Decreased dengue transmission in migrant worker populations in Singapore attributable to SARS-CoV-2 quarantine measuresOriginal Article Published on 2021-03-032022-10-31 Journal: Journal of Travel Medicine [Category] COVID-19, Fulltext, MERS, [키워드] age Arboviruses Asia conditions COVID-19 Decreased determine Effect examined expected highlight measure migrant worker Non-pharmaceutical interventions Population quarantine reduced risk reduction reported Result risk risk reduction SARS-CoV-2 Singapore social distancing social distancing measures Transmission was used [DOI] 10.1093/jtm/taaa228 PMC 바로가기 [Article Type] Original Article
Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection심각한 SARS-CoV-2 감염 위험과 혈청 HDL-콜레스테롤 및 아포지단백 A1 수치의 연관성Multicenter Study Published on 2021-03-022022-09-10 Journal: Journal of Lipid Research [Category] 바이오마커, 변종, [키워드] 95% CI, 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age allele alleles ApoA1, apolipoprotein A1 APOE4 apolipoprotein A1 association Biomarker CAD, coronary artery disease cholesterol clinical risk factor Clinical risk factors Coronary artery Coronary artery disease coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19, Coronavirus disease 2019 cumulative cumulative effects diabetes Effect elevated evaluated Evidence feature genetic risk score Genetic variant genetic variants GRS, genetic risk scores HDL-cholesterol higher risk homozygous hypertension ICD-10, International Classification of Diseases, Tenth Revision increase in individual Infection investigated Logistic regression analyses Logistic regression analysis mendelian randomization Mendelian randomization analyses Mendelian randomization analysis metabolic syndrome Mortality MR, Mendelian randomization MVMR, multivariate MR negative controls Novel coronavirus obesity OR, odds ratio outcomes PC, principal component reduced risk respiratory Respiratory disease risk SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 serum serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection severe respiratory disease severe SARS-CoV-2 severity of COVID-19 Sex susceptible syndrome type 2 diabetes UK biobank were used [DOI] 10.1016/j.jlr.2021.100061 PMC 바로가기 [Article Type] Multicenter Study
Comparing ICU admission rates of mild/moderate COVID-19 patients treated with hydroxychloroquine, favipiravir, and hydroxychloroquine plus favipiravir하이드록시클로로퀸, 파비피라비르, 하이드록시클로로퀸과 파비피라비르를 병용한 경증/중등도 COVID-19 환자의 ICU 입원률 비교Observational Study Published on 2021-03-012022-09-11 Journal: Journal of infection and public health [Category] 임상, 치료제, [키워드] adjusted Admission age Analysis applied approach city clinics Combination conducted covariate COVID-19 COVID-19 patient diagnosis of COVID-19 disease effect of treatment effect size eligible Favipiravir group HCQ Hospitalized Hydroxychloroquine ICU ICU admission ICU admission rate indicated intensive care intensive care unit Laboratory median age Mild Mild disease mild to moderate Moderate COVID-19 Multivariate analysis no statistically significant difference observational study Patient patients patients hospitalized Pneumonia Probability Propensity score propensity scores ranged reduced risk retrospective sensitivity analysis significantly higher statistically statistically significant difference study period the patient treated Treatment treatment group variable was used Weighting [DOI] 10.1016/j.jiph.2020.12.017 PMC 바로가기 [Article Type] Observational Study
Drug Repurposing in the COVID-19 Era: Insights from Case Studies Showing Pharmaceutical PeculiaritiesReview Published on 2021-02-252022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] administration Antiviral Antiviral effect approved benefit chloroquine/hydroxychloroquine Clinical improvement COVID-19 death dietary supplements drug Drug repurposing drugs effective Efficacy heparin high risk highlight Hydroxychloroquine insight Lopinavir/ritonavir Mortality Older Ozone patients pharmaceutical pharmaceutical formulations pharmacokinetic phosphodiesterase inhibitors potential treatments reduced risk Regulatory Remdesivir reported repurposing Safe safety profile Severe respiratory distress syndrome tested treatments for COVID-19 [DOI] 10.3390/pharmaceutics13030302 PMC 바로가기 [Article Type] Review
Concentration and Quantification of SARS-CoV-2 RNA in Wastewater Using Polyethylene Glycol-Based Concentration and qRT-PCRProtocol Published on 2021-02-232022-10-30 Journal: Methods and Protocols [Category] COVID-19, [키워드] can be used Community Concentration COVID-19 determine Efficiency environmental samples Epidemiology equipment glycol inhibit majority Outbreaks physico-chemical property polyethylene public health qRT-PCR qRT-PCR assay Quantitative reduced risk reverse transcription PCR RNA extraction SARS-CoV-2 SARS-CoV-2 RNA sewage subsequent Surveillance target Variation Viral detection viral disease virus wastewater wastewater virology [DOI] 10.3390/mps4010017 PMC 바로가기 [Article Type] Protocol
Focused Review: Potential Rare and Atypical Symptoms as Indicator for Targeted COVID-19 Screening집중 검토: 표적 COVID-19 선별 검사의 지표로서 잠재적인 희귀 및 비정형 증상Review Published on 2021-02-232022-09-10 Journal: Medicina [Category] MERS, 진단, 치료기술, 치료제, [키워드] Affect affected alertness Atypical atypical symptom concerning Contact contact with coronavirus disease Coronavirus disease 2019 Coronavirus-2 cough COVID-19 COVID-19 patients COVID-19 symptom detection diarrhea ENhance Fever global pandemic healthcare healthcare personnel Healthcare professional healthcare professionals Indicator Infection infections information knowledge lead nausea nausea and vomiting neurological ocular Patient patients Potential Precaution reduced risk reported respiratory respiratory syndrome coronavirus SARS-CoV-2 Screening severe respiratory syndrome Shortness of breath Symptoms these symptom these symptoms vomiting [DOI] 10.3390/medicina57020189 PMC 바로가기 [Article Type] Review
Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers의료 종사자에서 SARS-CoV-2 감염의 항체 상태 및 발생률Article Published on 2021-02-112022-09-11 Journal: The New England Journal of Medicine [Category] MERS, SARS, 진단, 치료법, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted age anti-Nucleocapsid IgG Anti-spike anti-spike antibodies anti-Spike IgG antibody antibody status assays Asymptomatic baseline baseline antibody status Chain Reaction changes in Combination coronavirus Department determine determined by Follow-up Gender Health care Health care worker incidence incidence rate investigated occurred Oxford participated PCR PCR-positive polymerase chain polymerase chain reaction positive positive PCR test presence of antibody primary analysis rate ratio rate ratios reduced risk Reinfection respiratory risk SARS-CoV-2 SARS-COV-2 infection Seroconversion seronegative seropositive severe acute respiratory syndrome Coronavirus status subsequent symptomatic symptomatic infection symptomatic infections test results tested United Kingdom university was determined was used worker [DOI] 10.1056/NEJMoa2034545 PMC 바로가기 [Article Type] Article
Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study Research Published on 2021-02-042022-10-05 Journal: Molecular Psychiatry [Category] SARS, 임상, 진단, 치료제, [키워드] 95% CI adjusted adults hospitalized Analysis Antiviral effect AP-HP association biological marker Characteristics conducted COVID-19 Cox model death depressive disease severity disorder Endpoint epithelial cell examined Hospital admission hospitalized patient hospitals In-vitro Infection inhibit intubation lower risk medication Meta-analysis multicenter multiple sensitivity analyses multivariable Paris Patient patients hospitalized plasma Prevent primary analysis primary endpoint pro-inflammatory mediators Probability psychotropic medications randomized clinical trial recent reduced reduced risk remained retrospective cohort study SARS-CoV-2 severe COVID-19 university Weighting [DOI] 10.1038/s41380-021-01021-4 [Article Type] Research
Distinct Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent IndividualsSARS-CoV-2 회복기 환자의 전신 및 점막 체액 면역의 특징 및 기능Immunology Published on 2021-01-282022-09-12 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, 진단, [키워드] antibody Antibody Response cohorts contribute convalescent individual correlated correlations COVID-19 Critical experiment function Hospitalization humoral immune response IgA IgA responses IgG Immunity individual Infection less magnitude mucosa mucosal mucosal immunity nasal natural infection neutralization phagocytosis public health reduced risk robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG serum severe disease Severity of disease Support systemic systems serology understanding Vaccine Vaccine development Virus neutralization [DOI] 10.3389/fimmu.2020.618685 PMC 바로가기 [Article Type] Immunology
Corticosteroid treatment has no effect on hospital mortality in COVID-19 patientsArticle Published on 2021-01-132022-10-04 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] adjusted Admission association Cohort cohort of patient cohort study confounders Corticosteroid corticosteroid therapy Corticosteroids COVID-19 COVID-19 pandemic COVID-19 patient died drug therapy evaluate Evidence hospital Hospital stay ICU admission in-hospital mortality Infectious diseases intensive care unit knowledge Mortality not affect Novel coronavirus overlap weight pandemic Patient patients hospitalized patients with COVID-19 positive RT-PCR reduce reduced risk reducing resources SARS-CoV-2 subject Treatment with COVID-19 [DOI] 10.1038/s41598-020-80654-x PMC 바로가기 [Article Type] Article