Using mobility data in the design of optimal lockdown strategies for the COVID-19 pandemicResearch Article Published on 2021-08-122022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, SARS, [키워드] applicability Approximate Bayesian concerning COVID-19 pandemic data-driven dataset effective England epidemiological Factors France Google mobility data Healthcare system implementation information lockdown lockdown policy mathematical methodology performed Predictive provide public health Quantitative quarantine real time reduced reduction resulting robust Schools shown Spread structures the epidemic Travel [DOI] 10.1371/journal.pcbi.1009236 PMC 바로가기 [Article Type] Research Article
Psychometric Validation of the Arabic Fear of Illness and Virus EvaluationArticle Published on 2021-08-122022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Affect Analysis Anxiety Arabic Behavior COVID-19 demographics evaluate examined Factor fear FIVE illness Impact indicated internal consistency life Other Outbreaks Pandemics participant positive correlation psychological Impact psychometric property Psychometric validation questionnaire recruit reliability robust Saudi Arabia scale Structure structures suggested translated translation validation Validity was used [DOI] 10.3390/ijerph18168529 PMC 바로가기 [Article Type] Article
A computational study of cooperative binding to multiple SARS-CoV-2 proteinsArticle Published on 2021-08-112022-10-04 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Anti-viral approaches binding Chinese Compound Computational chemistry docking drug drug design effective effort eight Evidence facilitated Interaction investigated methodology molecular simulations Protein Proteins RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins Small molecules Spread structures the SARS-CoV-2 virus the Spike these compound variants viral infection Virtual screening virus while [DOI] 10.1038/s41598-021-95826-6 PMC 바로가기 [Article Type] Article
Interactions of Spike-RBD of SARS-CoV-2 and Platelet Factor 4: New Insights in the Etiopathogenesis of ThrombosisSARS-CoV-2의 Spike-RBD와 혈소판 인자 4의 상호 작용: 혈전증의 병인 발생에 대한 새로운 통찰력Communication Published on 2021-08-092022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] ACE2 administration adverse event aggregation anti-spike antibodies antibodies antibody binding biochemical conditions contrary cross-reactivity develop diagnosed ELISA assays evaluated evidenced expression Factor Frequency heparin insight Interaction involved much higher New pathogenic Patient PF4 Platelet platelet factor 4 Platelets pro-thrombotic Protein RBD proteins recognize reported SARS-CoV-2 SARS-CoV2 severe COVID-19 similarities similarity specific antibodies specific antibody spike Spike protein Spike-RBD Structure structures syndrome the patient therapy These data thrombocytopenia thrombosis vaccination Vaccine [DOI] 10.3390/ijms22168562 PMC 바로가기 [Article Type] Communication
COVID-19 admission risk tools should include multiethnic age structures, multimorbidity and deprivation metrics for air pollution, household overcrowding, housing quality and adult skillsRespiratory Infection Published on 2021-08-092022-10-28 Journal: BMJ Open Respiratory Research [Category] COVID-19, MERS, SARS, [키워드] affecting African age AUC calculated Characteristics clinical risk cohort study Control COVID-19 COVID-19 admission Critically ill patient CURB65 Deprivation Deterioration determinant form Health highest hospitalised hospitalised patient household ICU admission include index ISARIC4C living environment Metrics Mortality mortality risk factors Multimorbidity Multiple obesity operator Patient Pneumonia presenting receiver researcher respiratory infection Result risk risk factor score Sex Structure structures viral infection White patient with COVID-19 [DOI] 10.1136/bmjresp-2021-000951 PMC 바로가기 [Article Type] Respiratory Infection
Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies매우 강력하고 고온에 견디며 돌연변이에 내성이 있는 나노바디에 의한 SARS-CoV-2 중화Article Published on 2021-08-092022-09-10 Journal: The EMBO Journal [Category] MERS, SARS, 변종, 진단, [키워드] Alpha alternative antibodies antibody best Beta bind Concentration concentrations Coronaviridae COVID‐19 COVID‐19 patients COVID‐19 cytosol E484K effective Epsilon Gamma immune Immunoglobulin immunoglobulins immunology include Interaction Iota L452R lineages mammalian cell mammalian cells microbial Microbiology, Virology & Host Pathogen Interaction monomer mutant strain Mutation N501Y nanobodies nanobody neutralization neutralize open Protein RBD receptor‐binding domain SARS‐CoV‐2 SARS‐CoV‐2 spike SARS‐CoV‐2 Spike protein structures the RBD the Spike Treatment trimer Vaccine VHH antibody Viral [DOI] 10.15252/embj.2021107985 PMC 바로가기 [Article Type] Article
Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformersArticle Published on 2021-08-062022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, SARS, [키워드] applied conformational cryo-EM drug target favor form frameshift heterogeneity highlight implication Ion mechanism Molecular conformation optical probe promote required respond ribosomes rigidity RNA SARS-CoV-2 Single-molecule biophysics stability stimulate Structure structures tension the SARS-CoV-2 thought topologies translation [DOI] 10.1038/s41467-021-25085-6 PMC 바로가기 [Article Type] Article
Deep learning of contagion dynamics on complex networksArticle Published on 2021-08-052022-10-29 Journal: Nature Communications [Category] Coronavirus, MERS, SARS, [키워드] Accuracy applicability Applied mathematics approach assumption build complementary Complex network Complex networks Contagion COVID-19 outbreak data-driven deep deep learning effective Epidemic Evolution Forecasting Local mechanism offer Perspective prediction Quantitative Spain structures training data [DOI] 10.1038/s41467-021-24732-2 PMC 바로가기 [Article Type] Article
Deep geometric representations for modeling effects of mutations on protein-protein binding affinityResearch Article Published on 2021-08-042022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, [키워드] addition Amino acid approach binding affinity change dataset datasets deep develop drug design Effect effort ENCODE experiments feature functional geometric in silico Approach Interaction labor-intensive modeling Mutation mutations predict Protein protein complex Protein design protein-protein interaction Proteins RBD Research SARS-CoV-2 antibody structures the binding affinity the receptor-binding domain the S protein three-dimensional structure time-consuming Topology [DOI] 10.1371/journal.pcbi.1009284 PMC 바로가기 [Article Type] Research Article
Efficient machine learning model for predicting drug-target interactions with case study for Covid-19COVID-19에 대한 사례 연구와 약물-표적 상호 작용을 예측하기위한 효율적인 기계 학습 모델Article Published on 2021-08-012022-08-31 Journal: Computational biology and chemistry [Category] MERS, SARS, 신약개발, 치료기술, 치료제, [키워드] Accuracy ACE2 protein affected Algorithm amino-acid amino-acid sequence applied can be used case study chemical properties computational method Corona virus Corona viruses COVID-19 COVID-19 infection cross dataset datasets Deep-learning develop drug drug treatment drug treatments drug-target interaction Drug-target interactions DrugBank drugs Effect effective efficient Ensemble learning experiment Experimental result experimental results f-score feature Infection input Interaction interactions labor labor-intensive Laboratory LINE machine machine learning performed physical physical and chemical properties predict predicted prediction Protein protein sequence protein sequences Proteins Structure structures System target time-consuming viruses [DOI] 10.1016/j.compbiolchem.2021.107536 PMC 바로가기 [Article Type] Article