevalence serum sample significantly higher solid-organ transplant solid-organ transplant recipients Spain statistically significant Symptom symptomatic tested virus neutralization test VNT was performed [DOI] 10.11613/BM.2021.030901 PMC 바로가기 [Article Type] Short Communication