Odds ratio – Page 158 – Communicable Diseases Research

Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals

공통 변이체는 매우 작은 개체를 제외하고 분포 꼬리의 키에 대한 예측된 다유전자 효과를 보여줍니다

Research Article

Published on 2011-12-292022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a major allele Author average calculated chance classic cohorts common common disease common variants complex decrease determine discrepancy distribution Effect effect size Effects effort expectation expected explain explained extreme Factor found fraction Frequency Genetic Genetic variant Genetic variation Height Human genome implication include individual individuals less loci low frequency Odds ratio Odds ratios phenotype Phenotypes population-based cohort Predictive quantitative traits short stature show shown significantly stature tail trait traits variant variants Variation whole-exome sequencing whole-genome
[DOI] 10.1371/journal.pgen.1002439 PMC 바로가기 [Article Type] Research Article

Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease

대규모 유전자 중심 분석으로 관상동맥 질환에 대한 새로운 변종 식별

Research Article

Published on 2011-09-222022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] ABCG5 ABCG8 aetiology Affect allele Analysis array Artery Asians association association tests Author biochemical CAD candidate gene cardiovascular disease cellular characterized COL4A1 COL4A2 common variants complement conducted Control controls Coronary Coronary artery Coronary artery disease custom-designed array customised gene array CYP17A1 disease Effect European Europeans Evidence evidence of examined except for found Frequency function functional variant functional variants Gene Gene Expression Genes Genetic Genetic variant genome-wide association genotyped GWA heart disease help heterogeneity identify IL5 LIPA loci low frequency LPA majority mechanism not differ novel novel association novel associations Odds ratio Potential potential mechanism potential mechanisms replicate Replication reported risk risk factor South South Asian suggested supported susceptibility susceptibility loci target tested therapeutic interventions TRIB1 variant variants Vascular ZC3HC1
[DOI] 10.1371/journal.pgen.1002260 PMC 바로가기 [Article Type] Research Article

A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria

A −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성

Research Article

Published on 2011-05-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

[키워드] 95% confidence interval A allele a major activated affected allele Analysis Anemia Apoptosis applied assigned association Author carried Case-control caused CD69 Cell cell surface receptor cerebral malaria childhood children Community compared complex interplay complications Control Donor ENCODE Endemic Express expression FACS analysis FAS fatality found functional Genetic variant genetic variants genetics Health healthy individual help heterozygote homozygote homozygous Human Human genetics immune regulation immune response immune responses increased expression individual Infection investigated involved life-threatening locus lymphocyte Lymphocytes malaria molecule mononuclear cell mononuclear cells naïve nucleotide Occurrence Odds ratio outcome Pediatric case Peripheral blood Peripheral blood mononuclear cells phenotypic Plasmodium Plasmodium falciparum predisposition programmed cell death promoter promoter region proportion PROTECT Protective protective immune response Replication risk severe severe malaria significantly significantly higher Single nucleotide variant sub-Saharan Africa subgroup surface receptor susceptibility susceptible syndrome T-lymphocyte the disease Transmission dynamics variant West
[DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article

Epidemiologic Clues to SARS Origin in China

Research

Published on 2004-06-012022-10-31
Journal: Emerging Infectious Diseases [Category] Coronavirus,