SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism
Research Article
[키워드] acute lung injury
acute respiratory syndrome
affecting
alveolar inflammation
ARDS
Author
BALB/c mice
caused
cell proliferation
clinical disease
coronavirus
death
demonstrated
Dependent
died
Diffuse alveolar damage
ENhance
Epidemic
evaluated
highly pathogenic
I, II
independent
Infected
Infection
innate immune
innate immune response
Innate immunity
interferon
interferon signaling
knockout mice
lack
liver
Lung disease
Lung injury
Lung pathology
MA15
mechanism
mice
molecular mechanism
Mortality
Mouse models
other tissue
outcomes
Pathogenesis
Pathways
Post-infection
PROTECT
Protein
pulmonary fibrosis
pulmonary lesion
question
receptor
regulated
respiratory
respiratory virus
SARS Coronavirus
SARS pathogenesis
SARS-CoV
SARS-CoV infection
severe
severe disease
Signaling
spleen
Stat1
the epidemic
Type
type I
type III interferon
viral pathogenesis
virus
virus pathogenesis
virus titer
Virus-host interaction
viruses
weight loss
wildtype
[DOI] 10.1371/journal.ppat.1000849 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1000849 PMC 바로가기 [Article Type] Research Article