Demographic and clinical characteristics associated with variations in antibody response to BNT162b2 COVID-19 vaccination among healthcare workers at an academic medical centre: a longitudinal cohort analysis대학병원 의료진의 BNT162b2 COVID-19 예방접종에 대한 항체 반응의 변화와 관련된 인구통계학적 및 임상적 특성: 종단 코호트 분석Article Published on 2022-05-242022-09-12 Journal: BMJ Open [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence Adults age Analysis anti-spike protein IgG antibody Antibody Response association average blood sample BNT162b2 Characteristics Clinical characteristics clinical factor clinical history cohort analysis Complete Course COVID-19 COVID-19 vaccination demographic determinant Diseases exhibited Factor female healthcare worker hypertension Immunity include inclusion criteria individual infected individual Infection Infectious diseases initial Linear model longitudinal cohort study Male sex mRNA vaccination multisite natural infection of BNT162b2 offer positive postvaccination R 2 remained responses SARS-COV-2 infection Sex significantly sustained USA vaccination Variation while [DOI] 10.1136/bmjopen-2021-059994 PMC 바로가기 [Article Type] Article
Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infectionSARS-CoV-2 감염과 관련된 유전자의 유전적 변이 및 임상 표현형과의 연관성에 대한 자연 선택의 영향Article Published on 2022-05-242022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] 1000 Genomes Project ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive African African diversity Amino acid amino acid change analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antigen association caused clinical phenotype clinical phenotypes complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 Electronic health record Electronic health records enzyme European Genetic genetic diversity genetic variants Genetic variation Genome genomic Haplotype haplotypes Health host gene host genes Human identify Impact in some individual investigated involved Lineage locus LY6E lymphocyte minor allele frequency natural selection nonsynonymous variant pandemic patients with COVID-19 phenotype phenotype association. populations Positive selection protease Protein provide regulatory region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2/COVID-19 Serine serine 2 severe acute respiratory syndrome Coronavirus target targets TMPRSS2 transmembrane transmembrane protease serine 2 variant Variation viral infections viruses [DOI] 10.1073/pnas.2123000119 PMC 바로가기 [Article Type] Article
Pancreatic surgery during the COVID-19 pandemic 2020-2021: an observational cohort study from a third level referral centerObservational Study Published on 2022-05-212022-10-04 Journal: BMC Surgery [Category] 임상, [키워드] Characteristics Clinical outcome Complication country COVID COVID-19 pandemic Elective surgery evaluated fluctuation lockdown Lockdown effect median Mortality not different not significantly different Observational cohort study outbreak pancreatic Pancreatic surgery pandemic Patient periampullary significantly Tumours Variation Volume Waiting time. [DOI] 10.1186/s12893-022-01651-7 PMC 바로가기 [Article Type] Observational Study
Effects of trust, risk perception, and health behavior on COVID-19 disease burden: Evidence from a multi-state US surveyCOVID-19 질병 부담에 대한 신뢰, 위험 인식 및 건강 행동의 영향: 여러 주 미국 설문 조사의 증거Article Published on 2022-05-202022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] Affect behavioral change cognitive Community concerning COVID-19 COVID-19 disease detect disease Effect Effectiveness Effects Government Health healthcare include Increasing Intention Intervention NPI NPIs pandemic population density populations positive Prevent Protective protective effect public health reduced Risk perception rurality significantly social distancing spread of COVID-19 the United State Therapeutic treatment Trust United States Vaccine variable Variation Vermont while [DOI] 10.1371/journal.pone.0268302 PMC 바로가기 [Article Type] Article
Proof of concept for multiplex amplicon sequencing for mutation identification using the MinION nanopore sequencer Research Published on 2022-05-202022-10-05 Journal: Scientific Reports [Category] 변종, [키워드] affected aligning Amplicon Amplicon sequencing approach Coverage described diagnostics DNA equimolar Exome expected FIVE GC content genetic loci Genetic variant genomic region genotyping Illumina independent individual individuals Laboratory less loci methodology minimap2 multiplex Mutation Nanopore nucleotide Oxford PCR amplicon PCR amplicons produced proof of concept Rapid required resolved Sanger sequencing sequence Sequencing target region variant Variation [DOI] 10.1038/s41598-022-12613-7 [Article Type] Research
A randomized controlled trial of a video intervention shows evidence of increasing COVID-19 vaccination intentionRandomized Controlled Trial Published on 2022-05-192022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] Affect change childhood conducted control group COVID-19 mRNA vaccine COVID-19 vaccination COVID-19 vaccine Effect Evidence expressed expressing female group had more imperative Increasing information Intention Intervention male overcome parental participant public health Randomized controlled trial receiving Research respond shown statistically significant threshold transcript vaccination Vaccine hesitancy Variation video intervention YouTube [DOI] 10.1371/journal.pone.0267580 PMC 바로가기 [Article Type] Randomized Controlled Trial
INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes새로 진단된 제1형 당뇨병을 가진 소아, 청소년 및 성인을 대상으로 한 임상시험 의약품 평가를 위한 INNODIA 마스터 프로토콜Article Published on 2022-05-182022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 바이오마커, [키워드] adaptive adolescents and adult backbone baseline benefit Beta-cell function Biomarker Biomarkers C-peptide children Clinical data clinical sample clinical samples clinical trials Combination combination therapies comparable control group Decline demonstrated determine diabete diabetes diagnosed dosage Efficacy Efficacy and safety Endpoint evaluate greater identification identify IMPROVE include individual investigational medicinal product lack Master protocol mechanistic data natural history participant phase Phase 2 phase 2 clinical trials phase 2 studies Phase 2 study phase 3 study Prevent prevention product provide response robust sample size calculation Stratification subsequent trials Type 1 diabetes Variation [DOI] 10.1186/s13063-022-06259-z PMC 바로가기 [Article Type] Article
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functionsmRNA-1273 및 BNT162b2 COVID-19 백신은 Fc 매개 효과기 기능에 차이가 있는 항체를 유도합니다Article Published on 2022-05-182022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody approved binding BNT162b2 cell activation Cohort Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Efficacy elicit epitope evade Fc-mediated effector function function functional functional capacity Hospital staff humoral immune response humoral immune responses IgA immune response immune responses Killer cell morbidity morbidity and mortality mRNA mRNA vaccines mRNA-1273 mRNA-1273 vaccine mRNA-1273 vaccines N-terminal N-terminal domain natural killer natural killer cell neutralization Neutralizing antibodies neutrophil phagocytosis potential differences protective immunity RBD Receptor binding domain recipient recipients reduced Region respiratory responses robust SARS-CoV-2 the vaccine the vaccines These data Vaccine Vaccines variants variants of concern Variation Viral viral variant Viral variants wake wild-type [DOI] 10.1126/scitranslmed.abm2311 PMC 바로가기 [Article Type] Article
Predefined and data driven CT densitometric features predict critical illness and hospital length of stay in COVID-19 patients Research Published on 2022-05-172022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료법, [키워드] 95% CI Accuracy age Analysis analyzed C-index Clinical data Cohort competing component Contrast COVID-19 patient COVID-19 patients COVID-GRAM Critical Critically ill CT chest death feature Features highest hospital incidence logistic regression model LOS lung Lung CT multivariate NLR outcome predict Predictive predictor principal Ratio Regression model risk ROC analysis severity significant effect Standard survival the patient Variation was used were assessed [DOI] 10.1038/s41598-022-12311-4 [Article Type] Research
Health-Promoting Quality of Life at Work during the COVID-19 Pandemic: A 12-Month Longitudinal Study on the Work-Related Sense of Coherence in Acute Care Healthcare ProfessionalsObservational Study Published on 2022-05-162022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] acute care Anxiety association average Care Coherence COVID-19 COVID-19 pandemic decrease Deterioration enrolled Evolution examined healthcare Healthcare professional healthcare professionals Healthcare workers investigated life Linear model longitudinal Mental mental health pandemic professional Psychological psychological health psychological symptom Quality reported resulting sense Stage Symptom trauma Variation work work-related sense of coherence. [DOI] 10.3390/ijerph19106053 PMC 바로가기 [Article Type] Observational Study