Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: The CAPTURE study암 환자에서 예방 접종 후 SARS-COV-2 변이체에 대한 적응 면역 및 중화 항체 : 캡처 연구Clinical Trial Published on 2021-11-232022-08-13 Journal: Nature cancer [Category] MERS, SARS, 바이오마커, 변종, 임상, 진단, 치료기술, 치료제, [키워드] Adaptive immunity Administered administration anti-CD20 anti-CD20 treatment Antibody Response Antibody titers AZD1222 BNT162b2 Cancer cancer patient Cancer patients cancers capture CAPTURE study comparable Concordance COVID-19 COVID-19 immunity COVID-19 pandemic detectable dose evaluated Hematological malignancies Hematological malignancy implication individuals without cancer malignancies malignancy management median nAb response NAb responses NAbT Neutralising Antibodies neutralizing antibody Neutralizing antibody titer of BNT162b2 Patient patients Patients with cancer patients with haematological proportion prospective cohort study Prospective Study reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Seroconversion seroconversion rates solid cancer solid cancers T-cell Response T-cell responses undetectable vaccination Vaccine Vaccine-induced T-cell response Vaccine-induced T-cell responses Vaccines VOCs wildtype [DOI] 10.1038/s43018-021-00274-w PMC 바로가기 [Article Type] Clinical Trial
High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19Article Published on 2021-11-222022-10-04 Journal: Communications Biology [Category] MERS, SARS, 바이오마커, 변종, 진단, [키워드] Adaptive immunity analyzed antibody epitopes Antibody Response Antigen applied approach Bacterial binding coronavirus 2 Coronaviruses COVID-19 cross-reactive D614G Data mining data-driven Diagnostic markers disease severity dominant epitope effective vaccine elicit epitope epitope mapping Evolution of SARS-CoV-2 highlight humoral identify immune response in silico analysis infected patient large cohort Mild motif mutant Mutant SARS-CoV-2 neutralization activity organism other coronavirus Patient peptide platform proteome proteomes random reduced Region repertoire respiratory SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 epitope SARSCoV-2 serum samples severe disease specificity Spread Strains subject the vaccine Therapies therapy treat viral infection with COVID-19 [DOI] 10.1038/s42003-021-02835-2 PMC 바로가기 [Article Type] Article
Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination기도 항체는 COVID-19 중증도에 따라 나타나고 빠르게 감소하지만 SARS-CoV-2 백신 접종 후 다시 나타남Research Article Published on 2021-11-222022-09-12 Journal: JCI Insight [Category] MERS, SARS, 진단, [키워드] acute disease Adaptive immunity addition airway airways antibodies antibody Antibody Response Antibody responses asymptomatic infection boost clinically Cohort convalescence correlated COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patients COVID-19 severity declined disease elevated evaluated fatal disease highlighting IgA IgG IgG level immune response immune responses immunoglobulins immunology increase in individual individuals infected individual infected individuals Innate immunity mucosal naïve individuals neutralize Prevent prime prime and boost representing required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination significantly subset the antibody response understanding vaccination Vaccinations viral spread virus [DOI] 10.1172/jci.insight.151463 PMC 바로가기 [Article Type] Research Article
Severe Adaptive Immune Suppression May Be Why Patients With Severe COVID-19 Cannot Be Discharged From the ICU Even After Negative Viral Tests심각한 적응 면역 억제가 심각한 COVID-19 환자가 음성 바이러스 검사 후에도 ICU에서 퇴원할 수 없는 이유일 수 있음Observational Study Published on 2021-11-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 임상, [키워드] adaptive adaptive immune suppression Adaptive immunity addition analyzed Arm blood sample Blood samples caused Cell changes in classic collected COVID-19 COVID-19 pandemic Critically ill CTLA-4 decreased expression discharged enrolled exhibited expression gene expression profile Gene expression profiles Genes HLA molecules Host ICU immune cells Immune suppression Immunosuppression Inflammatory responses mechanism negative Patient patients PD-1 PD-L1 phenomenon SARS-CoV-2 secondary infections Sepsis severe disease Severe infection severely infected patient suppression Symptom Test transcriptome sequencing Viral [DOI] 10.3389/fimmu.2021.755579 PMC 바로가기 [Article Type] Observational Study
An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine AdjuvantsSARS-COV-2 감염에 대한 TLR의 반응에 대한 최근의 통찰력과 SARS-COV-2 백신 보조제로서 TLR 작용제의 잠재력에 대한 개요Review Published on 2021-11-182022-08-31 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity addition adjuvant adjuvants agonist approach chemokine coronavirus coronavirus disease COVID-19 COVID-19 vaccine COVID-19 vaccines Critical cytokine death Defense downstream dysregulated Efficacy ENhance focus Health Host host defense host innate immunity human disease immune responses Immune-mediated Immunity Immunopathogenesis initial innate immune response innate immune system Innate immunity insight Interaction invading pathogen invading pathogens pandemic pathogen pathogen-associated molecular pattern pathogen-associated molecular patterns Pathogens pathology Potential pro-inflammatory cytokine recent recognize respiratory response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shaping Signaling therapeutic TLR TLR agonist TLR agonists TLR response TLRs Toll-like receptor Toll-like receptors Vaccine [DOI] 10.3390/v13112302 PMC 바로가기 [Article Type] Review
Development of COVID-19 vaccine using a dual Toll-like receptor ligand liposome adjuvantBrief Communication Published on 2021-11-182022-10-04 Journal: NPJ Vaccines [Category] 진단, [키워드] Adaptive immunity adjuvants COVID-19 vaccine development elicited IgA immunization Ligand Liposome lung Lung injury mice neutralizing antibody receptor robust SARS-CoV-2 spike subunit systemic and local TLR Vaccine virus [DOI] 10.1038/s41541-021-00399-0 PMC 바로가기 [Article Type] Brief Communication
SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strainsSARS-CoV-2 B.1.1.7(알파) 및 B.1.351(베타) 변이체는 초기 균주와 구별되는 K18-hACE2 형질전환 마우스에서 병원성 패턴을 유도합니다Article Published on 2021-11-122022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] (alpha (Beta Adaptive immunity Alpha Antibody neutralization Antimicrobial responses B.1.1.7 B.1.351 caused combating COVID-19 cytokine D-dimer death hACE2 help hypoxia Immunity immunization induce Infection intramuscular K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice lesion less medical intervention mice Mutant SARS-CoV-2 neutralization titer organ pathogenic pathology Receptor binding domain reduced Reinfection resulting SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants Signaling strain Strains Transgenic mouse Transmissibility variant variants variants of concern Viral viral infection viral spike virulence VoC VOCs [DOI] 10.1038/s41467-021-26803-w PMC 바로가기 [Article Type] Article
COVID-19 in B Cell-Depleted Patients After Rituximab: A Diagnostic and Therapeutic Challenge리툭시 맙 후 B 세포 고갈 된 환자의 Covid-19 : 진단 및 치료 문제Review Published on 2021-11-032022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] adaptive Adaptive immunity Affect anti-CD20 anti-CD20 therapy anti-CD20 treatment anti-SARS-CoV-2 anti-SARS-CoV-2 monoclonal antibodies Antiviral treatment association Autoimmune disorders B cell B cell immunodeficiency B cell-depletion challenge Course COVID-19 deficiencies diagnostics disease Effect exposure to function hematologic hyperimmune convalescent plasma immune Immunity Immunotherapy Impact Interpretation involved long term malignancies Measures Musculoskeletal Protective rituximab SARS-CoV-2 SARS-COV-2 infection serological significantly Therapeutic approach therapeutic strategy vaccine responses variety [DOI] 10.3389/fimmu.2021.763412 PMC 바로가기 [Article Type] Review
A Modular Biomaterial Scaffold-Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS-CoV-2 Antigens모듈식 생체 재료 스캐폴드 기반 백신은 소단위 SARS-CoV-2 항원에 대한 내구성 있는 적응 면역을 유도합니다Article Published on 2021-11-012022-09-11 Journal: Advanced Healthcare Materials [Category] MERS, SARS, 변종, 진단, [키워드] activate adaptive Adaptive immunity antibodies antibody Antigen antigen-presenting cell antigen-presenting cells APCS biomaterial cellular colony-stimulating factor coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 vaccine cytotoxic cytotoxic T-cells described facilitate generate GM-CSF granulocyte granulocyte-macrophage colony-stimulating factor Humoral response immune responses Immunity in vitro injection lack mesoporous silica rods Monophosphoryl lipid A monophosphoryl lipid A (MPLA) MPLA pandemic Pathogens persistent platform poorly immunogenic Protein protein antigen RBD Receptor binding domain recombinant proteins recruit regimen robust rod Safe SARS-CoV-2 SARS-CoV-2 antigens SARS-CoV-2 variant SARS-CoV-2 viral silica Subunit vaccine subunit vaccines T-cells tested Toll-like receptor toll-like receptor 4 Vaccine vaccine platform Vaccines Viral viral neutralization [DOI] 10.1002/adhm.202101370 PMC 바로가기 [Article Type] Article
The Dynamic Immunological Parameter Landscape in Coronavirus Disease 2019 Patients With Different Outcomes다른 결과를 가진 코로나바이러스 질병 2019 환자의 동적 면역학적 매개변수 풍경Immunology Published on 2021-10-292022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] adaptive Adaptive immunity CD14 CD16 CD4 CD45RO CD8 Cell characterized cluster analysis coronavirus disease COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients cutoff value Deceased decrease demonstrated dendritic cell dynamic early phase enrolled expression highlighting HLA-DR host immunity Humoral immunity IgG IL-6 Immunity immunological immunological parameters Inflammatory marker Innate immunity involved landscape lymphocyte Mild Monocytes neutrophil Neutrophils NK cells objective outcome Patient patients Plasma cell Platelet Prognosis proinflammatory monocyte rapid increase reported restored Result severe patients sustained symptom onset systemically T cell T cells these cell [DOI] 10.3389/fimmu.2021.697622 PMC 바로가기 [Article Type] Immunology