Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses전사체 메타 분석에 의해 발견된 중추신경계 장애와 암 사이의 역병환에 대한 분자적 증거Research Article Published on 2014-02-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Alzheimer's disease Alzheimer's disease Analysis Author biological processe biological processes cancers Candidates causes CENTRAL CNS CNS disorder Colorectal Comorbidity complex disorders conditions conducted contribute decrease Degradation deregulated deregulation described disease disorder disorders downregulated downregulation driven by Drug repurposing drug treatment drug treatments epidemiological Evidence expected expression Factors Gene Genetic genetic factors Hypothesis incidence inverse lung mechanism Meta-analysis molecular nervous observé opposite overlap Parkinson's Disease pathway Pathways Patient PIN1 Probability progression promote Prostate protective effect Protein related risk Schizophrenia System tested transcriptomic Treatment understanding upregulated upregulation Wnt [DOI] 10.1371/journal.pgen.1004173 PMC 바로가기 [Article Type] Research Article
The Transcription Factor BcLTF1 Regulates Virulence and Light Responses in the Necrotrophic Plant Pathogen Botrytis cinerea전사 인자 BcLTF1은 괴사성 식물 병원체 Botrytis cinerea에서 독성과 빛 반응을 조절합니다Research Article Published on 2014-01-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulation addition Affect alternative oxidase alternative respiration enzymes antioxidants AOX apothecia applied approach arising Aspergillus nidulan Aspergillus nidulans Author BcLTF1 bctlf1 Botrytis cinerea caused characterized circadian rhythm conditions conidia continuous light Deletion dependent on detoxification detrimental effect detrimental effects dicotyledonous plant differentiation dispersal ecological ecological niche equilibrium Evidence exogenously exposure to expression expression level expression levels expression of gene Factor fertilization filamentous fungi fruiting bodies function fungal fungal pathogen fungi fungus GATA transcription factor Gene gene encoding Genes gray mold disease gray mold diseases growth rate growth rates homoeostasis homologue Host host infection hypersensitivity illumination impair Increased increased expression induce Infection LIGHT macroconidia macromolecule macromolecules majority metabolism Microarray analyses microarray analysis microconidia mitochondrial mitochondrial dysfunction modulated mutant mutants necrotrophic pathogen necrotrophic pathogen Botrytis cinerea Neurospora crassa NsdD Organisms Orientation over-expression overexpression oxidative stress oxygen Pathogens photomorphogenesis photoreceptor phototropism pigments plant plants predicted propagule propagules PROTECT random mutagenesis reactive oxygen species reactive oxygen specy Regulation reproductive required respiration enzymes respond response restoration ROS scavenging sclerotia Secondary metabolism sexual reproduction singlet oxygen spores Structure structures SUB-1 survival TF 1 transcription factor transcriptional level virulence [DOI] 10.1371/journal.pgen.1004040 PMC 바로가기 [Article Type] Research Article
Integrative “Omics”-Approach Discovers Dynamic and Regulatory Features of Bacterial Stress Responses통합 "Omics" 접근 방식으로 세균 스트레스 반응의 동적 및 조절 기능 발견Research Article Published on 2013-06-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (transcriptome adaptation adaptive mechanism adaptive mechanisms addition alternative approach assigned Author Bacteria cellular stress responses change choice complex conditions determine different dynamic Effect elevated temperature event events example exhibited expression expression level expression pattern expressome Factor Factors feature found fraction Frequency Gene Genes Genome help in addition to include initiated integration maintain mass spectrometry Microarrays mRNA mRNA level mRNA levels mRNAs Occurrence open reading frames operon organism oxygen phototrophic polar polysome Population post-transcriptional level Protein Proteins proteome provided quantification quorum regulated Regulation Regulatory reported required response RNA-Seq RpoE singlet oxygen Stress stress condition stress conditions stress response stress responses survival transcriptional activation transcriptional level transcriptional regulator transcriptional regulators Transcriptome translation translational was used [DOI] 10.1371/journal.pgen.1003576 PMC 바로가기 [Article Type] Research Article
The [ PSI + ] Prion Exists as a Dynamic Cloud of Variants[ PSI + ] Prion은 다양한 변종 클라우드로 존재합니다.Research Article Published on 2013-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles amyloid appear array Author Cell clones cloud conditions conformation different dominant dynamic effective Efficiency Evidence explain expressing growth infectious isolate mitotic growth MOST passage Phenotypes Polymer polymorph prion progeny Protein protein sequence PSI related Saccharomyces cerevisiae segregation sequence Spectrum Spread strain Structure structures subunit Sup35p Support three group three groups translation Transmissibility Transmission transmission efficiency transmission pattern variant variants yeast [DOI] 10.1371/journal.pgen.1003257 PMC 바로가기 [Article Type] Research Article
Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivoArticle Published on 2012-07-202022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] accessory protein accessory proteins acute respiratory syndrome Amino acid Analysis analyzed approach cellular conditions coronavirus Coronaviruses cytoplasm described eight ENCODE experiment Factor functions Genome homology immunoprecipitation in vivo infective Interaction involved LC–MS pathogenicity Protein Protein 6 Protein 9b protein–protein interactions Proteins proteomic Replication SARS Coronavirus SARS-CoV SARS-CoV infected cell SARS-CoV infected cells severe shown structural protein Viral protein virus [DOI] 10.1016/j.virusres.2012.07.012 PMC 바로가기 [Article Type] Article
The Regulatory Network of Natural Competence and Transformation of Vibrio choleraeVibrio cholerae의 자연적 능력 및 변형의 규제 네트워크Research Article Published on 2012-06-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Analysis aquatic bacterium aquatic environment assays Author autoinducers Bacteria Bacterial bacterium CAMP carbon Carbon catabolite repression catabolite repression Cell chitin chitinous chitinous exoskeleton colonization Combination competence condition conditions consequence contribute Degradation degradation products dependent on determine developmental different DNA ecological environmental niche environmental reservoirs Evidence Evolution Express expression pattern Extracellular Factor found Gene Gene Expression gene transfer Genes Genetic genetic transformation genomes growth heterogeneity heterogeneous homogeneous horizontal gene Horizontal gene transfer human pathogen immunological detection initiate intracellular signaling investigated involved lead maintenance majority metabolism mode natural Natural competence natural transformation network organism pathogenic phenotype protein level protein levels quantitative RT–PCR quorum-sensing pathways regions regulated regulatory circuit released reporter fusions required signaling cascade signaling pathway single cell level tested TfoX the cells transcriptional transfer transformation V. cholerae Vibrio cholerae western blot Western blot analysis zooplankton [DOI] 10.1371/journal.pgen.1002778 PMC 바로가기 [Article Type] Research Article
SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatusSREBP는 인간 곰팡이 병원체 Aspergillus fumigatus에서 트리아졸 약물 및 저산소증 반응을 중재하기 위해 철과 에르고스테롤 항상성을 조정합니다Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] A. fumigatus acquisition activated adaptation Adding addition advance Aspergillus fumigatus Author binding Candida albican Candida albicans caused cellular response class clinically condition conditions Coordinate Critical Cryptococcus neoforman Cryptococcus neoformans decrease dependent on drug drug susceptibility drugs ergosterol eukaryotes found foundation fungal fungal infections fungal pathogen Gene Genetic growth growth defect Health Human hypoxia hypoxic identify immunocompromised condition infections initial involved iron iron homeostasis Iron metabolism led to lethal disease majority mechanism metabolism microenvironment Most patients mRNA mutant mutants pathogenic Pathogens Patient phenotype Protein regulate Regulation regulatory element required response restoration Sterol Support susceptibility susceptible These data transcription factor transcription factors triazole virulence [DOI] 10.1371/journal.pgen.1002374 PMC 바로가기 [Article Type] Research Article
Role of Exonic Variation in Chemokine Receptor Genes on AIDS: CCRL2 F167Y Association with Pneumocystis PneumoniaAIDS에 대한 케모카인 수용체 유전자의 외음성 변이의 역할: 폐포자충과의 CCRL2 F167Y 연관성Research Article Published on 2011-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI accelerated addition Affect AIDS Amino acid Analysis association associations Atypical Author CCR2 CCR3 CCR5 CCR8 CCRL2 Cell Chemokine receptor chromosome Cluster cohorts conditions CX3CR1 defined dendritic cell disease Disease progression DNA Effect exonic FIVE functional variant functional variants Gene Genes Genetic genetic association Genetic variation genotyped HIV-1 HIV-1 infection host cells Human immune regulation in addition to indicated Inflammation involved key factor lung majority natural history Non-synonymous outcome Pathogenesis Pneumonia progression role Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs surface protein survival survival analysis tested variant Variation [DOI] 10.1371/journal.pgen.1002328 PMC 바로가기 [Article Type] Research Article
The sialic acid binding activity of the S protein facilitates infection by porcine transmissible gastroenteritis coronavirusResearch Published on 2011-09-122022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Adsorption After analyzed approach avian coronavirus binding binding activity Cell concerning conditions coronavirus coronavirus S protein cultured cell cultured cells deplete determine different facilitate gastroenteritis IBV Infection intestinal Miller mock-treated mutant mutants parental Plaque assay reduction in Result sialic acid sialic acid binding activity strain Strains t-test TGEV the S protein transmissible gastroenteritis virus treated Treatment virion virus was performed was reduced was used [DOI] 10.1186/1743-422X-8-435 PMC 바로가기 [Article Type] Research
Improved microarray gene expression profiling of virus-infected cells after removal of viral RNAMethodology Article Published on 2008-05-142022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Accuracy acquisition alteration analyses conditions coronavirus detect different False-positive Gene Expression Gene expression profiling host cell IMPROVE Improved infected cell Infection interfere investigated mean Microarray microarray analysis Microarrays reduced reliability Result RNA RNAs sensitivity significantly tested total RNA Viral RNA virus-infected cell vRNA [DOI] 10.1186/1471-2164-9-221 PMC 바로가기 [Article Type] Methodology Article