Loss of Humoral and Cellular Immunity to Invasive Nontyphoidal Salmonella during Current or Convalescent Plasmodium falciparum Infection in Malawian Children말라위 아동에서 현재 또는 회복기 말라리아 감염 중 침습성 비장티푸스 살모넬라에 대한 체액 및 세포 면역의 손실Article Published on 2017-05-172024-07-29 Journal: Clin Vaccine Immunol [Category] 말라리아, 살모넬라증, [키워드] children Immunity malaria Salmonella susceptibility [DOI] 10.1128/CVI.00057-17 PMC 바로가기
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations단일 특성 및 다중 특성 게놈 전체 연관 분석을 통해 아프리카 계통 인구의 혈압에 대한 새로운 유전자좌 식별Research Article Published on 2017-05-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect African African American African Americans allele alleles analyses Analysis analyzed angiotensin biologic blood pressure CDH17 cells complications conducted contributing to Diastolic blood pressure disability disease driven by enrichment Evidence experimental models expressed expression Factor FRMD3 functional annotation Genes Genetic studies genome-wide association Genome-wide association study genome-wide significance genomic region Health health problem hypertension identify immune independent individual kidney kidney tissue LLPH loci locus mice Mortality mRNA expression nine performed Population populations provide reached reported Research risk Support susceptibility susceptibility loci systolic TARID TCF21 TMBIM4 traits variant Vascular while [DOI] 10.1371/journal.pgen.1006728 PMC 바로가기 [Article Type] Research Article
A Programmed Cell Death-1 Haplotype is Associated with Clearance of Hepatitis B VirusArticle Published on 2017-05-012023-06-19 Journal: Annals of clinical and laboratory science [Category] B형 간염, [키워드] Chronic HBV infection Programmed cell death 1 (PD-1) Progress Single nucleotide polymorphism (SNP) susceptibility
Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya서부 케냐 어린이에서 Fcγ 수용체 IIA, IIIA 및 IIIB 유전적 다형성과 중증 말라리아 빈혈에 대한 감수성 간의 연관성Research Article Published on 2017-04-202024-08-12 Journal: BMC Infectious Diseases [Category] 말라리아, [키워드] FcγRs Malaria anemia Polymorphisms susceptibility [DOI] 10.1186/s12879-017-2390-0 PMC 바로가기 [Article Type] Research Article
Evidence for the evolutionary steps leading to mecA -mediated β-lactam resistance in staphylococci포도상구균에서 mecA 매개 β-락탐 내성으로 이어지는 진화 단계에 대한 증거Research Article Published on 2017-04-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation acquisition adaptation Amino acid Analysis antibiotic Antibiotic resistance Antibiotics Author Bacteria Bacterial Bayesian analysis binding binding domain cell wall cell wall synthesis changes in chromosome Community core genome development domain driving epidemiologically Evolution exposure to food additives gene encoding Genetic genetic background genomes highlight homologue identify involved isolates livestock mechanism mechanisms methicillin methicillin-resistant Staphylococcus aureus Mortality MRSA mutation rate Mutation rates non-binding nucleotide occur occurred oxacillin Pandemics PBP penicillin phenotype Phylogenetic analysis precursor predicted profiles promoter promoters Protein representing resistance gene resource responsible S . aureus SCC selective sequence sequence alignments sequenced genome single-nucleotide polymorphism SNP species Spread Staphylococcus Staphylococcus aureus strain Substitution substitutions susceptibility variety was performed [DOI] 10.1371/journal.pgen.1006674 PMC 바로가기 [Article Type] Research Article
Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entryArticle Published on 2017-03-282022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] alphacoronavirus aminopeptidase aminopeptidase N APN applied binding blocked cause Cell cell entry coronavirus diarrhea epidemic diarrhea examined exhibited expressed expressing expression functional gastroenteritis Genetic Genome had no HCoV-229E Hela host cell receptor Huh7 human cell line human coronavirus 229E indicated infect Infection intestinal epithelium knockout MDCK cell observation overexpression pathogenic coronavirus PEDV Porcine epidemic diarrhea virus preincubation Protein receptor reported required Result resulting S1 subunit Surface glycoprotein susceptibility susceptible TGEV these cell viral spike virus Virus cell entry viruses [DOI] 10.1016/j.virusres.2017.03.018 PMC 바로가기 [Article Type] Article
Worry experienced during the 2015 Middle East Respiratory Syndrome (MERS) pandemic in KoreaResearch Article Published on 2017-03-082022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] analyzed cross-sectional survey detrimental disease early stage Factor greater Health status help information initial Level management MERS Middle East Multivariate analysis ordinal logistic regression outbreak pandemic reliability reported respiratory respondent Result risk stages Stress susceptibility was performed women Worry [DOI] 10.1371/journal.pone.0173234 PMC 바로가기 [Article Type] Research Article
Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다Research Article Published on 2017-03-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall [DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article
A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy게놈 전체 관련 연구에서 lncRna가 나병의 병리학적 염증 반응에 대한 위험 인자로 확인됨Research Article Published on 2017-02-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 한센병, [키워드] 95% CI Affect Analysis association Brazil chromosome clinically Combined dataset disease eQTL etiologies evaluated Evidence evidence of example excessive inflammatory response experimental evidence Factor Genetic genetic control genetic factors Genetic variant Genome Genome-wide association study genomic GWAS GWAS meta-analysis Host IBD identify independent Inflammatory bowel disease inflammatory disorders Inflammatory response initial leprosy lncRNA loci locus mechanism nerve nerve damage occur offspring overlap Patient peripheral nerve reaction Reactions replicated Replication responses risk risk factor Risk factors separated SNP SNPs Support susceptibility undergo [DOI] 10.1371/journal.pgen.1006637 PMC 바로가기 [Article Type] Research Article
Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease유전 변이는 점막 염증 질환에서 T-bet 결합 및 유전자 발현을 변경합니다Research Article Published on 2017-02-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect alleles Alter alteration Arthritis association autoimmune conditions Autoimmune disease Autoimmune diseases Autoimmunity autoinflammatory disease binding binding site Cancer CD4+ T cell CD4+ T cells celiac disease certainty ChIP ChIP-seq condition contribute Crohn’s disease decreased expression disease disease-associated distal DNA elements environmental factors eQTL examined exons expression expression quantitative trait locus Gene Expression Genetic Genetic polymorphism genetic polymorphisms Genetic variant genetic variants Genetic variation Genome-wide association studies helper cell heterozygous identify IL18RAP immune response in vitro in vivo increased risk individual Infection Inflammatory inflammatory disease Inflammatory diseases Lineage locus majority mechanism modulating molecular mechanism mucosal nucleotide Other polarization polymorphism protective immunity Protein psoriasis Quantitative quantitative trait locus Region regulate Regulatory represse reveal rheumatoid arthritis Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs subsequent susceptibility susceptibility to infections T cell T cells T helper cell TBX21 Th1 transcription factor transcription factors transcriptional ulcerative colitis underlie variant [DOI] 10.1371/journal.pgen.1006587 PMC 바로가기 [Article Type] Research Article