Susceptibility of White-Tailed Deer to Rift Valley Fever VirusArticle Published on 2018-09-012023-05-31 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] arbovirus Epidemiology livestock Odocoileus virginianus Rift Valley fever virus RVFV susceptibility United States viruses white-tailed deer zoonoses [DOI] 10.3201/eid2409.180265 PMC 바로가기
Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation단순 비뇨 생식기 임질 치료를 위한 게포티다신: 2상, 무작위, 용량 범위, 단일 경구 용량 평가Articles and Commentaries Published on 2018-08-152022-09-07 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 1:1 95% confidence interval adverse event adverse events Antibiotics Bacterial baseline clinical collected Culture cure demonstrated dose drug-resistant effective Efficacy and safety enrolled evaluated Gender gepotidacin gonorrhea groups highest infections inhibitor inhibitory concentration isolate isolates microbiologically Mutation Neisseria gonorrhoeae New participant Participants pharyngeal Phase 2 Phase 2 study Randomized receive rectal rectal specimens rectal swab Registration specimen stratified susceptibility Swab therapeutic option Treatment urogenital [DOI] 10.1093/cid/ciy145 PMC 바로가기 [Article Type] Articles and Commentaries
A genome-wide association study identifies a susceptibility locus for biliary atresia on 2p16.1 within the gene EFEMP1게놈 전체의 연관성 연구는 EFEMP1 유전자 내에서 2p16.1의 담도 폐쇄증에 대한 감수성 유전자좌를 확인합니다.Research Article Published on 2018-08-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis Anomaly association Author bile ducts Biliary atresia Cell cell proliferation cell type cell types characterized cholestasis cirrhosis Cohort cohorts Combination complex composed Control controls demonstrated disease disease manifestation Diseases disorder EFEMP1 elevated ENCODE etiology expressed expression Extracellular Extracellular matrix Factor fibroblast fibrosis genetic loci genetic risk factor genetic risk factors Genome Genome wide association study Genome-wide association study genome-wide significant GWAS human liver Hypothesis identify immunohistochemistry implicated increase in independent infectious Inflammatory intron liver liver failure livers locus matched controls mechanism Meta-analysis organogenesis Patient pediatric performed portal Protein responsible RNA expression secreted smooth muscle SNP SNPs specimen susceptibility susceptibility loci transcript two group two groups vascular smooth muscle vascular smooth muscle cells was performed [DOI] 10.1371/journal.pgen.1007532 PMC 바로가기 [Article Type] Research Article
Epigenetics and Malaria Susceptibility/Protection: A Missing Piece of the Puzzle에피제네틱스와 말라리아 취약성/보호: 퍼즐의 잃어버린 조각Review Published on 2018-08-032024-08-11 Journal: Frontiers in immunology [Category] 말라리아, [키워드] Epigenetic Falciparum Immunity malaria protection susceptibility [DOI] 10.3389/fimmu.2018.01733 PMC 바로가기 [Article Type] Review
Genetic ancestry and population differences in levels of inflammatory cytokines in women: Role for evolutionary selection and environmental factors여성의 염증성 사이토카인 수치의 유전적 조상과 집단 차이: 진화적 선택과 환경적 요인의 역할Research Article Published on 2018-06-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated adaptive African age alcohol allele Analysis ancestry Antigen antigen receptor Blood cells CCL11 CCL2 chemokine chemokines chronic inflammation circulating circulating cytokines cytokine Cytokines Diseases Endemic environmental factor eosinophils European examined explain exposure to Factor Factors finding gene encoding Genetic genetic difference genetic differences Genetic variant Genetic variation Health Human human immunity IFNα2 IL10 IL1RA IL4 immune immune response immune response genes immune system Immunity implicated implication individual Infection Inflammation Inflammatory Inflammatory cytokine innate and adaptive immunity involved Level living environment living environments Local malaria Migration molecular monocyte Monocytes obesity occur Part pathogen Pathogens phenotypic variance plasma Plasma levels populations pro-inflammatory Protein receptor protein red blood cells Regulation role Selection selection pressure signal significant difference significant differences smoking susceptibility systemic level thought variant Variation White blood cells women [DOI] 10.1371/journal.pgen.1007368 PMC 바로가기 [Article Type] Research Article
Anti-bacterial and anti-biofilm activity of commercial organic acid products against Salmonella enterica isolates recovered from an egg farm environmentarticle Published on 2018-04-302024-09-01 Journal: Avian Pathology [Category] 살모넬라증, [키워드] Biofilms Concentration food safety organic acid Salmonella susceptibility [Article Type] article
Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus삼투성 항상성의 순환 di-AMP 조절은 B군 연쇄상 구균에서 필수적입니다Research Article Published on 2018-04-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulating accumulation assumed Bacteria Bacterial betaine bind binding cellular cellular physiology compensatory mutations conditions conserved Control cyclic dacA Deletion demonstrated dependent on enzyme etiological agent expression function functional glycine glycine betaine group growth homeostasis host cell host cells host-pathogen interactions hyperosmotic identification identify Infection involved leads Loss loss-of-function loss-of-function mutation maintain mechanism medium Meningitis monophosphate mutant Mutation Neonatal nucleotide nucleotides opportunistic pathogen osmolyte osmoregulation osmotic osmotic regulation pathogen pathway phenotype Potassium predominant promoter Protein regulate Regulation second messenger second messengers secondary messenger septicaemia Streptococcus Streptococcus agalactiae susceptibility Transcription transcriptional viability [DOI] 10.1371/journal.pgen.1007342 PMC 바로가기 [Article Type] Research Article
Next generation sequencing of HIV-1 protease in the PIVOT trial of protease inhibitor monotherapy프로테아제 억제제 단독 요법의 PIVOT 시험에서 HIV-1 프로테아제의 차세대 시퀀싱Article Published on 2018-04-012022-09-06 Journal: Journal of Clinical Virology [Category] Communicable Disease, [키워드] Algorithm Antiretroviral therapy clinically Combination combination therapy Coverage described drug drug susceptibility Evidence examined frequencies Frequency frozen plasma Highlights HIV HIV-1 Laboratory leads Local low frequency median time Median viral load methodology monotherapy Mutation mutations next generation sequencing NGS objective Patient patients performed phenotypic plasma sample predict predicted Primary outcome protease Protease inhibitor Public Health England randomisation randomised reported resistance Result Ritonavir Sanger sequencing selected Sequencing Stanford Study design study drug suppressed susceptibility tested the median threshold Trial variant Viral Viral load was performed [DOI] 10.1016/j.jcv.2018.02.003 PMC 바로가기 [Article Type] Article
Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population세네갈 인구에서 RNASE3 (ECP)의 유전적 변이와 심각한 말라리아에 대한 취약성Research Published on 2018-02-052024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] Plasmodium falciparum Polymorphisms RNase3 (ECP) gene Senegal severe malaria susceptibility [DOI] 10.1186/s12936-018-2205-9 PMC 바로가기 [Article Type] Research
Antibiotics susceptibility of quinolones against Salmonella spp. strains isolated and molecularly sequenced for gyrA genearticle Published on 2018-01-312024-09-01 Journal: Microbial Pathogenesis [Category] 살모넬라증, [키워드] drug resistance gyrA quinolones Salmonella spp susceptibility [Article Type] article