IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines Research Published on 2022-03-252022-10-05 Journal: Nature Immunology [Category] 비임상, [키워드] Activation amplified Anti-inflammatory Cancer COVID-19 Cytokines dependent on Human humans IL-1 IL-1α IL-1β IL-6 immune cells induce Inflammatory response leukocyte Lipid mice murine pathway preclinical studies predicted pro-inflammatory cytokine receptor reduce regulate respond RNA RNA vaccine Signaling systemic inflammation systemic inflammatory response toll-like receptor signaling Toxicity Trigger triggering turn upregulating Vaccine vaccine doses [DOI] 10.1038/s41590-022-01160-y [Article Type] Research
Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update보툴리눔 및 파상풍 신경독소의 독성학 및 약리학: 업데이트Article Published on 2022-03-252024-07-28 Journal: Archives of Toxicology [Category] 파상풍, [키워드] botulism cholinergic Neurotoxins Tetanus therapy Toxicity [DOI] 10.1007/s00204-022-03271-9 PMC 바로가기
Stable Cell Clones Harboring Self-Replicating SARS-CoV-2 RNAs for Drug Screen약물 스크린 용 자체 복제 SARS-COV-2 RNA를 보유하는 안정적인 세포 클론Article Published on 2022-03-232022-08-31 Journal: Journal of Virology [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antiviral antiviral drugs BHK-21 biosafety biosafety level BSL-2 laboratory Cell cell line cell lines cellular clone Compound coronavirus drug drug screen experiment functional Genetic inhibitors of SARS-CoV-2 introduced kidney lack level 2 membrane Mutation non-structural protein nsp1 pair Replication replicon reported reporter reporter gene respiratory robust SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA Screen screened severe acute respiratory syndrome Coronavirus sgmRNA STABLE stable cell stable cell clone. stable cell line stable cell lines the SARS-CoV-2 Toxicity transient expression Viral virus replication [DOI] 10.1128/jvi.02216-21 PMC 바로가기 [Article Type] Article
Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function임상적으로 사용되는 미세소관 표적 약물이 바이러스 감염 및 전달 기능에 미치는 영향Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] analyzed Angiogenesis antiviral activity antivirals biochemical cellular clinically complex compounds correlation crystal structure cytoskeleton DNA and RNA drug drugs Effect function High-resolution higher impact Infection information living cells Mebendazole mebendazole-tubulin complex crystal structure mechanism microtubule microtubule targeting drugs. molecular mechanism movement peptide provided RNA viruses SARS-CoV-2 Structure targeting tested these compound these compounds Toxicity Transport viral infection viral infections viruses [DOI] 10.3390/ijms23073448 PMC 바로가기 [Article Type] Article
Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases Research Published on 2022-03-192022-10-05 Journal: Scientific Reports [Category] 치료제, [키워드] Aede Anophele Chloroquine condition DENV-2 derivative disease Effect effective Efficacy exhibited growth Host IC50 insecticidal lack malaria malarial mice Mosquito P. falciparum Plasmodium falciparum populations purified serotype Spread strain synthesis Toxicity vector vectors viral pathogen virucidal [DOI] 10.1038/s41598-022-08397-5 [Article Type] Research
Environmental and human health risk assessment of mixture of Covid-19 treating pharmaceutical drugs in environmental waters환경 및 인간 건강 위험 환경 해역에서 의약품 치료 약물의 혼합물의 환경 및 인간 건강 위험 평가Article Published on 2022-03-152022-08-31 Journal: The Science of the total environment [Category] MERS, SARS, 신약개발, 치료제, [키워드] acceptable daily intake Algae Analysis Aquatic organisms calculated Chronic toxicity Compound compounds Concentration Consumption COVID-19 COVID-19 pandemic daphnia database drug drugs ecological Ecological risk Effects fish followed by food Health Human Human health effects. Lopinavir Maximum allowable concentration metabolite metabolites mixture organism predicted Quotient responsible ribavirin risk Ritonavir Surface water Toxicity Vulnerable species water waters [DOI] 10.1016/j.scitotenv.2021.152485 PMC 바로가기 [Article Type] Article
A phase 2 trial of avelumab in men with aggressive-variant or neuroendocrine prostate cancer Research Published on 2022-03-152022-10-05 Journal: Prostate cancer and prostatic diseases [Category] 바이오마커, 임상, [키워드] 95% CI Activation Administered anticipated Avelumab Central nervous system Complete conducted COVID-19 COVID-19 pandemic criteria CXCR2 defined disease Efficacy Endpoint enrolled Enrollment histology immune Immune cell Immunotherapy liver median median age men Metastasis monotherapy Msh2 Mutation neuroendocrine open label Patient patients PD-L1 Peripheral blood phase 2 trial Phenotyping poor prognosis positive potential mechanism primary endpoint progression progressive disease Prostate cancer Radiographic Result Safety secondary single center subset survival T-cell Response tested therapy Toxicity Treatment while [DOI] 10.1038/s41391-022-00524-7 [Article Type] Research
Safety and Efficacy of Extended Interval Dosing for Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer During the COVID-19 PandemicCOVID-19 팬데믹 기간 동안 비소세포폐암에서 면역관문억제제에 대한 연장된 간격 투여의 안전성 및 효능Article Published on 2022-03-012022-09-12 Journal: Clinical lung cancer [Category] MERS, SARS, 진단, [키워드] adverse event Cell Characteristics Checkpoint blockade clinically Cohort comparable consolidation coronavirus COVID-19 COVID-19 pandemic Dose adaptation dose reduction Dosing effective Efficacy Extended Frequency immune Immunotherapy in both groups inhibitor initiated interval lung cancer nivolumab no difference occurred Occurrence Patient Pembrolizumab receiving reduced reduction in resulting Retrospective analysis Safe Safety stage III Standard dose survival therapy Toxicity Treatment were assessed [DOI] 10.1016/j.cllc.2021.12.005 PMC 바로가기 [Article Type] Article
Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 아유르베다 전통 약용 식물의 항바이러스 활성Article Published on 2022-03-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] ACE2 ACE2 receptor amarogentin Analysis angiotensin Antiviral antiviral activity antiviral role apoptotic pathway approach attachment inhibitor Ayurveda belladonnine COVID-19 criteria demonstrated disease drug design drug-likeness drug-target interaction Drug-target interactions Efficacy etiological agent G-protein gene network gene network analysis highest affinity Host membrane protein MOST Necrosis network analysis nuclear parameter pathway Pathways pharmacokinetic pharmacokinetics Phosphorylation plant positive potential therapy predicted Protein protein kinase Protein kinase B receptor Regulation responsible SARS-CoV-2 SARS-COV-2 infection secretion Serine Signaling spike glycoprotein Structure-based drug design suggested target target prediction. Toxicity Transport Tumor tumor necrosis tumor necrosis factor Vaccine was performed [DOI] 10.1080/07391102.2020.1832577 PMC 바로가기 [Article Type] Article
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M pro inhibitor in animal models동물 모델에서 경구용 SARS-CoV-2 M pro 억제제인 니르마트렐비르(PF-07321332)의 생식 및 발달 안전성Article Published on 2022-03-012022-09-11 Journal: Reproductive toxicology (Elmsford, N.Y.) [Category] 치료제, [키워드] administration age animal model Antiviral Clinical studies clinical study clinically coronavirus COVID-19 Critical death developmental during pregnancy Effect Embryo Embryo-Fetal development embryonic embryonic development enhancer evaluated Factor female female fertility Fertility Genetic Genetic toxicity high risk Hospitalization hospitalized patient ICH in viral infected with SARS-CoV-2 information inhibitor lack limit dose M pro male mammalian cells manifestation Nirmatrelvir NMV no effect no effects oral Oral COVID-19 therapy patient population Paxlovid PF-07321332 pharmacokinetic phase Pregnancy Prevent progression protease Protein rabbit RAT Rat. RATs Replication reported reproductive risk Ritonavir SARS-CoV-2 SARS-CoV-2 main protease selective severe disease shown specific protein the SARS-CoV-2 therapeutic option therapeutic target therapy Toxicity viral replication virus [DOI] 10.1016/j.reprotox.2022.01.006 PMC 바로가기 [Article Type] Article