Plasmodium cynomolgi infections in rhesus macaques display clinical and parasitological features pertinent to modelling vivax malaria pathology and relapse infections레서스 원숭이에서의 Plasmodium cynomolgi 감염은 비박스 말라리아 병리 및 재발 감염 모델링과 관련된 임상적 및 기생충학적 특징을 나타낸다.Research Published on 2016-09-022024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] Anaemia animal models host-pathogen interactions malaria non-human primates Plasmodium vivax rhesus Systems biology Thrombocytopaenia [DOI] 10.1186/s12936-016-1480-6 PMC 바로가기 [Article Type] Research
A spatial model of the efficiency of T cell search in the influenza-infected lungArticle Published on 2016-04-232023-06-23 Journal: Journal of theoretical biology [Category] 신종인플루엔자, [키워드] agent-based model Computational biology immunology Systems biology Virology [DOI] 10.1016/j.jtbi.2016.02.022 PMC 바로가기 [Article Type] Article
Heavy Path Mining of Protein-Protein Associations in the Malaria Parasite말라리아 기생충에서 단백질-단백질 연관성의 중량 경로 채굴Article Published on 2015-04-082024-08-26 Journal: Methods (San Diego, Calif.) [Category] 말라리아, [키워드] bioinformatics drug target Genomics heavy path mining malaria Systems biology [DOI] 10.1016/j.ymeth.2015.04.002 PMC 바로가기 [Article Type] Article
Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin [DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article
Lipidomics identifies a requirement for peroxisomal function during influenza virus replicationArticle Published on 2014-07-012023-06-14 Journal: Journal of Lipid Research [Category] Fulltext, 신종인플루엔자, [키워드] Biochemistry ether lipids glycerophospholipids lipid metabolism sphingolipids Systems biology [DOI] 10.1194/jlr.M049148 PMC 바로가기
Genome-scale metabolic reconstructions of multiple Escherichia coli strains highlight strain-specific adaptations to nutritional environments다수의 대장균 균주에 대한 유전체 규모 대사 회구는 영양 환경에 대한 균주별 적응을 강조한다.journal-article Published on 2013-12-102024-07-30 Journal: Microbial Cell Factories [Category] 세균성이질, [키워드] core and pan genome mathematical modeling Systems biology [DOI] 10.1073/pnas.1307797110 [Article Type] journal-article
Integrative genomic analysis of the human immune response to influenza vaccinationArticle Published on 2013-07-162023-06-08 Journal: eLife [Category] 신종인플루엔자, [키워드] Complex-trait genetic eQTL Human Human genetic Integrative biology Systems biology Vaccine [DOI] 10.7554/eLife.00299 PMC 바로가기
Microarray analysis of MicroRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1)Research Article Published on 2013-06-032023-05-24 Journal: BMC Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] 2009 H1N1 Influenza pandemic Critically ill patient Host pathogen interaction miRNA Systems biology [DOI] 10.1186/1471-2334-13-257 PMC 바로가기 [Article Type] Research Article
Understanding the immune response to seasonal influenza vaccination in older adults: a systems biology approachArticle Published on 2012-11-142023-06-23 Journal: Expert review of vaccines [Category] 신종인플루엔자, [키워드] bioinformatics Immunogenetics immunosenescence Influenza seasonal influenza vaccine Systems biology Vaccine-induced immunity vaccinomics [DOI] 10.1586/erv.12.61 PMC 바로가기 [Article Type] Article
Integrated network analysis reveals a novel role for the cell cycle in 2009 pandemic influenza virus-induced inflammation in macaque lungsResearch Article Published on 2012-08-312023-05-22 Journal: BMC Systems Biology [Category] Fulltext, 신종인플루엔자, [키워드] host response Influenza Microarray pH1N1 Systems biology [DOI] 10.1186/1752-0509-6-117 PMC 바로가기 [Article Type] Research Article