susceptibility

[키워드] affected age of onset alleles allelic combination animal model artificial selection association Autoimmune disease biological samples canine chromosome chromosomes Combination complex complex disease complex diseases components conducted conserved conserved regions contribute correlated dermatomyositis disease disease pathogenesis Disease progression disease risk driven by dysfunction encoding Evidence explain exploration Frequency gene-gene interaction Genetic genetic interactions genetic risk genetic risk factor genetic study Genome Genome-wide association studies Genome-wide association study Genotype genotype-phenotype correlation genotypic genotyping Haplotype haplotypes healthy heterogeneity high risk highlight homozygosity human populations identify immunological impacted incidence independent independent of indicated Inflammatory inflammatory disease influences Interaction inverse correlation investigated involved Isolation juvenile dermatomyositis loci major histocompatibility complex MAP3K7CL mapping MHC moderate muscle Myopathy nine PAN2 pattern Phenotypes polymorphism Probability provided Region risk risk allele skin subjects susceptibility susceptibility loci target targets the major histocompatibility thought unique utility Vasculopathy whole genome
[DOI] 10.1371/journal.pgen.1006604 PMC 바로가기 [Article Type] Research Article