The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegansGATA 전사 인자 egl-27은 꼬마선충의 스트레스 저항성을 촉진하여 노화를 지연시킵니다Research Article Published on 2012-12-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated activated Affect age aging aging process alteration animals Author Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans conserved daf-16 Delay Effect elegan expression Factor Factors found FoxO GATA GATA transcription factor Gene Genes heat stress identify IGF-1 impair IMPROVE increase inhibited insulin Intersection involved limit Longevity molecular mechanism molecular mechanisms mutant overexpression oxidative stress pathway Pathways promote Promoting PROTECT protective response protective responses receptor reduced required resistance response Signaling significantly Stress stress response stress responses suppresse survival target transcription factor wild-type worm worms [DOI] 10.1371/journal.pgen.1003108 PMC 바로가기 [Article Type] Research Article
Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection작은 분자에 의한 숙주 면역 방어의 자극은 세균 감염으로부터 C. elegans를 보호합니다Research Article Published on 2012-06-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect analysis antibiotic Antibiotics ATF-7 Author Bacterial Bacterial infection Bacterial infections bacterial pathogen Bacterial pathogens Caenorhabditis elegan Caenorhabditis elegans cellular processe cellular processes Compound conserved effector molecule Efficacy elegan expression Gene Genes growth Host immune response host immunity identify immune immune regulators immunostimulatory Infection Interaction low molecular weight mechanism mechanism of action mode molecule molecules mutants nematode offer Pathogens pathway promote PROTECT Pseudomonas aeruginosa required small molecule Small molecules stimulate Stimulation tested therapy These data Transcription transcription factor Transcriptome Treatment variety [DOI] 10.1371/journal.pgen.1002733 PMC 바로가기 [Article Type] Research Article
The Adjuvanticity of an O. volvulus -Derived r Ov -ASP-1 Protein in Mice Using Sequential Vaccinations and in Non-Human PrimatesResearch Article Published on 2012-05-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Activation adjuvant adjuvanticity administration anti-RBD antibody Antibody Response antigens bystander Course DC different Effectiveness Efficacy element first vaccination functional host response IFN-γ IgG2a IL-2 IL-6 immunized induce Influenza virus maturation mice naïve NHPs non-human primate not affect Onchocerca volvulus primate promote promoted Protective protective immune response Protein provided RBD reported retained SARS-CoV spike protein sera subsequent Th1 Th1 cytokines Th2 response the receptor-binding domain titre TNF-α upregulated utility vaccination Vaccine vaccine antigen virus strains was used [DOI] 10.1371/journal.pone.0037019 PMC 바로가기 [Article Type] Research Article
A Single Polar Residue and Distinct Membrane Topologies Impact the Function of the Infectious Bronchitis Coronavirus E ProteinResearch Article Published on 2012-05-032022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activities adopted affected Antiviral strategies Author coronavirus correlated defined different disrupt disrupting domain E protein examined found function functions Golgi Host hydrophobic IBV identify Impact implicated in vitro independent infected cells Infection infectious Infectious Bronchitis Virus Infectious virus less mapped mechanism of action membrane membrane protein mutant occur Particle Particles predicted promote Protein reported required residue secretory pathway Substitution thought Topology transmembrane virion assembly virus virus [DOI] 10.1371/journal.ppat.1002674 PMC 바로가기 [Article Type] Research Article
A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity타고난 면역에 대한 결과와 함께 전사 조절에서 RBF1 및 dCAP-D3의 공유 역할Research Article Published on 2012-04-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activate Activation affected Alter AMP AMPs antimicrobial peptide Author Bacteria Bacterial infection Bacterial pathogens Cell cell cycle cell cycle arrest cell cycle gene cell cycle genes chromatin chromatin condensation classic Cluster condensation Condensin consequence conserved decrease DNA Drosophila Drosophila melanogaster expression fat function Gene gene cluster gene clusters Genes homolog homologs human cell human cells identify immune response immune system in vivo induce Infection Innate innate immune genes Innate immunity Interaction mitosis mitotic Pathogens peptide pRB previous study promote Protein Proteins RBF1 Region regulate regulated Regulation repress retinoblastoma retinoblastoma protein role shown subset subunit suggested transcript Transcription Tumor tumor suppressor undergo unique [DOI] 10.1371/journal.pgen.1002618 PMC 바로가기 [Article Type] Research Article
Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein ComplexResearch Article Published on 2011-10-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Analysis antiviral drug assays Author biochemical canonical catalytic catalyzed cellular cofactor complex composed coronavirus demonstrated different Donor drug target drugs ENCODE eukaryotic eukaryotic virus found function Immune escape in viral indicated innate immune insight inter-molecular Interaction methylated methyltransferase modify mRNA mRNA stability mRNAs non-structural protein nsp14 promote protein translation required ribose ribosome RNA RNA stability RNAs S-adenosyl-L-methionine SAM SARS Coronavirus SARS-CoV shown stimulatory Structural analysis subunit subunits unique Viral RNA virus [DOI] 10.1371/journal.ppat.1002294 PMC 바로가기 [Article Type] Research Article
Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) InfectionResearch Article Published on 2011-07-072022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activate anti-IFN-γ anti-TNF-α Author blockade cascades CD4 CD8 cells characteristic co-expressed Coagulation Combination Control damaged demonstrated described determined exhibited expression Fgl2 FH fibrinogen Fluorescence fulminant viral hepatitis functional hepatocellular IFN-γ immunopathological immunopathological damage Immunotherapy in vivo Infection inhibitory receptor initiate injection investigated led to limit liver Liver damage Lymph node lymph nodes mAb Macrophage maintain mechanism mice Mortality mortality rate mRNA multiple organs murine hepatitis virus Necrosis NK cell occurred organ Pathogenesis peripheral tolerance produced promote Protein Quantitative reduced related RT-PCR sensitive Signaling significantly higher spleen T cells tissue tissue damage tissue lesion tissue lesions TNF-α Transcription was determined wild type wild-type [DOI] 10.1371/journal.ppat.1001347 PMC 바로가기 [Article Type] Research Article
A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegansCaenorhabditis elegans에서 p38 MAPK 신호 전달의 감소는 면역 노화의 기초가 됩니다Research Article Published on 2011-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addressed age aging amplify Author Bacteria Bacterial Bacterial infection Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans change conserved cycle death Decline declines Defense defined Deterioration elegan examined exhibit Genetic Host host defense human pathogen humans immune function immunosenescence impair implicated increase in Infection innate immune Innate immunity intestinal intestinal tissue involved leads MAPK mice mitogen mitogen-activated protein kinase molecular basis molecular mechanism motion pathogen pathway phenomenon PMK-1 proliferation promote Protein protein kinase Pseudomonas aeruginosa regulate signaling pathway susceptibility tissue damage turn [DOI] 10.1371/journal.pgen.1002082 PMC 바로가기 [Article Type] Research Article
What Internet Services Would Patients Like From Hospitals During an Epidemic? Lessons From the SARS Outbreak in TorontoOriginal Paper Published on 2005-08-032022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome affected age Analysis Care clinics communicable diseases, emerging conducted Descriptive statistics determine emergency situation English Epidemic expressed Health health condition health information Health Service help hospital identify IMPROVE infectious Infectious disease information information services international health Internet Laboratory lesson Like logistic regression model maintain mean Most patient objective organization outbreak pandemic Patient predictor professional promote provided public health Questionnaires Regression responsible restrict Result searched selected service Severe acute respiratory syndrome Toronto unique Web were used World wide web [DOI] 10.2196/jmir.7.4.e46 PMC 바로가기 [Article Type] Original Paper
A Three-Stemmed mRNA Pseudoknot in the SARS Coronavirus Frameshift SignalResearch Article Published on 2005-06-172022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] Affect analysis antiviral drugs antiviral therapeutics assay conserved coronavirus Coronaviruses double-stranded RNA Efficiency frameshift fusion protein GenBank database Gene Expression Genetic Genome in vivo Inspection Interaction Local motif mRNA Mutation nuclear ORF1a ORF1b other coronavirus overlap predicted promote Proteins pseudoknot Region RNA RNA virus SARS virus SARS-CoV sequence signal Structure supported two-dimensional virus yeast [DOI] 10.1371/journal.pbio.0030172 PMC 바로가기 [Article Type] Research Article