Genome Hotspots for Nucleotide Substitutions and the Evolution of Influenza A (H1N1) Human StrainsLetter Published on 2016-04-172023-06-23 Journal: Genome Biology and Evolution [Category] 신종인플루엔자, [키워드] antigenic drift extinction Influenza Selection substitution hotspots [DOI] 10.1093/gbe/evw061 PMC 바로가기 [Article Type] Letter
Bovine Host Genetic Variation Influences Rumen Microbial Methane Production with Best Selection Criterion for Low Methane Emitting and Efficiently Feed Converting Hosts Based on Metagenomic Gene Abundance소 숙주 유전자 변이는 메타게놈 유전자 풍부도를 기반으로 하는 낮은 메탄 방출 및 효율적인 사료 전환 숙주에 대한 최상의 선택 기준으로 반추위 미생물 메탄 생산에 영향을 미칩니다.Research Article Published on 2016-02-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abundance analysed Analysis animals anthropogenic anthropogenic activities archaeal can be used cattle contribute Control criterion cross talk crossbred diet Effect effective experiment explained feed conversion efficiency fmdB FucI functional gene gastrointestinal tract Genes Genetic genetic analysis genetic control genetic influence genetic link genetic link controlling genetic selection genetics greenhouse gas greenhouse gas emissions group Health Host hosts idea implementation influence mcrA metabolism metagenome metagenomic metagenomic profiling Methane methane emission methane emissions Methanogenesis methanogenic archaea microbial Microbiome microbiota nutrition open predict principle produced Production progeny proof provide provided ranking respiration chambers Rumen ruminal ruminal digesta ruminant ruminants Selection shown significantly species suggested traits TSTA3 Variation [DOI] 10.1371/journal.pgen.1005846 PMC 바로가기 [Article Type] Research Article
Strong Selection at MHC in Mexicans since Admixture혼합 이후 멕시코의 MHC에서 강력한 선택Research Article Published on 2016-02-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence admixture African allele Analysis average coefficient Cohort credibility datasets dbGaP debate detect deviate difficulty European Europeans flexibility genetic difference Genome Genome-wide association study hallmark Haplotype humans inaccuracy Latino Local medical history Mexican Mexicans MHC performed populations Region reported Selection significantly statistical model Strong subject Taking the strongest [DOI] 10.1371/journal.pgen.1005847 PMC 바로가기 [Article Type] Research Article
Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 ( IFNL4 )개선된 바이러스 제거와 관련된 변이체에 대한 선택은 인터페론 람다 4(IFNL4)의 국소적 적응형 가성화를 유도합니다.Research Article Published on 2014-10-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ABC adaptive allele America Antiviral antiviral activity approach Approximate Asia Asian association Bayesian clearance complex conserved disease drive driving East Elimination ENCODE environmental force Europe European Evidence evidence of fixation Frame Frequency functional Genetic genetic association Genetic variant Genetic variation groups HCV hepatitis C hepatitis C virus heterogeneity Human human populations IFN-λ IFNL4 Improved inactivation Infection insertion Interferon lambda Lambda mammal mammals Migration moderate Mutation Open reading frame phenotype phenotypic diversity Population populations positive Positive selection Protein provide pseudogene raise raising reached resulting Selection selective SNP SNPs strength susceptibility the strongest turn variant virus [DOI] 10.1371/journal.pgen.1004681 PMC 바로가기 [Article Type] Research Article
Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa인간 아연 수송체 ZIP4(SLC39A4)의 극단적인 인구 차이는 사하라 사막 이남의 아프리카에서 양성 선택으로 설명됩니다Research Article Published on 2014-02-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accompanied acrodermatitis acrodermatitis enteropathica African allele allele frequencies allele frequency Amino acid Author biological function Cell characterized classical computer simulations Concentration deficiency derived allele difference different directional disease phenotype disease risk DNA Evidence explained expression extreme finding fixation found functional Genetic Health HeLa cells homeostasis hotspot Human human population human populations implication intestinal investigated isoform leucine Local locus membrane Mutation natural selection Neanderthal Non-synonymous overexpression pathogen Pathogens polymorphism Population positive Positive selection Protein Recombination reduced reducing regulated Regulation Research Selection selective sweep significantly SLC39A4 sub-Saharan Africa surface protein Trace element transporter valine variant West Zinc zinc deficiency [DOI] 10.1371/journal.pgen.1004128 PMC 바로가기 [Article Type] Research Article
VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human virusesResearch Published on 2013-12-112022-10-30 Journal: Journal of Translational Medicine [Category] Coronavirus, [키워드] 0.05 Algorithm ANN antiviral therapeutics approach coefficient condition correlation cross dataset datasets effective Efficacy feature frequencies HBV HCV heterogeneous HIV independent mammalian nucleotide Pearson performed predicted Prediction algorithm predictor Quantitative REP Result RNAi secondary structure Selection sequence siRNA siRNAs Support SVM tested thermodynamic tree virus virus [DOI] 10.1186/1479-5876-11-305 PMC 바로가기 [Article Type] Research
Evolutionary interactions between haemagglutinin and neuraminidase in avian influenzaResearch Article Published on 2013-10-092023-05-31 Journal: BMC Evolutionary Biology [Category] Fulltext, 조류인플루엔자, [키워드] Evolution Influenza Reassortment Selection subtype [DOI] 10.1186/1471-2148-13-222 PMC 바로가기 [Article Type] Research Article
Chromosomal Copy Number Variation, Selection and Uneven Rates of Recombination Reveal Cryptic Genome Diversity Linked to Pathogenicity염색체 복사 수 변이, 선택 및 재조합의 불균등한 비율은 병원성과 관련된 비밀 게놈 다양성을 나타냅니다Research Article Published on 2013-08-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive addition analysis asexual association Author Batrachochytrium dendrobatidis change changes in characterized chromosomal chromosome contribute contributed copy copy number Culture de novo directional Diversity ecological niche ecological niches effort Evidence evidence of Evolution explain Factors feature fungal fungi Gene Genetic Genome genomes growth Host hot spots in vitro infect isolate knowledge Lineage lineages majority manifested mechanism microbial number occur organism pathogen pathogenicity Pathogens phenotypic ploidy Rate Recombination Region replicate reported reproduction response Secretome Selection sequenced target Transmission Variability Variation virulence virulence factors widespread [DOI] 10.1371/journal.pgen.1003703 PMC 바로가기 [Article Type] Research Article
Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies서아프리카 피그미족의 조상 패턴, 자연 선택의 서명 및 키와의 유전적 연관성Research Article Published on 2012-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive African Anatomy ancestry approach association Author average candidate gene chromosome chromosome 3 CISH Cluster cytokine cytokine signaling demography DOCK3 enrichment European Europeans Evolution extreme found Gene Genetic genetic association genetic diversity Genome genomic region globe group growth growth factor growth hormone Height highest Human human population human populations identify Illumina Immunity include indicate inhibit insulin insulin-like growth factor involved Local location loci metabolism natural natural selection neuroendocrine Pathway analysis Pathways pattern phenotypic phenotypic diversity phenotypic variation Physiology Population Positive selection Region regulate reproduction Selection short stature Signaling signaling pathways signature SNP stature target targets the strongest thought tropical unique variant variants Variation [DOI] 10.1371/journal.pgen.1002641 PMC 바로가기 [Article Type] Research Article