Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization [DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article
Thoracıc surgery experience from the largest pandemic hospital in Europe유럽 최대 유행성 병원의 흉부 수술 경험Article Published on 2022-06-012022-09-11 Journal: Irish Journal of Medical Science [Category] COVID19(2023년), SARS, 치료기술, [키워드] adaptation addition age average Contact contact with coronavirus disease country COVID-19 COVID-19 disease COVID-19 pandemic died direct contact disease Europe evaluated experience Health Organization health problem Healthcare professional healthcare professionals highest hospital insufficiency Lungs measure men morbidity rate multiorgan failure not seen occur oncology patients pandemic Pandemics Patient patient age PCR test PCR tests performed postoperative postoperative period Preoperative period public health required risk SARS-CoV-2 coronavirus surgery surgical Thoracic Thoracic Surgery Treatment Turkey women World Health Organization [DOI] 10.1007/s11845-021-02722-z PMC 바로가기 [Article Type] Article
Influence of exercise and vitamin D on the immune system against Covid-19: an integrative review of current literatureCovid-19에 대한 면역 체계에 대한 운동과 비타민 D의 영향: 현재 문헌의 통합 검토Review Published on 2022-06-012022-09-11 Journal: Molecular and cellular biochemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus addition affected age anti-inflammatory cytokine anti-inflammatory cytokines association caused chronic disease Chronic diseases Concentration contribute coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm Cytokines Defense defense mechanism environmental factors Factor genetics Health Organization health system Hypovitaminosis D IL-10 IL-1β IL-4 IL-6 immune response immune system increase in Infection infections Infectious disease Infectious diseases influence maintenance mechanism microorganisms morbidity morbidity and mortality New coronavirus nutritional status pandemic Patient physical physical activity Physical exercise Physical status pro-inflammatory cytokine pro-inflammatory cytokines reduction in Regular respiratory respiratory infections responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly the cytokine storm the disease therapy TNF-α triggering viral infections virus Vitamin D vitamin D level vitamin D levels WHO World Health Organization [DOI] 10.1007/s11010-022-04402-7 PMC 바로가기 [Article Type] Review
The emergence and epidemic characteristics of the highly mutated SARS-CoV-2 Omicron variant고도로 돌연변이된 SARS-CoV-2 오미크론 변종의 출현 및 전염병 특성Review Published on 2022-06-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] accumulated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Amino acid B.1.1.529 Beta Characteristics coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 defined Delta delta variant dominant Epidemic Gamma Genome group Health Organization Immune escape information mutated Mutation mutations omicron Omicron variant reactivity reported SARS-CoV-2 SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus shown Spike protein strain the epidemic the spike protein the WHO type strain Vaccine Vaccine development variant VoC VOCs WHO wild-type strain World Health Organization [DOI] 10.1002/jmv.27643 PMC 바로가기 [Article Type] Review
Game of transmissions (GoT) of SARS-CoV-2: Second wave of COVID-19 is here in IndiaReview article Published on 2022-06-012022-10-05 Journal: Current Opinion in Environmental Science & Health [Category] 변종, [키워드] Airborne transmission caused concerning Corona virus coronavirus 2 COVID-19 disease game globe India infectious agent information investigated knowledge MOST organization pandemic pathway Precision provided Rapid respiratory SARS-CoV-2 SARS-CoV-2 transmission second second wave selective Spread temporal variation trajectory Transmission transmission pathway transmissions virus WBE while WHO World Health Organization Worldwide WWTPs [DOI] 10.1016/j.coesh.2022.100355 [Article Type] Review article
Structure-based virtual screening, in silico docking, ADME properties prediction and molecular dynamics studies for the identification of potential inhibitors against SARS-CoV-2 M proSARS-CoV-2 M pro에 대한 잠재적 억제제 식별을 위한 구조 기반 가상 스크리닝, 인실리코 도킹, ADME 특성 예측 및 분자 역학 연구Article Published on 2022-06-012022-09-11 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] ADME affected Amino acid amino acid residue Asinex library ASN binding CADD carried caused complex Compound compounds computer Computer aided drug design conformational contagious COVID-19 COVID-19 patients docked docking drug drug candidate drug design druggability enzyme evaluated GLU Health Organization hydrogen Hydrogen bond hydrogen bond interactions identify in silico include Infection inhibitor interactions knocking down Ligand M pro maturation molecular molecular dynamics Molecular dynamics simulation Mortality Mpro protein Mutation optimization pandemic participated pharmacological PHE Protein protein-ligand protein-ligand interaction protein-ligand interactions Replication responsible RMSD RMSF SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 Mpro SARS-CoV-2 Mpro protein Schrodinger software stability strain therapeutic option these compound these compounds TRP Virtual screening virulent was used World Health Organization [DOI] 10.1007/s11030-021-10298-0 PMC 바로가기 [Article Type] Article
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19Research article Published on 2022-05-142022-10-05 Journal: EClinicalMedicine [Category] 진단, 치료기술, [키워드] adaptive Adaptive immune response analyzed Antigen association Berlin cell counts cell types characterized clinical Clinical course Clinical management clone controls coronavirus coronavirus disease COVID-19 COVID-19 disease severity Critical cross-sectional decrease Disease progression disease severity distribution enrichment examined figure finding funding group healthy healthy control healthy subject heavy chain highest highlighting HLA immune Immune receptor Immune repertoires immune response Immunoglobulin IMPROVE increase in leukocyte lymphocyte measure Metadata Mild outbreak Peripheral blood Predictive Probability progression receptor SARS-CoV-2 scale sequence Sequencing severe COVID-19 severe COVID-19 disease severity subject subjects T cell T cell receptor T cells target the disease Therapies TRB TRD understanding variable with COVID-19 World Health Organization [DOI] 10.1016/j.eclinm.2022.101438 [Article Type] Research article
BeCaked: An Explainable Artificial Intelligence Model for COVID-19 Forecasting Research Published on 2022-05-132022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] analyzed artificial autoencoder average mortality can be used center China Combination compartmental model consequence country COVID-19 deep effective Engineering FIVE Forecasting high accuracy intelligence Johns Hopkins University learning Model occurred offer overcome pandemic Pandemics parameter provided reported Science Spread System weakness World Health Organization Wuhan [DOI] 10.1038/s41598-022-11693-9 [Article Type] Research
Establishing a framework towards monitoring HCV microelimination among men who have sex with men living with HIV in Germany: A modeling analysis독일에서 HIV에 감염된 남성과 성관계를 가진 남성의 HCV 미세 제거 모니터링을 위한 프레임워크 구축: 모델링 분석Article Published on 2022-05-122022-09-11 Journal: PLoS ONE [Category] 치료제, [키워드] Analysis COVID-19 pandemic diagnosed direct-acting antiviral Direct-acting antivirals early treatment effort Establishing evaluate expected Germany greater HCV Health Organization hepatitis C hepatitis C virus HIV HIV infection Impact incidence increase in Infection men Prevalence Prospective reducing reduction risk risk reduction Sex track Transmission model treat Treatment WHO with HIV World Health Organization [DOI] 10.1371/journal.pone.0267853 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron (B.1.1.529) Variant: No Time to Wait!SARS-CoV-2 오미크론(B.1.1.529) 변형: 기다릴 시간이 없습니다!Article Published on 2022-05-112022-09-11 Journal: Acta bio-medica : Atenei Parmensis [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect B.1.1.529 coronavirus coronavirus disease Coronavirus disease 2019 disease Health Organization help Immunity International Mutation NEWS omicron outbreak pandemic raised SARS-CoV-2 Spread spreading the disease time variant VoC WHO World Health Organization [DOI] 10.23750/abm.v93i2.12712 PMC 바로가기 [Article Type] Article