functional
[용어속성] Term
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections
Research Article
[키워드] adaptive
Adaptive immunity
Administered
Blood
canonical
COVID-19
COVID-19 infection
COVID-19 infections
COVID-19 patient
COVID-19 patients
Critically ill
cytokine
Cytokine storm
diagnostic
dissemination
Elevation
ELISPOT
evaluate
Ex vivo
functional
healthy control
Host
host immunity
host response
Hyperinflammatory
hypothese
Hypothesis
IL-6 level
IL-7
immune effector cell
immune function
immunoassay
Immunosuppression
immunosuppressive
innate immune
Innate immunity
lack
less
monocyte
mononuclear cell
morbidity and mortality
organ injury
pathologic
Patient
patients
patients with COVID-19
produced
proinflammatory cytokines
protective immunity
reduced
restored
Sepsis
stimulated
Support
suppresse
T cell
T cell subset
Therapies
TNF-α
Volunteer
[DOI] 10.1172/jci.insight.140329 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1172/jci.insight.140329 PMC 바로가기 [Article Type] Research Article
Opioid and neuroHIV Comorbidity – Current and Future Perspectives
아편유사제 및 neuroHIV 동반 질환 – 현재 및 미래 전망
Review
Published on
Journal: Journal of neuroimmune pharmacology : the official [Category] MERS, 변종, 유전자 메커니즘,
Journal: Journal of neuroimmune pharmacology : the official [Category] MERS, 변종, 유전자 메커니즘,
[키워드] μ-Opioid receptor (OPRM1 )
Antiretroviral therapy
Astrocyte
blood-brain barrier
Brain
breakdown
Buprenorphine
C-C motif chemokine receptor 5 (CCR5)
cellular
Central nervous system
chemokine
Clinical studies
clinical study
CNS
Comorbidity
Compound
consequence
COVID-19
Critical
current
Cytochrome P450 3A4 (CYP 3A4)
disease
disorder
drugs
Endogenous opioid system of peptides and receptors
experimental models
expression
focus
functional
Functional selectivity/biased agonism
Future
gene product
genetic variants
hand
HIV
HIV-1
HIV-associated neurocognitive disorders
Host
Human immunodeficiency virus
immunodeficiency virus
include
increase
Interaction
key consideration
key considerations
Maladaptive neuroplasticity
mechanism
Methadone
methodology
microglia
molecular
National
neuroHIV
Neurovascular
not seen
Oligodendroglia
opiate
opioid
opioids
P-glycoprotein
Pathogenesis
pathophysiologic
pathophysiology
penetration
Pro-brain-derived neurotrophic factor (pro-BDNF)
Prognosis
progression
Protein
question
recent
receptor
severity
Synaptodendritic degeneration
tight junction
unique
variants
with HIV
[DOI] 10.1007/s11481-020-09941-8 PMC 바로가기 [Article Type] Review
[DOI] 10.1007/s11481-020-09941-8 PMC 바로가기 [Article Type] Review
Evolution of Early SARS-CoV-2 and Cross-Coronavirus Immunity
Research Article
[키워드] acute respiratory syndrome
Antibody Response
asymptomatic infection
binding
caused
changes in
Cohort
coronavirus
correlation
CoV
CoVs
Critical
cross-reactivity
detect
determine
develop
diagnose
diagnostic
diagnostics
disease
disease manifestation
Evidence
Evolution
Evolution of SARS-CoV-2
example
explain
Fc-receptor binding
functional
heterogeneity
Heterologous
HKU1
humoral immune response
Humoral immunity
hypothese
immune response
Immunity
in viral
individual
Infection
Influenza
involved
management
Mild
NL63
Novel coronavirus
other coronavirus
outcome
prevalent
RBDs
Receptor binding
Receptor binding domain
respiratory infection
respiratory infections
Respiratory pathogens
respiratory syncytial virus
respiratory viruses
response
responses
SARS-coronavirus
SARS-CoV-2
severe disease
Spread
Symptom
targets
the SARS-CoV-2
Vaccine development
Vaccine-induced immunity
viral infection
viruses
[DOI] 10.1128/mSphere.00622-20 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/mSphere.00622-20 PMC 바로가기 [Article Type] Research Article
Biosynthesis of medicinal tropane alkaloids in yeast
Research
[키워드] amino acids
Bacteria
Biosynthesis
challenge
COVID-19
derivative
disorder
enzyme
event
facilitate
functional
functional expression
Heterologous
identify
IMPROVE
inhibitor
Medicine
Medicines
Neurological disease
pathway
plant
plants
platform
Protein
robust
scaled
sugar
therapeutic agent
titres
Tropane
tropane alkaloid
yeast
[DOI] 10.1038/s41586-020-2650-9 [Article Type] Research
[DOI] 10.1038/s41586-020-2650-9 [Article Type] Research
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors †
Chemistry
[키워드] acting
clinically
compounds
conserved
coronavirus
cysteine
cysteine protease
domain
drug resistance
drug target
Ebselen
FIVE
functional
Helicase
identify
in viral
inhibit
inhibit SARS-CoV-2
nsp13
outbreak
pandemic
physical
predicted
protease
Protein
Proteins
reduce
Replication
Safe
SARS-CoV-2
Stage
transcription factor
Treatment
Virus life cycle
virus replication
[DOI] 10.1039/d0sc02646h PMC 바로가기 [Article Type] Chemistry
[DOI] 10.1039/d0sc02646h PMC 바로가기 [Article Type] Chemistry
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition
Research
[키워드] common cold Coronaviruses
convalescent
convalescent individuals
COVID-19
diagnostic
Diversity
dominant
Evidence
facilitate
functional
Heterologous
HLA class I
HLA-DR
identify
Immunity
individual
individuals
measure
Mild symptom
multiple epitopes
peptide
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 peptide
SARS-CoV-2-specific peptide
seronegative
similarity
T cell
T cell epitope
T cell response
therapeutic
Vaccines
viral infections
[DOI] 10.1038/s41590-020-00808-x [Article Type] Research
[DOI] 10.1038/s41590-020-00808-x [Article Type] Research
Genomic diversity and evolution, diagnosis, prevention, and therapeutics of the pandemic COVID-19 disease
Genomics
[키워드] acquisition
acute respiratory syndrome
Amino acid
Analysis
annotation
Antigen
available data
candidate
candidate drugs
caused
cleavage site
Comprehensive
coronavirus
coronavirus disease
COVID-19
COVID-19 disease
COVID-19 patients
Deletion
diagnose
Diagnosis
diagnostic
diagnostics
effective
Evolution
functional
furin
genetic diversity
Genome evolution
genomic
glycoprotein
insertion
knowledge
Laboratory
management
mutations
nucleotides
pandemic
pathogenic
polybasic
predicted
real-time RT-PCR
released
Research
RNA virus
SARS-CoV-2
SARS-CoV-2 genome
shown
Substitution
Surveillance
therapeutic
therapeutic agent
Therapeutics
therapy
Trial
trials
Vaccine
Vaccines
viral infection
virus
whole-genome
Wuhan, China
zoonotic
[DOI] 10.7717/peerj.9689 PMC 바로가기 [Article Type] Genomics
[DOI] 10.7717/peerj.9689 PMC 바로가기 [Article Type] Genomics
Computational and Transcriptome Analyses Revealed Preferential Induction of Chemotaxis and Lipid Synthesis by SARS-CoV-2
Article
[키워드] Activation
acute respiratory syndrome
Analysis
analyzed
bioinformatics
Calu-3
category
change
characterized
chemotaxis
coding
commonality
Comprehensive
coronavirus
COVID-19
Defense
epithelial cell
explain
fatty
fatty acid synthesis
FIVE
functional
gene expressions
hallmark
host cell
human lung
Hyperactivation
IFN response
IL1A
Immune cell
immune response
induction
Inflammatory
Inflammatory cytokine storm
influenza A
influenza B
Ingenuity
interferon
Lipid
mechanism
Middle East
mock-infected cell
noncoding RNA
pathway
Pathway analysis
respiratory
Revealed
rhinovirus
RNA-Seq
SARS-CoV
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2-infected cells
SARS-MERS
Severe case
signaling pathway
Spread
synthesis
TLR7
TNF
transcriptional
Transcriptome
viral infection
viral strain
virus
viruses
[DOI] 10.3390/biology9090260 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/biology9090260 PMC 바로가기 [Article Type] Article
Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2
Review
[키워드] absence
ACE2
ACE2 receptor
acute respiratory syndrome
affected
Angiotensin-converting enzyme
angiotensin-converting enzyme 2
antiviral activity
bind
blood pressure
caused
coronavirus
country
CoV
COVID-19
Critical
death
drug
Efficacy
effort
epithelial cell
flavonoid
functional
Host
host cells
in vitro
increase in
infect
inhibition activity
Medicine
morbidity
Mortality
natural
Novel coronavirus
outbreak
over
pandemic
Potential
potential therapeutic target
previous study
public health threat
receptor
Regulation
SARS-CoV-2
the spike protein
these compound
virus
with COVID-19
[DOI] 10.3390/molecules25173980 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/molecules25173980 PMC 바로가기 [Article Type] Review