transcriptomics – Page 15 – Communicable Diseases Research

Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

추가: 전사체학 및 단백질체학은 말라리아 기생충 스포로조이트의 성숙 과정에서 두 가지 번역 억제 파동을 밝혀냅니다.

Article

Published on 2022-01-062024-08-08
Journal: Nature Communications [Category] 말라리아,

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway

칸디다 알비 칸스 CDK8- 의존적 포스 포 단백체는 FLO8- 의존적 경로를 통한 균사 성장의 억압을 나타낸다.

Research Article

Published on 2022-01-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] acquisition activities Affect Amino acid amino acids analyses ATP Candida Candida albican Candida albicans Cdk8 cell interactions cellular conditions dead dependent on drug resistance functional growth hypha hyphal identify Immune cell Impact inactivation increased expression inhibited Interaction interactions involved leads mediator Mediator complex medium member metabolism modulate Morphological morphological changes morphology mutant Mutation nutrient pathway performed phenotype Phenotypes phosphoproteome phosphorylation site physiological promoted Protein Protein phosphorylation sites Rapid reduced regulate Regulation regulator replaced reveal Serine shown Steady state strain substrate target targets the strongest These data threonine Transcription transcription factor transcriptional transcriptomics variant virulence was used
[DOI] 10.1371/journal.pgen.1009622 PMC 바로가기 [Article Type] Research Article

Multiomics integration-based molecular characterizations of COVID-19

COVID-19의 다중 유학 통합 기반 분자 특성

Review

Published on 2022-01-022022-09-01
Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused complex Consequences contributing to coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diagnostics disease pathogenesis Genetic variation Genomics Health help Host immune immunomics include inflammatory phenotype insight integration knowledge mechanism metabolomics molecular molecular characteristics multiomics multiomics integration offer outcome pandemic Pathogenesis pathogenesis of SARS-CoV-2 proteomics puzzle respiratory responses risk stratification SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity single-cell omics Systems biology target targets therapeutic traits transcriptomics unique Vaccine development virulence virus
[DOI] 10.1093/bib/bbab485 PMC 바로가기 [Article Type] Review

Exploring COVID-19 pathogenesis on command-line: A bioinformatics pipeline for handling and integrating omics data

명령줄에서 COVID-19 발병 기전 탐색: omics 데이터를 처리하고 통합하기 위한 생물정보학 파이프라인

Article

Published on 2022-01-012022-09-11
Journal: Advances in protein chemistry and structural biolo [Category] SARS, 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Bioconductor bioinformatics cholesterol cholesterol metabolism cohort of patients comprehensive view coronavirus COVID-19 COVID-19 pathogenesis Data integration Differentially expressed genes ECM experiment global public health handling healthy highly pathogenic immune system activity infected individuals infected patients information knowledge leukocyte lung mapped marker mechanism metabolism molecules offer Open Access pathway Pathways plasma proteasomal degradation Protein Proteins proteome proteomics Quantitative raw data regulated robust robustness SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 transcript Transcriptome transcriptomics transcriptomics data transcripts virus Wuhan Wuhan, China
[DOI] 10.1016/bs.apcsb.2022.04.002 PMC 바로가기 [Article Type] Article

Single-cell immunology of SARS-CoV-2 infection

SARS-CoV-2 감염의 단세포 면역학

Review

Published on 2022-01-012022-09-11
Journal: Nature biotechnology [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, 임상, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 pathogenesis Cytometry dataset disease severity facilitation Factor flow cytometry heterogeneity Immune cell immune response immune responses Immunity immunological immunology individual cell individual cells meta-analyses Meta-analysis molecular molecular mechanism molecular mechanisms offer pathway portal Protective reported respiratory SARS-COV-2 infection Sequencing severe acute respiratory syndrome Coronavirus single-cell Single-cell transcriptomics subset Therapeutics transcriptomics treatments for COVID-19 Vaccine with COVID-19
[DOI] 10.1038/s41587-021-01131-y PMC 바로가기 [Article Type] Review

SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics

Article

Published on 2022-01-012022-10-30
Journal: iScience [Category] COVID-19,

[키워드] Abstract Alter ATP synthase autophagy cardiovascular cardiovascular medicine cause Cell cell death cellular cellular damage complex component conducted coronavirus coronavirus disease COVID-19 Cycling cyclosporin cyclosporin A Disease progression disrupt domain Endoplasmic reticulum ENhance exacerbate lack mitochondrial Mitochondrial function molecular basis NSP6 ORF10 organelle PBMCs promote Protein Quality control quality-control Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 viral significant changes in suppress suppressed transcript transcriptomic analysis transcriptomics Treatment viability Virology
[DOI] 10.1016/j.isci.2021.103722 PMC 바로가기 [Article Type] Article

Integration of whole genome sequencing and transcriptomics reveals a complex picture of the reestablishment of insecticide resistance in the major malaria vector Anopheles coluzzii

전체 게놈 시퀀싱 및 전 사체의 통합은 주요 말라리아 벡터 Anopheles coluzzii에서 살충제 저항성의 재건에 대한 복잡한 그림을 보여줍니다.

Research Article

Published on 2021-12-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

[키워드] alteration Anophele approach block change changes in colony complex complexity determine diagnostic Diagnostic markers elevated expression of gene Genetic genetic background Genome genomic genomic change increase in increased respiratory rate increasingly insecticide integration inversion Laboratory malaria malaria control malaria vector marker mechanism metabolism microbial Microbiome original oxidative phosphorylation pathway phenotype Population Pyrethroids respiratory rate reveal RNAseq Sequencing subject subset susceptible Transcriptome transcriptomic transcriptomics translated whole genome Whole genome sequencing
[DOI] 10.1371/journal.pgen.1009970 PMC 바로가기 [Article Type] Research Article

Local and systemic responses to SARS-CoV-2 infection in children and adults

소아 및 성인의 SARS-CoV-2 감염에 대한 국소 및 전신 반응

Comparative Study

Published on 2021-12-222022-09-12
Journal: Nature [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법,

[키워드] Adults age airway airways analysed Blood Blood samples Cell characterized children COVID-19 Cytotoxic T cell Cytotoxic T cells dendritic cell dendritic cells Depletion Disease progression early infection epithelial epithelial cell Evidence explain healthy healthy control identify immune cells Increases increases in individual individuals Infection interferon interferon response lymphocyte mechanism nasal Natural killer cells paediatric patients patients with COVID-19 populations reduced response restrict viral replication RNA sequencing SARS-CoV-2 SARS-COV-2 infection significantly increased single-cell subpopulation syndrome T cells tracheal transcriptomics viral replication with COVID-19
[DOI] 10.1038/s41586-021-04345-x PMC 바로가기 [Article Type] Comparative Study

GraphOmics: an interactive platform to explore and integrate multi-omics data

Software

Published on 2021-12-182022-10-27
Journal: BMC Bioinformatics [Category] Coronavirus, Fulltext,

GraphOmics: an interactive platform to explore and integrate multi-omics data

그래픽학 : 다중 생물 데이터를 탐색하고 통합하는 대화식 플랫폼

Software

Published on 2021-12-182022-09-10
Journal: BMC Bioinformatics [Category] 유전자 메커니즘,