MERS-CoV virus-like particles produced in insect cells induce specific humoural and cellular imminity in rhesus macaquesResearch Paper Published on 2017-02-212022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] alum adjuvant approved baculovirus cause Cell cellular disease drug electron microscopy elicited ELISPOT endpoint titer expression Fatality rate Human immune response Immunity induce inoculated insect cell lack MERS-CoV Microscopy Middle East Middle East respiratory syndrome Coronavirus nonhuman primates outbreak produced public health RBD Receptor binding domain respiratory syndrome coronavirus rhesus macaque rhesus macaques severe respiratory disease specific IgG antibody Spread Vaccine vaccine candidate virus Virus-like particle virus-like particles virus-neutralizing antibody VLP [DOI] 10.18632/oncotarget.8475 PMC 바로가기 [Article Type] Research Paper
Effective inhibition of MERS-CoV infection by resveratrolResearch Article Published on 2017-02-132022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] addition administration analyzed Antiviral antiviral activity antiviral medicine antiviral property Apoptosis approved can be used cause cellular Concentration coronavirus demonstrated down-regulated Effectiveness expression in vitro inhibited inhibition inhibitory MERS-CoV MERS-CoV infection MERS-CoV virus infection MERS-CoV-infected patients Middle East Middle East Respiratory Syndrome Virus morbidity and mortality MTT neutral red nucleocapsid performed Plaque assay Protein protein expression quantitative PCR reduce Replication respiratory Result resveratrol significantly survival survival rate treat Treatment Vaccine VERO E6 cells viral pathogen Viral RNA virus infection [DOI] 10.1186/s12879-017-2253-8 PMC 바로가기 [Article Type] Research Article
Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus InfectionArticle Published on 2016-08-192022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Against animal model approved Arabian Peninsula caused clinical development coronavirus death disease Human human infections Human monoclonal antibody Infection infections lack lethal m336 mAb mAbs medical countermeasure MERS-CoV MERS-CoV infection mice Middle East morbidity and mortality Neutralizing outbreak Passive Prophylactic respiratory robust shown Support therapeutic efficacy transgenic mice treated weight loss [DOI] 10.1038/srep31629 PMC 바로가기 [Article Type] Article
A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primatesArticle Published on 2015-09-042022-11-01 Journal: Science Translational Medicine [Category] Coronavirus, [키워드] acute respiratory syndrome antigen-specific neutralizing antibody antiviral therapy approved Arabian Peninsula cause caused cellular immunity characteristic Consensus coronavirus deaths disease DNA vaccine Europe exhibited increase in induce Infection lack Lineage macaque macaques MERS MERS coronavirus MERS spike protein MERS-CoV mice Middle East morbidity Mortality nosocomial pathogen Pneumonia Prevent protective immunity protective response Protein Radiographic respiratory syndrome coronavirus rhesus macaque route of infection SARS-CoV seroconverted syndrome The United States Transmission treat Vaccine viral challenge virus-neutralizing [DOI] 10.1126/scitranslmed.aac7462 PMC 바로가기 [Article Type] Article
Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak controlReview Published on 2015-08-282022-10-31 Journal: Experimental & Molecular Medicine [Category] Coronavirus, [키워드] acute respiratory syndrome approved can be used cause clinically Coronavirus infection cough death deaths develop drug target Fatality rate Fever Health highlight hospital Human infected individuals infections MERS-CoV MERS-CoV infection Middle East Multiorgan dysfunction Occurrence outbreak raised reported respiratory syndrome coronavirus respiratory tract infection South Korea spread to syndrome therapeutic targeting thought Transmission transmitted virus [DOI] 10.1038/emm.2015.76 PMC 바로가기 [Article Type] Review
A Sweet Spot for Molecular Diagnostics: Coupling Isothermal Amplification and Strand Exchange Circuits to GlucometersArticle Published on 2015-06-082022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Amplicon amplicons amplified approved biological sample can be used cell lysate circuit coupling Ebolavirus exchange Glucose high temperature isothermal isothermal amplification Loop-mediated isothermal amplification non-specific nucleic acid nucleic acid amplification point-of-care probe respiratory syndrome coronavirus Saliva sensitivity spot sputum strand triggered virus detection Zaire [DOI] 10.1038/srep11039 PMC 바로가기 [Article Type] Article
Overview of the 3rd isirv-Antiviral Group Conference – advances in clinical managementMeeting Report Published on 2015-01-152022-10-30 Journal: Influenza and Other Respiratory Viruses [Category] Coronavirus, [키워드] Antiviral antivirals approved Clinical management Conference current group highlight Immunocompromised Immunocompromised patient Influenza influenza virus MERS-CoV pandemic respiratory respiratory infection respiratory syncytial virus respiratory virus rhinovirus RSV Treatment Vaccine [DOI] 10.1111/irv.12293 PMC 바로가기 [Article Type] Meeting Report
FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelinationResearch Published on 2014-08-202022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] Affect Anti-viral immune response approved CD4+ CD8+ T cell Central nervous system clinical disease CNS correlated cytokine production cytolytic Demyelination disease disease severity disease-causing dose drug Effect effective examined exhibited expression flow cytometry food FTY720 IFN-γ infiltration Inflammatory inhibiting Lymph node lymphocyte mice Migration modulate morbidity and mortality Mortality mouse hepatitis virus multiple sclerosis Neuroinflammation neurologic neurotropic not affect occur Patient Post-infection proliferation recorded reduce reduction in Result S1P receptor severity staining T lymphocyte T lymphocytes Therapeutic benefit TNF-α treated Treatment viral replication viral-induced virus virus-specific T cell was determined were infected [DOI] 10.1186/s12974-014-0138-y PMC 바로가기 [Article Type] Research
Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral DrugsResearch Published on 2004-04-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome agents Antiviral Antiviral agents antiviral drug antiviral drugs antivirals approved caused clinical testing clinically Compound coronavirus Coronavirus infection Culture cultured cell Cytopathic effect drug effective in vitro Infectious disease inhibition inhibitors interferon interferons investigated leukocyte neuraminidase inhibitors nucleoside analogs protease inhibitors SARS virus SARS-CoV SARS-CoV infection severe Severe acute respiratory syndrome Subtypes Support transcriptase treat Treatment was used [DOI] 10.3201/eid1004.030458 PMC 바로가기 [Article Type] Research