Changes in Severity of Influenza A(H1N1)pdm09 Infection from Pandemic to First Postpandemic Season, GermanyArticle Published on 2013-05-012023-06-08 Journal: Emerging Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] age groups expedited Influenza Influenza A(H1N1)pdm09 virus risk factor severe disease viruses [DOI] 10.3201/eid1905.130034 PMC 바로가기
A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)게놈 전체에 걸친 통합 게놈 연구는 엡스타인-바 바이러스 핵 항원 1(EBNA-1)에 대한 항체에 영향을 미치는 유전적 요인을 국소화합니다.Research Article Published on 2013-01-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Adult adverse outcome adverse outcomes Analysis analysis antibody antibody levels Antigen approach association Author Autoimmune disorders best Burkitt lymphoma Cancer cancers Candidates chromosome chromosome 6 concerning dataset disease Disease progression DQB1 DRB1 EBV Epstein Barr virus Epstein-Barr virus Evidence evidence of examined expression data Factor family members focus foreign antigen foreign antigens found Gene Gene Expression Genetic genetic factors Genome HLA HLA locus HLA-DQB1 HLA-DRB1 Hodgkin lymphoma Host human leukocyte antigen IgG antibodies IgG antibody immune function immune system independent individual infect Infected Infection infectious Infectious disease infectious mononucleosis investigated involved joint leukocyte linkage loci locus lupus erythematosus lymphocyte lymphoproliferative disorders malignancies malignancy measure mechanism MHC class MHC class II multiple sclerosis nasopharyngeal lymphoma not found nuclear overlap P -value pathogen Pathogens prevalent provide regulate related replicated Research severe complication severe complications severe disease significantly SNP SNPs susceptibility susceptibility loci systemic lupus erythematosus T cells virus was obtained [DOI] 10.1371/journal.pgen.1003147 PMC 바로가기 [Article Type] Research Article
The dominance of human coronavirus OC43 and NL63 infections in infantsArticle Published on 2011-12-192022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, MERS, [키워드] 229E addition childhood children determine disease elicit Epidemiology explain Frequency HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 healthy children HKU1 hospital Hospitalized human coronavirus Human coronavirus human coronavirus OC43 Immunity indication Infant infect infecting Infection infections less majority mild infection natural infection Newborn NL63 objective OC43 occur pathogenic positive PROTECT real time respiratory infection respiratory tract Result RT-PCR sequence Seroconversion seroconverted serology severe disease study group subsequent was determined [DOI] 10.1016/j.jcv.2011.11.011 PMC 바로가기 [Article Type] Article
Prevalence and Phylogeny of Coronaviruses in Wild Birds from the Bering Strait Area (Beringia)Research Article Published on 2010-10-292022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis Area Bering Strait Beringia Bird bronchitis cause collected costly CoV CoV infection CoVs detected Epidemiology examined Frequency Genetic Health host range Human IBV investigated Mild novel coronavirus pathogenic performed phylogenetic analyses related reservoir respiratory viral disease RT-PCR SARS-coronavirus severe disease Spread statistical virus virus widespread [DOI] 10.1371/journal.pone.0013640 PMC 바로가기 [Article Type] Research Article
SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent MechanismResearch Article Published on 2010-04-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] acute lung injury acute respiratory syndrome affecting alveolar inflammation ARDS Author BALB/c mice caused cell proliferation clinical disease coronavirus death demonstrated Dependent died Diffuse alveolar damage ENhance Epidemic evaluated highly pathogenic I, II independent Infected Infection innate immune innate immune response Innate immunity interferon interferon signaling knockout mice lack liver Lung disease Lung injury Lung pathology MA15 mechanism mice molecular mechanism Mortality Mouse models other tissue outcomes Pathogenesis Pathways Post-infection PROTECT Protein pulmonary fibrosis pulmonary lesion question receptor regulated respiratory respiratory virus SARS Coronavirus SARS pathogenesis SARS-CoV SARS-CoV infection severe severe disease Signaling spleen Stat1 the epidemic Type type I type III interferon viral pathogenesis virus virus pathogenesis virus titer Virus-host interaction viruses weight loss wildtype [DOI] 10.1371/journal.ppat.1000849 PMC 바로가기 [Article Type] Research Article
Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected MiceResearch Article Published on 2009-10-232022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activated Activation Adaptive immune response allergic alveolar macrophage animal model Anti-viral Antigen Author BALB/c mice caused characterized correlated CoV dendritic cell dendritic cells deplete develop DLN draining lymph node Epidemic feature Human human disease human population humans immune response individual inefficient Infected Infection inhibitory inhibitory effect initial Liposome lung lymphopenia MA15 Macrophage mice morbidity and mortality mouse-adapted SARS-CoV Novel coronavirus occurred Patient Poor Prevent prolonged virus persistence PROTECT respiratory Respiratory disease response severe severe disease severe respiratory disease T cell response T cells Therapies TLR3 Toll-like receptor transfer treated virus virus clearance virus excretion virus-specific T cell [DOI] 10.1371/journal.ppat.1000636 PMC 바로가기 [Article Type] Research Article
Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in ChinaArticles Published on 2009-09-272022-10-29 Journal: Philosophical Transactions of the Royal Society B: [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] Streptococcus suis addition Asia Avian Influenza Bacteria caused China coronavirus disease EHEC Escherichia coli expand fatality H5N1 highly pathogenic Host host range human pathogen implication infect Infection Influenza virus Isolation mammalian Molecular epidemiology occur outbreak pathogen pathogenicity PRRSV reproductive SARS-CoV serotype severe disease Shock Spread Streptococcus subsequent syndrome variant virus viruses zoonotic zoonotic pathogens zoonotic threat [DOI] 10.1098/rstb.2009.0093 PMC 바로가기 [Article Type] Articles
SARS coronavirus and innate immunityArticle Published on 2007-04-232022-11-01 Journal: Virus research [Category] Coronavirus, Fulltext, MERS, SARS, [키워드] Arm Cell culture contribute coronavirus biology Coronavirus infection coronavirus pathogenesis disease evade function gene product highly pathogenic Host host immune system Human in vivo innate immune response innate immune system Innate immunity Interaction interferon knowledge mechanism molecular mechanism outcomes Pathogenesis pathway RNA virus SARS Coronavirus SARS-CoV severe disease Signaling the interferon viral gene virulence [DOI] 10.1016/j.virusres.2007.03.015 PMC 바로가기 [Article Type] Article