Comparative characterization of antibody responses induced by Ad5-vectored spike proteins of emerging SARS-CoV-2 VOCs신흥 SARS-CoV-2 VOC의 Ad5 벡터 스파이크 단백질에 의해 유도된 항체 반응의 비교 특성화Comparative Study Published on 2022-07-292022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] administration Alpha analyzed antibody Antibody Response Antibody responses B.1.351 B.1.429 B.1.617.2 Beta booster Characteristics Comparative cross-neutralizing antibody cross-reactivity Delta Effects elicit elicited Epsilon Gamma Heterologous immune response immune responses Lineage mice Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses omicron other variant other variants pandemic produced provided regimens responses against SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Single-dose spike Spike protein Spike proteins Spread stimulate the SARS-CoV-2 the vaccine unique vaccination Vaccination strategy Vaccine Vaccine development variants VoC VOCs [DOI] 10.1038/s41392-022-01065-0 PMC 바로가기 [Article Type] Comparative Study
Novel Coronavirus and Common Pneumonia Detection from CT Scans Using Deep Learning-Based Extracted Features딥 러닝 기반 추출 기능을 사용하여 CT 스캔에서 신종 코로나바이러스 및 일반적인 폐렴 감지Article Published on 2022-07-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy added Algorithm automatically average can be used Chest CT chest CT scan Chest CT scans China Classifier common common cold common pneumonia conditions Convolutional neural network convolutional neural network (CNN) Coronavirus pneumonia COVID-19 COVID-19 detection COVID-19 infection dataset deep deep learning deep learning features detect detection develop diagnose Diagnosis diagnostic test Extracted False-positive feature Health highest hospital Image individual infecting Intervention investigation knowledge MONITOR novel Novel coronavirus novel coronavirus pneumonia pandemic Pandemics Pneumonia Prevent reduce reported required Research severity Support support vector machine SVM Symptom Symptoms the disease the vaccine time-consuming treat Vaccine [DOI] 10.3390/v14081667 PMC 바로가기 [Article Type] Article
Efficacy and effectiveness of SARS-CoV-2 vaccines for death prevention: A protocol for a systematic review and meta-analysis사망 예방을 위한 SARS-CoV-2 백신의 효능 및 효과: 체계적인 검토 및 메타 분석을 위한 프로토콜Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, meta-analysis, SARS, [키워드] adverse event all-cause mortality analyzed approved assessment Bia calculated case-control studies case-control study Cohort controlled trials COVID-19 death deaths effective Effectiveness Efficacy Egger eligible Evidence exploratory for inclusion forest plot forest plots funnel plot hazard hazard ratios heterogeneity Hospitalization incident independent intervals Intervention Meta-analysis Mortality Observational data outcome Placebo Prevent Primary outcome PROSPERO protocol Publication bia publication bias randomized control trial Randomized controlled trials RCT Record reducing Registered risk reduction SARS-CoV-2 vaccine SARS-CoV-2 vaccines Secondary outcomes Severe case severe cases statistical statistical test systematic review the vaccine the vaccines university vaccination Vaccination Status Vaccine visual inspection York [DOI] 10.1371/journal.pone.0265414 PMC 바로가기 [Article Type] Article
Solanaceae Family Phytochemicals as Inhibitors of 3C-Like Protease of SARS-CoV-2: An In Silico AnalysisSARS-CoV-2의 3C 유사 프로테아제 억제제로서의 가지과 식물 화학물질: 실리코 분석Article Published on 2022-07-252022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] anthocyanidins anthocyanin anthocyanins Antiviral binding energy booster doses caused China Compound coronavirus SARS-CoV-2 country COVID-19 death derivative dose drug drugs Effectiveness eggplant examined family global pandemic in silico incanumine. Infection MPro phytochemical predicted protease Research resulting Russia SARS-CoV-2 SARS-CoV-2 replication silico studies Solanaceae the vaccine USA vaccinate Vaccine Vaccines virus Wuhan Wuhan, China [DOI] 10.3390/molecules27154739 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted with AS03: A randomised, placebo-controlled, observer-blinded phase 1/2 trialArticle Published on 2022-07-222022-10-06 Journal: EClinicalMedicine [Category] 진단, [키워드] adverse event adverse events anti-SARS-CoV-2 approach AS03 cellular immunity CEPI clinical study conducted COVID-19 COVID-19 pandemic deviation displaying distribution dose eligible Emergency use enrolled evaluate evaluated flu vaccine foundation geometric mean concentration group groups healthy hospital Humoral immunity IgG antibody immunogenic immunogenicity injection site pain Intervention intramuscularly Investment Local Melinda Gate mitigate myalgia naïve nanoparticle nanoparticle vaccine neutralizing antibody observer-blinded outcome participant per-protocol phase Placebo placebo-controlled primary immunogenicity Protein protocol pseudovirus randomised RBD RBD IgG reached reactogenicity receive recipient Recombinant protein recombinant protein vaccine Registered reported Safety SARS-CoV-2 SARS-COV-2 infection second dose Stage study enrollment Support supported systemic AE systemic AEs T-cell immune responses the receptor-binding domain the vaccine titre Trial vaccination vaccination schedule Vaccine wild-type virus World Health Organization [DOI] 10.1016/j.eclinm.2022.101569 PMC 바로가기 [Article Type] Article
Fast Prediction of Binding Affinities of SARS-CoV-2 Spike Protein and Its Mutants with Antibodies through Intermolecular Interaction Modeling-Based Machine Learning분자간 상호작용 모델링 기반 기계 학습을 통한 SARS-CoV-2 스파이크 단백질 및 항체와의 돌연변이체의 결합 친화도의 빠른 예측Article Published on 2022-07-212022-09-11 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] addition affinity antibodies antibodies binding antibody resistance Antibody therapeutics antigens approach artificial intelligence base binding binding affinities binding affinity COVID-19 Cryo-electron microscopy develop Effect help Interaction intermolecular interaction intermolecular interactions machine learning machine learning model machine learning models methodology modeling monoclonal antibodies monoclonal antibody mutant Mutation novel SARS-CoV-2 virus overcome pandemic predict prediction produced Receptor binding domain reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 virus spike Spike protein Structure the binding affinity the spike protein the vaccine variant variants of concern was used wild-type wild-type virus X-ray crystallography [DOI] 10.1021/acs.jpcb.2c02123 PMC 바로가기 [Article Type] Article
BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age5~11세 어린이의 오미크론에 대한 BNT162b2 백신 효과Article Published on 2022-07-212022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age BNT162b2 BNT162b2 vaccine calculated Care children Cohort Control controls coronavirus coronavirus disease Coronavirus disease 2019 cumulative cumulative incidence dominant variant dose Effectiveness eligible European event Evidence first dose Health Health care incidence Infection Kaplan-Meier estimator Limited Messenger RNA moderate of BNT162b2 omicron Omicron variant outcome provided risk risk difference risk ratio RNA vaccine SARS-CoV-2 SARS-COV-2 infection second dose severe acute respiratory syndrome Coronavirus study group study groups study period subgroups symptomatic COVID-19 the study group the vaccine union Vaccine vaccine doses Year [DOI] 10.1056/NEJMoa2205011 PMC 바로가기 [Article Type] Article
Estimation of vaccine efficacy for variants that emerge after the placebo group is vaccinated위약군 백신 접종 후 나타나는 변이체에 대한 백신 효능 추정Article Published on 2022-07-202022-09-11 Journal: Statistics in medicine [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] approach assumption clinical trial Cox regression demonstrated develop distribution Effects Efficacy estimation evaluate Follow-up hazard illustration misspecification Observational data Placebo placebo group Poisson proportion proportional hazards model proportions Randomized rare disease reflect SARS-CoV-2 Sensitivity analyses sensitivity analysis sieve analysis strain Strains Surveillance surveillance data the placebo group the vaccine vaccination Vaccine vaccine efficacy vaccine trial variant variants [DOI] 10.1002/sim.9405 PMC 바로가기 [Article Type] Article
Effectiveness and Cost-Effectiveness of Inactivated Vaccine to Address COVID-19 Pandemic in China: Evidence From Randomized Control Trials and Real-World Studies중국의 코로나19 팬데믹에 대처하기 위한 비활성화 백신의 효과 및 비용 효율성: 무작위 대조 시험 및 실제 연구의 증거Meta-Analysis Published on 2022-07-192022-09-11 Journal: Frontiers in Public Health [Category] 임상, [키워드] 95% CI address Analysis BBIBP-CorV China Chinese clinical trial CNKI combating Control CoronaVac cost-effectiveness COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine death determine effective Effectiveness Efficacy Evidence Factor Hospitalization hospitalizations ICU admission ICU admissions immunization inactivated Inactivated COVID-19 vaccine Inactivated vaccine Inactivated Vaccines infections International Medical cost Meta-analysis Perspective prevented Probability RCT Real-world evidence Result robust robustness sensitivity analysis the vaccine vaccination Vaccine vaccine efficacy was performed Web of Science website were used [DOI] 10.3389/fpubh.2022.917732 PMC 바로가기 [Article Type] Meta-Analysis
Duration of protection of CoronaVac plus heterologous BNT162b2 booster in the Omicron period in Brazil브라질의 Omicron 기간에 CoronaVac + 이종 BNT162b2 부스터의 보호 기간Article Published on 2022-07-182022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] analysed BNT162b2 booster booster dose Brazil CoronaVac COVID-19 vaccine database death dominance dominant Duration Effectiveness evaluated Heterologous Hospitalization inactivated individual information offered omicron Omicron variant outcome outcomes symptomatic infection tested the SARS-CoV-2 the vaccine vaccinee vaccinees variant [DOI] 10.1038/s41467-022-31839-7 PMC 바로가기 [Article Type] Article