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[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AP, affinity-purification arginine arginine methylation assembly binding blocked cancer treatment Cell culture clinical trial clinical trials component condensate coronavirus CTD, C-terminal dimerization domain defined DMSO, dimethylsulfoxide dose-dependent manner drugs FBS, fetal bovine serum Flag-N, Flag-epitope N protein G3BP1 genomic RNA GSK-3, glycogen synthase kinase 3 HEK293 cells hnRNPA1, heterogeneous nuclear ribonucleoprotein A1 host antiviral response host protein inhibited inhibiting inhibitor inhibitors Interaction life cycle lysine MERS-CoV, Middle East respiratory syndrome coronavirus methylarginine methylated Methylation methyltransferase motifs N protein N, nucleocapsid NTD, N-terminal RNA-binding domain nucleocapsid (N) protein nucleocapsid protein PAR-CLIP, photoactivatable ribonucleoside–enhanced crosslinking and immunoprecipitation PFA, paraformaldehyde PRMT1 PRMTs, protein arginine methyltransferases property Protein protein 3 RBP, RNA binding protein reduced regulate regulated required residue residues respiratory RGG/RG motif RIP, RNA immunoprecipitation RNA RNA binding S, spike SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 replication SARS-CoV-2 virion SARS-CoV-2 virions SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 sequences severe acute respiratory syndrome Coronavirus SGs, stress granules significantly SMN, survival of motor neuron SR, serine/arginine-rich SRPK, SRSF protein kinase Stage Stress stress granule stress granules Substitution substrates suppress TDRD3, Tudor domain-containing protein 3 the N protein therapeutic Treatment Type type I type I PRMT inhibitor VeroE6 cell VeroE6 cells Viral viral genome viral life cycle Viral protein Viral proteins viral replication virion virions vRNP, viral ribonucleoprotein
[DOI] 10.1016/j.jbc.2021.100821 PMC 바로가기 [Article Type] Research Article