Human Management of a Wild Plant Modulates the Evolutionary Dynamics of a Gene Determining Recessive Resistance to Virus Infection야생 식물의 인간 관리는 바이러스 감염에 대한 열성 내성을 결정하는 유전자의 진화 역학을 조절합니다Research Article Published on 2016-08-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles analysed Analysis assays Capsicum coding sequence cultivation Defense Determining Diseases Diversity Dynamics Effect electrostatic Evidence evidence of Evolution full-length functional gene encode Genetic variation genetics host-pathogen interaction host-pathogen interactions Human impairing Infection infection assay infection assays initiation factor Interaction involved loci management mapping Mutation Neutral no evidence of pathogen phenotypic Phylogeny physical plant plant virus plants Population populations Positive selection Potyvirus Proteins R genes recessive recognize resistance resistance gene resistance mutations Result resulting severity supported susceptibility translation initiation triggering Variation variety Viral viruses [DOI] 10.1371/journal.pgen.1006214 PMC 바로가기 [Article Type] Research Article
Prenatal exposure to Plasmodium falciparum increases frequency and shortens time from birth to first clinical malaria episodes during the first two years of life: prospective birth cohort study태아기 동안 Plasmodium falciparum에 노출되면 생후 2년 동안 첫 번째 임상 말라리아 에피소드까지의 시간 단축과 빈도가 증가합니다: 전향적 출생 코호트 연구Research Published on 2016-07-222024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] Clinical malaria episode Newborns Plasmodium falciparum Prenatal exposure susceptibility [DOI] 10.1186/s12936-016-1417-0 PMC 바로가기 [Article Type] Research
A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to NeuroinflammationT 세포 수용체 신호 분자 Vav1의 천연 변이체는 이펙터 T 세포 기능과 신경 염증에 대한 감수성을 모두 감소시킵니다Research Article Published on 2016-07-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation Affect alteration Antigen antigen receptor Autoimmune candidate gene CD4 T cell CD4 T cells changes in chromosome 9 Control cytokine cytokine production Cytokines Diseases effector effector T cell effector T cells FOXP3 function functions Genetic genetic study GM-CSF guanine highlight IFN-γ IL-17 immune system immunization Inflammatory cytokine Inflammatory cytokines intrinsic leads locus mechanism mice MOG molecule natural Neuroinflammation Non-synonymous normal enzymatic activity nucleotide peptide phenotype physiological polymorphism Polymorphisms proportion Quantitative receptor reduce reduced Regulatory T cell regulatory T cells Signaling susceptibility T cell T cell receptor T cells Th1/Th17 These data transducing Treg variant Vav1 [DOI] 10.1371/journal.pgen.1006185 PMC 바로가기 [Article Type] Research Article
Hepatitis B virus genotypes, expression quantitative trait loci for ZNRD1-AS1 and their interactions in hepatocellular carcinomaResearch Paper Published on 2016-07-122023-06-02 Journal: Oncotarget [Category] B형 간염, [키워드] eQTL HBV genotype HCC Interaction susceptibility [DOI] 10.18632/oncotarget.9854 PMC 바로가기 [Article Type] Research Paper
A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S방치된 항생제의 화학-유전체 검사에서 Kasugamycin 및 Blasticidin S의 불법적인 수송이 밝혀졌습니다Research Article Published on 2016-06-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] antibiotic Antibiotic resistance Antibiotics Antimicrobials approaches Bacteria Bacterial bacterial cell bacterial cells bacterial gene bacterial genes bacterial species biochemical blasticidin cells characterized compounds Critical determinant determinants determine disease E . coli Efficacy Escherichia coli Evidence Factor Fighting fire blight gene function Genetic genetic factors identify include investigated K-12 kasugamycin knowledge Loss mechanism microbe microbes Mutation Neglected open overlapping Pathogens peptide question reason reason for reduce Screen starting susceptibility targets these compound these compounds treat understanding [DOI] 10.1371/journal.pgen.1006124 PMC 바로가기 [Article Type] Research Article
Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan ChildrenlincRNA의 다형성이 케냐 어린이의 폐렴구균 균혈증 위험 2배와 연관Article Published on 2016-05-262022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, 폐렴구균 감염증, [키워드] 95% CI African Associate association Bacteremia bacteremia case subject bacteremia susceptibility bacterial bloodstream infection Cell cell type children conducted Control control subject control subjects death expression focus Frequency Genome-wide association study healthy Human genetics human infectious disease identification Infant Infectious disease Kenya lincRNA low frequency Neutrophils non-coding RNA occur pneumococcal bacteremia pneumococcal clearance polymorphism Polymorphisms recruited replicated Research Streptococcus pneumoniae sub-Saharan Africa subjects susceptibility susceptibility allele Wellcome Trust [DOI] 10.1016/j.ajhg.2016.03.025 PMC 바로가기 [Article Type] Article
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and HistonesCaenorhabditis elegans 단백질 FIC-1은 Heat-Shock 70 계열 단백질, 번역 연장 인자 및 히스톤을 공유적으로 수정하는 AMPylase입니다Research Article Published on 2016-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach ATP bacterial pathogen biochemical Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans connection consequence conserved core histone domain elegan elegans elongation elongation factors Endoplasmic reticulum Factor Factors family family members functional Heat shock heat shock protein heat-shock protein histone identify in vitro in vivo innate immune response Innate immunity modify novel nuclear ortholog P . aeruginosa pathogen phenotype post-translational modification Previous studies previous study Protein Proteins Pseudomonas aeruginosa sequence identity substrate susceptibility target protein target proteins three-dimensional structure translation unfolded protein response UPR [DOI] 10.1371/journal.pgen.1006023 PMC 바로가기 [Article Type] Research Article
Diminished COX-2/PGE 2 -Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial CellsResearch Article Published on 2016-04-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] A549 cell A549 cells addition Affect antiviral activity antiviral response Cell cellular chloride coronavirus 229E decrease decreased expression deficiency diminished downstream DPI dysregulated expression G6PD glucose-6-phosphate dehydrogenase homeostasis Impaired Infection Inflammatory response inhibitor MAPK NADPH NADPH oxidase NF-κB occurred oxidative stress PGE Phosphorylation provide reduced reducing Regulation response Signaling subunit susceptibility These data TNF-α transcriptional level Treatment tumor necrosis factor-α up-regulated viral infections viral replication was determined [DOI] 10.1371/journal.pone.0153462 PMC 바로가기 [Article Type] Research Article
Hepatitis B virus mutations, expression quantitative trait loci for PTPN 12, and their interactions in hepatocellular carcinomaArticle Published on 2016-04-142023-06-03 Journal: Cancer Medicine [Category] B형 간염, [키워드] PTPN12 eQTL HBV mutations HCC Interaction susceptibility [DOI] 10.1002/cam4.712 PMC 바로가기
Genotyping of Fusarium Isolates from Onychomycoses in Colombia: Detection of Two New Species Within the Fusarium solani Species Complex and In Vitro Antifungal Susceptibility Testing콜롬비아에서 손발톱진균증의 푸사리움 분리체 유전자형 분석: 푸사리움 솔라니 종 복합체 내 두 가지 새로운 종의 발견 및 시험관 내 항진균 감수성 테스트journal-article Published on 2016-04-012024-07-29 Journal: Mycopathologia [Category] 백선증, [키워드] haplotypes Pedicure Phylogenetic species susceptibility [DOI] 10.1007/s11046-016-9983-9 [Article Type] journal-article