Proteins – Page 15 – Communicable Diseases Research

Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals

세로 방향 면역 프로파일링은 COVID-19 회복기 개인의 장기 체액성 면역을 매개하는 지배적인 에피토프를 나타냅니다

Article

Published on 2022-04-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단,

Molecular phylogeny of coronaviruses and host receptors among domestic and close-contact animals reveals subgenome-level conservation, crossover, and divergence

국내 및 밀접 접촉 동물 사이의 코로나바이러스 및 숙주 수용체의 분자 계통 발생은 하위 게놈 수준의 보존, 교차 및 분기를 나타냅니다

Article

Published on 2022-04-012022-09-11
Journal: BMC veterinary research [Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE2 ACE2 residue acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphacoronavirus alphacoronaviruses aminopeptidase N analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animals APN binding cathepsin L cattle Comparative Comparative phylogeny Complete conservation conserved Consistency coronavirus Coronavirus-2 Coronaviruses Critical cross determine dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 enzyme Enzymes events explain Factor furin furin cleavage furin cleavage motif genome sequence Genome sequences Host host receptor Host receptors hosts identify infecting intermediate host Intersection membrane MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular N protein N proteins nucleocapsid offer other coronavirus other coronaviruses Phylogenetic tree phylogenies Phylogeny polybasic Protein Protein binding Proteins receptor receptors Recombination respiratory syndrome coronavirus retained reveal S proteins S, E, M, and N proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SAS segregation sequence Serine Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sialic acid similarities similarity spike Spike protein Support the S protein theory TMPRSS2 transmembrane serine protease transmembrane serine protease 2 unique Viral protein Viral proteins virus white-tailed deer β-coronavirus
[DOI] 10.1186/s12917-022-03217-4 PMC 바로가기 [Article Type] Article

In silico analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties

특정 플라보노이드와 2019년 신종 코로나바이러스 수용체 결합 도메인의 상호작용 및 세포성 프로테아제 및 이들의 약동학적 특성에 대한 실리코 분석

Article

Published on 2022-04-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제,

[키워드] 2019 2019 novel coronavirus 2019-nCoV acute respiratory syndrome coronavirus Analysis binding blood-brain barrier cathepsin B caused cellular protease cellular proteases Compound conducted coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 death drug-likeness eukaryotic cells evaluated FIVE flavonoid flavonoids gallate glycoprotein hepatotoxicity hydrogen Hydrogen bond inhibit Interaction interactions microorganism MM/PBSA molecular molecular docking molecular dynamics Molecular mechanics nCoV P-glycoprotein pharmacokinetic Protein Proteins RBD Receptor binding domain respiratory SARS-CoV-2 Serine serine protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike glycoprotein subgroup substrate supported surface area target proteins the receptor-binding domain TMPRSS2 Toxicity transmembrane serine protease transmembrane serine protease 2 Van
[DOI] 10.1080/07391102.2020.1840444 PMC 바로가기 [Article Type] Article

Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions

생리학적 및 병리학적 조건에서 골수 세포에서 MS4A 패밀리 구성원의 차등 발현 및 조절

Article

Published on 2022-04-012022-09-11
Journal: Journal of leukocyte biology [Category] MERS, 바이오마커,

[키워드] Analysis Arthritis Bioinformatics analysis CD20 cellular circulating monocyte circulating monocytes circulating neutrophils COVID-19 differentially expressed ENCODE expressed expression family family members functional gene expression regulation gene family glucocorticoid Hormones immature Immunity in vitro increase in marker monocyte Monocytes monocytes/Mϕs MS4A1 MS4A14 MS4A2 MS4A3 MS4A4A MS4A4E MS4A6A MS4A7 myeloid cell myeloid cells myeloid precursors Neutrophils pathological condition patients physiological Protein Proteins regulated Regulation reported rheumatoid arthritis RT-PCR severe disease therapeutic targets tissue were expressed
[DOI] 10.1002/JLB.2A0421-200R PMC 바로가기 [Article Type] Article

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

SARS-CoV-2 단백질에 대한 BioID 파생 근접 상호작용체

Article

Published on 2022-03-152022-09-11
Journal: Viruses [Category] SARS, 신약개발, 유전자 메커니즘,

[키워드] Analysis antiviral therapies antivirals assist association BioID caused Cell cells cellular cellular pathway COVID-19 COVID-19 pandemic drug library enrichment analysis expressing Follow-up Functional enrichment analyses Health Host host cell host cells human lung identify Interaction interactome labeling lung cancer mechanism Novel coronavirus novel coronavirus SARS-CoV-2 Pathogenesis Protein Proteins proteome proteomic proximity labeling. reported responsible SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 proteins SARS-CoV-2 viral the SARS-CoV-2 TurboID understanding valuable resource Viral proteins was used website
[DOI] 10.3390/v14030611 PMC 바로가기 [Article Type] Article

Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing

SARS-COV-2 감염 및 약물 용도에 영향을 미치는 기능, 경로 및 조절제를 강조하는 숙주 게놈 바이오 마커의 계산 식별

Article

Published on 2022-03-112022-08-31
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 신약개발, 치료제,

[키워드] 3CL Analysis analyzed binding affinities Biomarker candidate drugs Computational biology and bioinformatics control sample COVID-19 CXCL2 daclatasvir DEGs differentially expressed gene docking drug Drug discovery drug target drugs Economy effective enrichment analysis FDA approved Drugs function functional functions genomic GUCY1A2 highlighting Host hub-genes identify IGF2 independent indicate infections Interaction investigated IRF7 Ivermectin KEGG pathway KLF6 life miRNA miRNAs molecular docking analysis NEDD9 network analysis PAG1 pandemic pathway Pathways performed PPI Protein Protein–protein interaction Proteins Radotinib Rapamycin receptor receptor protein receptor proteins receptors reduced RNA sequence SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Seven signaling pathway signaling pathways significantly SNRPD2 stability Stat1 Systems biology tacrolimus the SARS-CoV-2 Thiostrepton TLR2 transcriptomics Treatment USP53 vaccination variants of SARS-CoV-2 ZFP36
[DOI] 10.1038/s41598-022-08073-8 PMC 바로가기 [Article Type] Article

A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS-CoV-2 Variants of Concern

다양한 SARS-CoV-2 변이체의 스파이크 단백질을 인식하는 범용 DNA 앱타머

Article

Published on 2022-03-102022-09-11
Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제,

In silico discovery of 3 novel quercetin derivatives against papain-like protease, spike protein, and 3C-like protease of SARS-CoV-2

Research

Published on 2022-03-092022-10-30
Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19,

[키워드] 3CLpro Analysis Anti-inflammatory antioxidant Antiviral antiviral activity antiviral drug AutoDock binding binding affinity binding energy complexes Compound conducted Coordinate coordinates coronavirus COVID-19 disease database derivative docking domain drug-likeness Efficacy evaluate filtered highest highest binding affinity identify immune Immunity immunomodulatory Interaction Kyoto Ligand modulated modulation molecular docking normal normal mode analysis Papain-like protease pathway physical PLPro positive predicted protease Protein protein-ligand Proteins quercetin quercetin derivatives Remdesivir reported responsible Result SARS-CoV-2 scored Simulation study Spike protein stability Standard target was done was performed was used were recorded
[DOI] 10.1186/s43141-022-00314-7 PMC 바로가기 [Article Type] Research

Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes

게놈 전반에 걸친 분석을 통해 SARS-CoV-2 바이러스 유전자 Orf9c가 인간 다능성 줄기 세포 유래 심근세포에 미치는 해로운 영향을 보여줍니다

Article

Published on 2022-03-082022-09-11
Journal: Stem Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법,

[키워드] Abnormalities abnormality acute respiratory syndrome acute respiratory syndrome coronavirus ameliorated analyses Analysis Apoptosis apoptotic approved ATP ATP synthesis cardiac dysfunction cardiac injury cardiomyocyte caused Cell cellular characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death defined detrimental detrimental effect detrimental effects disease down-regulated drug Drug administration dysfunction electrical ENCODE expression Factor Factors food functional Genes Genome heart disease heart muscle human pluripotent stem cell Impact Inflammation Injury Ivermectin manifestation Manifestations meclizine meclizine. molecular mechanism molecular mechanisms Orf9c overexpression Pathways Protein Proteins Proteomic analysis reduced respiratory restored SARS-CoV-2 SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly stem cell Therapeutic approach Transcriptomic analyses transcriptomic analysis U.S. Food and Drug Administration up-regulated
[DOI] 10.1016/j.stemcr.2022.01.014 PMC 바로가기 [Article Type] Article

Oxidative stress and inflammatory markers in patients with COVID-19: Potential role of RAGE, HMGB1, GFAP and COX-2 in disease severity

COVID-19 환자의 산화 스트레스 및 염증 표지자: 질병 중증도에서 RAGE, HMGB1, GFAP 및 COX-2의 잠재적 역할

Observational Study

Published on 2022-03-012022-09-11
Journal: International immunopharmacology [Category] SARS, 바이오마커, 임상,

[키워드] Acidic addition All participants Blood blood sample Blood samples cellular response Clinical studies clinical study Control correlation COVID-19 COVID-19 pathogenesis COX-2 Critical cyclo-oxygenase cytokine Cytokines determine disease severity dysregulated end products evaluate form GFAp healthy controls HMGB1 hyperinflammatory state ICU immune implicated individual induce Inflammation Inflammatory marker intensive care intensive care unit lack lead marker Mild mild to moderate mild to moderate symptoms moderate Neurological dysfunction observational study Outpatient outpatients overexpression oxidative oxidative stress participant Patient patients with COVID-19 Potential Protein Proteins RAGE receptor receptor for advanced glycation end products respiratory respiratory viral infection respiratory viral infections risk of death SARS-COV-2 infection severity significant increase Stress Symptoms upregulation Viral viral infections was used western blot with COVID-19
[DOI] 10.1016/j.intimp.2021.108502 PMC 바로가기 [Article Type] Observational Study