The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP막 단백질 ANKH는 구연산염과 ATP의 세포 내보내기를 매개하여 뼈의 기계적 성능에 중요합니다Research Article Published on 2020-07-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Affect affecting ANKH ankylosis Arthritis ATP blood vessel blood vessels bone bone matrix Brain calcification cells cellular citrate Concentration contribute Critical cultured cell cultured cells cytosol disposition ENPP1 excretion expected explain Extracellular extracellular ATP functional hands homeostasis Human hydroxyapatite in urine in vivo inhibitor joint joints membrane protein metabolite metabolomics mice muscle Mutation nucleoside nucleoside triphosphates pathway Patient phenotype phosphodiesterase plasma Prevent provide Pyrophosphatase Pyrophosphate reduced released spine thought tissues underlie undetectable Urine wild type [DOI] 10.1371/journal.pgen.1008884 PMC 바로가기 [Article Type] Research Article
Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory ResponseArticle Published on 2020-07-072022-10-31 Journal: Genes [Category] COVID-19, SARS, [키워드] activated Activation acute inflammatory response acute respiratory syndrome Analysis Antiviral antiviral response bioinformatics Biomarkers bronchial bronchial epithelial bronchial epithelial cell category caused Cell cell death cells Community coronavirus Course COVID-19 differentially expressed disease expressed gene expression functional functional annotation gene expressions gene target hallmark highlight host cells host response Ifi44 IFI44L IFIT1 IFIT2 IFIT3 IFITM1 IFN IFN response IgG immune response Immunoglobulin in vitro induction Infection innate response interferon Interferon lambda investigated involved IPA IRF9 landscape lncRNA lncRNAs Long long noncoding RNA lung tissue MAPK MX1 Necrosis network analysis NHBE OAS2 OAS3 Ontology pathogenesis of COVID-19 pathogenic Pathway analysis Patient Replication Research response RNA role SARS-CoV-2 SARS-COV-2 infection spread of COVID-19 suppressed tissue TNF Transcriptome upregulated upstream viral infection Viral protein with COVID-19 [DOI] 10.3390/genes11070760 PMC 바로가기 [Article Type] Article
SARS-CoV-2, ACE2, and Hydroxychloroquine: Cardiovascular Complications, Therapeutics, and Clinical Readouts in the Current SettingsReview Published on 2020-07-072022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Analysis angiotensin-converting enzyme 2 benefit cardiovascular cardiovascular complication cardiovascular disease (CVD) Cardiovascular function cardiovascular system caused clinical clinical settings clinics coronavirus coronavirus disease COVID-19 Critical current drug Efficacy functional global healthcare HCQ Hydroxychloroquine immunomodulatory activities Intervention key consideration physiological provide recommendation report SARS-CoV-2 SARS-CoV-2 replication setting target receptor targets Therapeutics while widespread [DOI] 10.3390/pathogens9070546 PMC 바로가기 [Article Type] Review
A Proposal for Multidisciplinary Tele-Rehabilitation in the Assessment and Rehabilitation of COVID-19 SurvivorsArticle Published on 2020-07-072022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] acute respiratory syndrome affected assessment Care Community contagious coronavirus COVID-19 discharge disease effective event facilitate Follow-up functional global pandemic hospital discharge Hospitalization Infection intensive care mechanical ventilation MONITOR multi-disciplinary tele-rehabilitation occur offer organ system pathway Patient patients pulmonary rehabilitation rehabilitation required Respiratory system respond resulting severe cases survivor the disease therapy transmitted unlikely [DOI] 10.3390/ijerph17134890 PMC 바로가기 [Article Type] Article
An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessmentArticle Published on 2020-07-062022-10-04 Journal: Nature Communications [Category] SARS, 진단, 치료기술, [키워드] antibody Antibody testing assays Characteristics correlated COVID-19 COVID-19 pandemic cut-off detect diagnostics eight ELISA functional global pandemic Immunoglobulin implementation Laboratory techniques and procedures Medical research outcome Population screening protective antibodies Receptor binding domain SARS CoV-2 SARS-CoV-2 selected serological Serological assay serology Severity of disease Stage Support variety viral infection Virus neutralization virus neutralizing antibodies [DOI] 10.1038/s41467-020-17317-y PMC 바로가기 [Article Type] Article
Innate immunity in COVID-19 patients mediated by NKG2A receptors, and potential treatment using Monalizumab, Cholroquine, and antiviral agentsResearch article Published on 2020-07-012022-10-05 Journal: Medical Hypotheses [Category] 치료제, [키워드] antibody antiviral agent Antiviral agents blocking Blood Cancer cancers CD8 CD8+ CD8+ cell Cell Chloroquine clinical trials COVID-19 COVID-19 infected patient COVID-19 patient CTLs cytokine secretion cytotoxic cytotoxicity disease Disease progression effective functional generate healthy controls healthy individuals Host immune response Immunity individual inhibiting inhibitory Innate innate immune response Innate immunity interferon lymphocyte mechanism mild infection modulated Monalizumab natural neutrophil NK cell NK cell function NK cells NKG2A Novel coronavirus outbreak over-expressing overexpression Patient Phase 2 Potential treatment receptor receptors reduced required resulting SARS SARS-CoV-2 severe COVID-19 Severe infection Side effect significantly significantly lower T-cell treated tumor growth tumor progression viral pathogen viruses weakened immune system [DOI] 10.1016/j.mehy.2020.109777 [Article Type] Research article
Regulatory Cross Talk Between SARS-CoV-2 Receptor Binding and Replication Machinery in the Human HostPhysiology Published on 2020-06-302022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Activation cardiovascular disease COVID-19 diabete dissect FIVE functional Host host mechanism host protein hub protein Human human lung hypertension in viral independent Infection initial lung mechanism MERS miRNA targets miRNAs MOST Pathogenesis Protein receptor Receptor binding regulated Replication risk SARS-CoV-2 SARS-COV-2 infection Seven Severity of infection Signaling Systems biology Transcriptome viral infection viral replication virus [DOI] 10.3389/fphys.2020.00802 PMC 바로가기 [Article Type] Physiology
Immune and Metabolic Signatures of COVID-19 Revealed by Transcriptomics Data ReuseImmunology Published on 2020-06-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] absence Activation addition affected approach BALF Bronchoalveolar lavage fluid caused cells characterized chemokines complex coronavirus disease COVID-19 COVID-19 patient Critical death Deceased demonstrated dysregulated expression expression of gene feature functional Humoral immunity IAV immunopathological individual Inflammation inflammatory signaling Influenza innate immune response interferon involved leukocyte leukocytes lung tissue Meta-analysis metabolic metabolic pathway metabolism mitochondrial molecular mechanism neutrophil overcome oxidative phosphorylation pandemic pathophysiology Perspective progression promote reported respiratory virus response Revealed robust SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection signature significant enrichment target the disease These data tissue transcriptional transcriptome datasets transcriptomic profile transcriptomics type I viruses [DOI] 10.3389/fimmu.2020.01636 PMC 바로가기 [Article Type] Immunology
Cerebral ischemic and hemorrhagic complications of coronavirus disease 2019Research Published on 2020-06-262022-10-29 Journal: International Journal of Stroke [Category] COVID-19, MERS, SARS, [키워드] acute cerebrovascular disease addition age Analysis Aneurysm angiotensin (1–7) angiotensin-converting enzyme 2 case sery cerebral Cerebral venous thrombosis Cerebrovascular disease Complication conducted coronavirus disease Coronavirus disease 2019 diagnosed discharge eight feature female FIVE functional Hemorrhagic hypercoagulable incidence Infarction Intervention large vessel literature review Mortality mortality rate neurological manifestation objective Pathologies pathology pathophysiology Patient patients performed reperfusion Result Retrospective study rupture scale score severe acute respiratory syndrome coronavirus 2 stroke the mean Thrombectomy thrombosis total mortality total sample size vasculature venous [DOI] 10.1177/1747493020937189 PMC 바로가기 [Article Type] Research
ACE2 and TMPRSS2 variation in savanna monkeys ( Chlorocebus spp.): Potential risk for zoonotic/anthroponotic transmission of SARS-CoV-2 and a potential model for functional studiesResearch Article Published on 2020-06-232022-10-28 Journal: PLoS ONE [Category] COVID-19, Fulltext, MERS, SARS, 조류인플루엔자, [키워드] ACE2 ACE2 binding African amino acid residue approach Asian binding efficiency cause caused Chlorocebus colony Community Comparative coronavirus SARS-CoV-2 COVID-19 COVID-19 pandemic criteria Critical disease entry receptor Epidemics functional functional variation genomic genomic data Health humans Interaction many cases Missense missense variant non-human primate one health Population Potential priming progression Protein receptor Receptor binding domain reduce reduced Research risk SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection Savanna Spike protein splice sub-Saharan Africa suggested susceptibility susceptible therapy TMPRSS2 transfer transmission of SARS-CoV-2 Vaccine variant variants Variation virus widespread [DOI] 10.1371/journal.pone.0235106 PMC 바로가기 [Article Type] Research Article