Rationale and design of the “Tocilizumab in patients with moderate to severe COVID-19: an open-label multicentre randomized controlled” trial (TOCIBRAS)"중등도에서 중증의 COVID-19 환자에 대한 토실리주맙: 공개 라벨 다기관 무작위 통제" 시험(TOCIBRAS)의 근거 및 설계Original Article Published on 2020-01-012022-08-13 Journal: Revista Brasileira de Terapia Intensiva [Category] 임상, [키워드] 7-point ordinal scale adjusted age and sex alleviate Analysis anti-inflammatory therapies Anti-inflammatory therapy applied approved Brazil C reactive protein Clinical outcome clinical outcomes clinical status combating consequence Coronavírus COVID-19 COVID-19 patient COVID-19 patients criteria D-dimer disease severity dissemination enrolment ethical committee Ethics ferritin IMPROVE inflammatory cascade inflammatory mediator Inflammatory response inhibiting institutional review board institutional review boards interleukin-6 International Lactate lactate dehydrogenase limit Local mediator moderate to severe multicentre National Odds ratio Open-label ordinal logistic regression Ordinal Scale outcome patients patients with COVID-19 patients with moderate primary endpoint Pro-inflammatory marker pro-inflammatory markers protocol Randomized Randomized controlled trial rationale required severe COVID-19 severity Standard of care Stratification Study protocol the disease The TOCIBRAS protocol TOCIBRAS Tocilizumab Tocilizumabe Trial trial testing variable [DOI] 10.5935/0103-507X.20200060 PMC 바로가기 [Article Type] Original Article
Causal relationships between obesity and the leading causes of death in women and men비만과 여성과 남성의 주요 사망 원인 사이의 인과 관계Research Article Published on 2019-10-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adjusted Affect Analysis association blood pressure BMI body mass body mass index cardiometabolic disease cardiometabolic diseases causal relationship causal relationships cause Chronic kidney disease chronic liver disease chronic obstructive chronic obstructive pulmonary disease chronic renal failure Cochran’s Q-test Coronary artery Coronary artery disease death diabete diabetes Diabetes Mellitus disease disease risk downstream Effect etiological Fatty liver fatty liver disease genetic data genetic risk score genetic variants glycemic GRS heart disease higher risk implicated implication increase increased risk indicate instrumental variable instrumental variables investigated involved Kidney disease lung cancer majority mediators men men and women mendelian randomization Mortality Non-alcoholic fatty liver disease non-communicable diseases obesity obstructive pulmonary disease preventative measure public health pulmonary disease renal renal failure risk smoking Still stroke traits type 2 diabete type 2 diabetes UK biobank waist waist-hip ratio Waist-hip-ratio WHR women [DOI] 10.1371/journal.pgen.1008405 PMC 바로가기 [Article Type] Research Article
The perceived effectiveness of MERS-CoV educational programs and knowledge transfer among primary healthcare workers: a cross-sectional surveyResearch Article Published on 2019-03-212022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] adjusted age calculated clinics Community confidence interval coronavirus country cross-sectional survey deviation dissemination education Effectiveness evaluated female FIVE foundation HCW HCWs healthcare healthcare worker highest hospital hospitals information knowledge Knowledge transfer less male males Mayo Clinic MERS MERS-CoV Middle East negative Nurses outbreak outcome Patient care patients Physicians positive Prevalence prevalent primary care Primary health respiratory syndrome coronavirus Result Sample Saudi Arabia supplementary material transfer were excluded [DOI] 10.1186/s12879-019-3898-2 PMC 바로가기 [Article Type] Research Article
The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases인간 질병에 대한 단백질 바이오마커에 대한 DNA 메틸화 및 유전적 변이의 상대적 기여도Research Article Published on 2017-09-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adjusted Affect allele alteration analyses analyzed association Biomarker Biomarkers Cancer cardiovascular disease cardiovascular diseases caused copy CXCL11 CXCL9 disease disease pathogenesis disease status disease-associated Diseases DNA methylation DNA methylation level DNA methylation levels driven by Effect effect size effect sizes effective environmental factor environmental factors Epigenetic Evidence expression expression patterns Factor Genes Genetic Genetic variant genetic variants Genetic variation Genome Genome-wide association study genomic position GWAS Human human disease human diseases IL-12 IL-18 Inflammation loci locus Modification MOST NLRC5 overlapped Pathogenesis performed phenotypic Protein risk smoking SNP SNPs trans unique Variation were measured while [DOI] 10.1371/journal.pgen.1007005 PMC 바로가기 [Article Type] Research Article
Safety and immunogenicity of a parenteral P2-VP8-P[8] subunit rotavirus vaccine in toddlers and infants in South Africa: a randomised, double-blind, placebo-controlled trial남아프리카 공화국의 유아 및 유아에 대한 비경구 P2-VP8-P[8] 서브유닛 로타바이러스 백신의 안전성 및 면역원성: 무작위, 이중 맹검, 위약 대조 시험Articles Published on 2017-05-052022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] 95% CI adjusted adverse event adverse events African approach assigned benefit block Block randomisation Cohort computer-generated different dose different doses dose dose-escalation doses double-blind eligible Endpoint enrolled finding FIVE followed by foundation Frequency funding geometric mean geometric mean titre geometric mean titres groups healthy highest HIV-uninfected homologous hospital IgA IgG IgG seroresponse immunogenic immunogenicity Infant Infants injection Injections Laboratory live oral rotavirus vaccines Local Melinda Gate Melinda Gates Mild neutralising antibody neutralising antibody seroresponse neutralising antibody seroresponses nine non-replicating rotavirus vaccine occurred offer oral rotavirus vaccine oral vaccines parent Parenteral parents participant Placebo placebo group placebo-controlled placebo-controlled trial primary immunogenicity randomisation randomised reaction receiving reduced Registered Research rotavirus rotavirus disease rotavirus vaccination rotavirus vaccine Safety safety analysis safety endpoint Serious Adverse Event Serious Adverse Events Serum IgA seroresponse Serum IgA seroresponses Seven severity South South Africa subunit Subunit vaccine systemic reaction systemic reactions the placebo group those receiving placebo Treatment Trial trivalent vaccination Vaccine was done was used [DOI] 10.1016/S1473-3099(17)30242-6 PMC 바로가기 [Article Type] Articles
Association between Severity of MERS-CoV Infection and Incubation PeriodExpedited Published on 2016-03-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] adjusted analyzed coronavirus death illness increase in Incubation Incubation period Infection laboratory-confirmed MERS-CoV Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus Patient Period reduction in respiratory syndrome coronavirus risk severity South Korea viruses [DOI] 10.3201/eid2203.151437 PMC 바로가기 [Article Type] Expedited
Daily consumption of ready-to-use peanut-based therapeutic food increased fat free mass, improved anemic status but has no impact on the zinc status of people living with HIV/AIDS: a randomized controlled trial바로 사용할 수 있는 땅콩 기반 치료 식품을 매일 섭취하면 무지방 질량이 증가하고 빈혈 상태가 개선되지만 HIV/AIDS 감염자의 아연 상태에는 영향을 미치지 않습니다. 무작위 대조 시험Research Article Published on 2016-01-042022-08-09 Journal: BMC Public Health [Category] 임상, [키워드] adjusted Admission affected AIDS Anemia anemic anemic status ART atomic absorption spectrometry Bio-Impedance Analysis Body body composition body fat body weight both groups clinical trial comparable Concentration conducted Control control group Controlled Controlled clinical trial CRP Daily daily recommended intake deficiency discharge energy fat Fat free mass fat-free mass food group hemoglobin HIV/AIDS Hospitalized Improving Individual dietary Infection iron Malnutrition measure muscle mass on admission patients percentage body fat plasma plasma zinc concentration PLWH positive Randomized controlled trial Randomly ready-to-use therapeutic food receive Recommended Dietary Allowances Registered remained Result Senegal severe malnutrition significantly standard hospital diet status sub-Saharan Africa the patient therapeutic Therapeutic food Treatment was determined was measured were measured Zinc zinc deficiency α1-AGP [DOI] 10.1186/s12889-015-2639-8 PMC 바로가기 [Article Type] Research Article
Findings from the SASA! Study: a cluster randomized controlled trial to assess the impact of a community mobilization intervention to prevent violence against women and reduce HIV risk in Kampala, UgandaSASA의 발견! 연구: 우간다 캄팔라에서 여성에 대한 폭력을 예방하고 HIV 위험을 줄이기 위한 지역사회 동원 개입의 영향을 평가하기 위한 클러스터 무작위 통제 시험Research Article Published on 2014-07-312022-08-09 Journal: BMC Medicine [Category] 임상, [키워드] 95% CI 95% confidence interval adjusted baseline Cluster Community Community mobilization conducted Controlled trial Cross-sectional surveys defined Drivers East Africa eight Evidence finding Follow-up Gender based violence greater HIV Impact evaluation impacts implementation intention-to-treat analysis Intervention Intimate partner violence men outcome physical post intervention Prevalence Prevent Primary outcome protocol public health random Random sample Randomized controlled trial receive reduce replicated responses Result risk risk ratio Sex significantly significantly lower Study protocol sub-Saharan Africa supplementary material Trial registration Uganda Violence Violence prevention while woman women [DOI] 10.1186/s12916-014-0122-5 PMC 바로가기 [Article Type] Research Article
Roles of TNF -α gene polymorphisms in the occurrence and progress of SARS-Cov infection: A case-control studyResearch Article Published on 2008-02-292022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] 95% CI acute respiratory syndrome adjusted Analysis association carried case-control study collected data compared conducted cured determine discharged fibrosis found Genetic polymorphism Genotype glucocorticoid Health care worker healthy controls Host genetic factor Infection interstitial locus Logistic lung Lung fibrosis manifested Necrosis not affect Occurrence PCR polymorphism prognosis of patient promoter region protective effect relationship Result risk risk factor role SARS patient SARS patients SARS-CoV infection Sequencing SNP susceptibility TNF TNF-α was used [DOI] 10.1186/1471-2334-8-27 PMC 바로가기 [Article Type] Research Article
Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003Research Article Published on 2004-09-062022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] 2003 3CLpro adjusted Analysis antigenic antigenic protein appear arising calculated Cell culture China Co-infection Complete Contact Culture cultured isolate Deletion different estimate FIVE found functional Gene Genes Genetic Genome greater group growth hotel human population human populations human tissue human-to-human transmission in vitro in vivo isolate isolates molecular Mutation mutation rate Non-synonymous mutation North nucleotide substitution ORF ORFs passage pathogen Patient per day polymerase Proteins related respiratory Result RNA virus SARS Coronavirus SARS-CoV selection pressure sequence sequenced severe Singapore Taiwan the epidemic the SARS epidemic tissue sample Transmission transmission patterns undergo Vero Cell viral genome was used whole genome sequence [DOI] 10.1186/1471-2334-4-32 PMC 바로가기 [Article Type] Research Article