ENDOCRINOLOGY IN THE TIME OF COVID-19: Clinical management of neuroendocrine neoplasms (NENs)Clinical Practice Guidance Published on 2020-08-092022-10-31 Journal: European Journal of Endocrinology [Category] COVID-19, MERS, [키워드] Chemotherapy clinical develop diagnosed disease Effect Follow-up functional genetic disorder growth Immunotherapy indolent interferon-alpha intestine life-threatening lung management medullary thyroid carcinoma Mild neoplasm neuroendocrine pancreas Pandemics Patient patients presenting receiving risk severity Surveillance Symptom syndrome targeted therapy therapy treated Treatment viral infection [DOI] 10.1530/EJE-20-0424 PMC 바로가기 [Article Type] Clinical Practice Guidance
Viral Ubiquitin and Ubiquitin-Like Deconjugases—Swiss Army Knives for InfectionReview Published on 2020-08-012022-10-28 Journal: Biomolecules [Category] Coronavirus, [키워드] Antiviral antiviral therapeutics cellular cellular processe coronavirus Defense enzyme Evidence functional functions herpesvirus Infection Innate immunity Modification Pathogenesis polypeptide promote Protein regulate Replication substrate target Type I IFN ubiquitin ubiquitin-like deconjugase viral infection viral life cycle virus virus cycle [DOI] 10.3390/biom10081137 PMC 바로가기 [Article Type] Review
Food and COVID-19: Preventive/Co-therapeutic Strategies Explored by Current Clinical Trials and in Silico StudiesReview Published on 2020-08-012022-11-01 Journal: Foods [Category] COVID-19, [키워드] acting acute respiratory syndrome carrier clinical clinical trial component components Compound compounds coronavirus coronavirus disease COVID-19 COVID-19 pandemic current enhancer etiological agent food functional Health Host immune system in silico in silico study in vitro in vivo infective Interaction interfere knowledge micronutrient Clinical trial micronutrients pandemic promote protein interaction Research SARS-CoV-2 Strategy target the SARS-CoV-2 therapeutic molecules Therapies virus [DOI] 10.3390/foods9081036 PMC 바로가기 [Article Type] Review
Ecotoxic response of nematodes to ivermectin, a potential anti-COVID-19 drug treatmentResearch article Published on 2020-08-012022-10-05 Journal: Marine pollution bulletin [Category] SARS, 치료법, [키워드] caused COVID-19 Diversity doses Ecotoxicity European France functional Italy Ivermectin ivermectin dose Meiobenthic nematodes nematode predict reduction in response Spain Treatment Trophic [DOI] 10.1016/j.marpolbul.2020.111375 [Article Type] Research article
Gut microbiota and Covid-19- possible link and implicationsReview article Published on 2020-08-012022-10-05 Journal: Virus research [Category] SARS, 유전자 메커니즘, [키워드] ACE2 receptor ACE2 receptors age alveolar epithelial cells binding cause caused COVID-19 diet disease Diseases Dysbiosis Elderly patient Enterocyte environmental factor Express faece functional genetics gut microbiome gut microbiota Immunity implication IMPROVE Improving infected patients Infection initiated intestinal epithelial cell Lung disease Lung infection Lung microbiota microbiota pandemic patients Perturbation Prophylactic reported respiratory virus role SARS-CoV-2 SARS-CoV-2 RNA small intestine Therapies Trial [DOI] 10.1016/j.virusres.2020.198018 [Article Type] Review article
Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populationsArticle Published on 2020-07-312022-10-31 Journal: Genes and Immunity [Category] COVID-19, MERS, [키워드] ACE2 African angiotensin-converting enzyme 2 applied COVID-19 disease entry of SARS-CoV-2 eQTL expression Factor functional Genetic genetic determinant Genetic predisposition glycoprotein host cell host cell membranes host genetics individual individuals inter-individual lower expression mechanism Population populations Quantitative receptor SARS-CoV-2 serine protease TMPRSS2 severity of COVID-19 susceptibility the SARS-CoV-2 TMPRSS2 TMPRSS2 expression Variability viral entry viral spike [DOI] 10.1038/s41435-020-0107-7 PMC 바로가기 [Article Type] Article
Prevalence and Predictive Value of Anemia and Dysregulated Iron Homeostasis in Patients with COVID-19 InfectionArticle Published on 2020-07-292022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95%CI Admission alteration Anemia anemic Biomarker clinical manifestations contribute COVID-19 outcome deficiency Frequency functional hemoglobin higher risk Hospital stay hospitalized COVID-19 patients hospitalized patient ICU ICU admission Immune-mediated in-hospital mortality increased mortality Inflammation initial intensive care iron iron homeostasis Iron metabolism majority mechanical ventilation Oxygenation Patient patients predict predicted Predictive Prevalence prevalent Retrospective analysis risk stratification SARS-CoV-2 significantly significantly higher subsequent systemic inflammation value with COVID-19 [DOI] 10.3390/jcm9082429 PMC 바로가기 [Article Type] Article
Transforming a General Hospital to an Infectious Disease Hospital for COVID-19 Over 2 WeeksPublic Health Published on 2020-07-282022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, [키워드] contagious Coronavirus Disease (COVID)-19 COVID-19 functional healthcare Healthcare system hospital hospital management hospitals infection control Infectious disease infectious disease hospital Isolation isolation unit organization Outbreaks over Patient Transforming Week [DOI] 10.3389/fpubh.2020.00382 PMC 바로가기 [Article Type] Public Health
Coronaviruses: a challenge of today and a call for extended human postmortem brain analysesNeurology and Preclinical Neurological Studies - Review Articles Published on 2020-07-282022-10-29 Journal: Journal of neural transmission (Vienna, Austria : [Category] COVID-19, SARS, [키워드] accumulate Alzheimer’s disease analyses Analysis animal model Brain Brain bank Brain pathology brain stem cardiorespiratory Cardiorespiratory centre clinical observation Cognitive dysfunction complex coronavirus Coronavirus infection Coronaviruses COVID-19 COVID-19 infection Deleterious Depression develop disorder disorders Drug discovery Evidence evidenced excluded functional Genetic HIV-1 invasive molecular Movement disorders multiple sclerosis neuroinvasion neurological Neurological symptoms/disorders neuroprotection Parkinson’s disease Parkinsonism pathological mechanism pathology Patient Postmortem studies problems Protective psychiatric symptomatology Region Research respiratory tract risk SARS-CoV-2 SARS-CoV-2 brain disorders Symptom therapy triggered unmet need while [DOI] 10.1007/s00702-020-02230-x PMC 바로가기 [Article Type] Neurology and Preclinical Neurological Studies - Review Articles
Contriving Multi-Epitope Subunit of Vaccine for COVID-19: Immunoinformatics ApproachesImmunology Published on 2020-07-282022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adaptation all age group Amino acid B cell B cells beta coronavirus binding epitope C-terminal can be used caused codon complex COVID-19 CTL CTL epitope cytotoxic T lymphocyte determine domains EAAAK linker Efficacy ENhance epitope Epitope prediction evaluated experiment experimental validation expression Fatality rate Final functional fusing help histocompatibility complex HTL Immune receptor immunoinformatics immunoinformatics approach in silico In silico cloning Incubation period linkers MHC-I MHC-II molecular docking mRNA Multi-epitope vaccine N-terminal performed positive predicted Prevalence producing Protein public health reduce RNA SARS-CoV-2 SARS-CoV-2 infections secondary structure sequence single-stranded susceptible T lymphocyte TAT the vaccine tlr-3 Treatment Vaccine virus vital role β-defensin [DOI] 10.3389/fimmu.2020.01784 PMC 바로가기 [Article Type] Immunology