Receptor-Loaded Virion Endangers GPCR Signaling: Mechanistic Exploration of SARS-CoV-2 Infections and Pharmacological Implications수용체가 장착된 Virion은 GPCR 신호 전달을 위험에 빠뜨립니다: SARS-CoV-2 감염 및 약리학적 의미의 기계적 탐색Review Published on 2021-10-112022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 치료제, [키워드] ACE2 ACE2 receptor alleviate antibody Antibody therapy arrestin binding Brain Cell cell junction cellular response COVID-19 demonstrated disrupting Disruption distribution drug Drug development E protein ENhance exploration GPCR signaling hematogenous host cells impair Infection interact Interaction intestine Invasion kidney Loss of Smell loss of smell and taste lung Lungs membrane motif multiorgan injury multiple organs NRP1 other organ other organs PALS1 pathogenic PDZ interaction penetration Protein receptor required respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections susceptible Taste therapeutic strategy therapy tissue Viral viral cell entry viral endocytosis viral invasion virion virtue ZO-1 [DOI] 10.3390/ijms222010963 PMC 바로가기 [Article Type] Review
Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity Research Published on 2021-10-112022-10-05 Journal: Nature [Category] SARS, 변종, [키워드] Affect alleviate analysed Analysis anti-SARS-CoV-2 antibody antibody Antibody titre B.1.351 B.1.617.2 booster both group circulating SARS-CoV-2 variant comparable Comprehensive E484K example Humoral immunity Impact in vitro individual Infection isolate L452R Lineage marker mRNA mRNA vaccine Mutation neutralization neutralization capacity Neutralizing Neutralizing activity nucleocapsid P.1 peptide plasma reached reduction reduction in response retained SARS-CoV-2 SARS-CoV-2 variant specific mutation sustained T cell activation T cell response uninfected vaccination Vaccine vaccine dose vaccine doses Vaccine-induced immunity variant variants while [DOI] 10.1038/s41586-021-04085-y [Article Type] Research
Teaching and Practicing Cognitive-Behavioral and Mindfulness Skills in a Web-Based Platform among Older Adults through the COVID-19 Pandemic: A Pilot Randomized Controlled TrialRandomized Controlled Trial Published on 2021-10-092022-10-04 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 임상, [키워드] Administered alleviate ANOVA baseline benefit change clinically cognitive Community control group Controlled COVID-19 COVID-19 pandemic Depression Effect Effectiveness Evidence female Follow-up help impacts Intervention intervention group loneliness measure mental health mindfulness Older online sessions outbreak pandemic post-intervention promote provided Randomized Randomized controlled trial reduce reductions in Seven significantly skill Social support statistically statistically significant Support Teaching web-based group intervention [DOI] 10.3390/ijerph182010563 PMC 바로가기 [Article Type] Randomized Controlled Trial
Vaccination of older adults: Influenza, pneumococcal disease, herpes zoster, COVID-19 and beyondReview Published on 2021-10-092022-10-30 Journal: Immunity & Ageing : I & A [Category] COVID-19, [키워드] addition adjuvant Adults age alleviate Antigen Care caused chronic disease Clinical data COVID-19 develop disease dose Efficacy elderly frailty group Health healthy herpes zoster high risk highlight IMPROVE Infection Infectious disease Influenza limitation morbidity and mortality Older Older age overcome Pathogens pneumococcal pneumococcal disease Preserving Prevalence prevention Quality of life Research SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 vaccine severe disease severity Streptococcus pneumoniae vaccination Vaccine Vaccines [DOI] 10.1186/s12979-021-00249-6 PMC 바로가기 [Article Type] Review
Rapid COVID-19 Molecular Diagnostic System Using Virus Enrichment PlatformArticle Published on 2021-10-062022-10-27 Journal: Biosensors [Category] COVID-19, [키워드] Accuracy acute respiratory syndrome alleviate amplify caused Community coronavirus coronavirus disease COVID-19 detect diagnosis of COVID-19 diagnostic diagnostic test enrichment fluoride healthcare hydrophilic Infection isothermal amplification lateral flow molecular molecular diagnostics nasopharyngeal nucleic acid amplification pandemic pandemic era platform Prevent public health Rapid rapid diagnostics reduce reverse transcription RNA RNA extraction robust sample preparation SARS-CoV-2 specimens Spread System therapeutic intervention virus virus enrichment [DOI] 10.3390/bios11100373 PMC 바로가기 [Article Type] Article
Rapid COVID-19 Molecular Diagnostic System Using Virus Enrichment Platform바이러스 농축 플랫폼을 사용한 빠른 CovID-19 분자 진단 시스템Article Published on 2021-10-062022-09-01 Journal: Biosensors [Category] 진단, 치료기술, 치료제, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus alleviate amplify caused clinic Community coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect diagnosis of COVID-19 diagnostic diagnostic test diagnostic tests enrichment fluoride hand healthcare hydrophilic Infection isothermal amplification LAMP lateral flow Loop-mediated isothermal amplification medical staff molecular molecular diagnostics myriad nasopharyngeal nucleic acid nucleic acid amplification pandemic pandemic era platform Prevent public health Rapid rapid diagnostics reduce respiratory reverse transcription RNA RNA extraction robust sample preparation SARS-CoV-2 severe acute respiratory syndrome Coronavirus specimens Spread System therapeutic intervention virus virus enrichment viruses [DOI] 10.3390/bios11100373 PMC 바로가기 [Article Type] Article
Rapid COVID-19 Molecular Diagnostic System Using Virus Enrichment PlatformArticle Published on 2021-10-062022-10-27 Journal: Biosensors [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] Accuracy acute respiratory syndrome alleviate amplify caused Community coronavirus coronavirus disease COVID-19 detect diagnosis of COVID-19 diagnostic diagnostic test enrichment fluoride healthcare hydrophilic Infection isothermal amplification lateral flow molecular molecular diagnostics nasopharyngeal nucleic acid amplification pandemic pandemic era platform Prevent public health Rapid rapid diagnostics reduce reverse transcription RNA RNA extraction robust sample preparation SARS-CoV-2 specimens Spread System therapeutic intervention virus virus enrichment [DOI] 10.3390/bios11100373 PMC 바로가기 [Article Type] Article
Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agentsEphedra Sinica STAPF의 활성 성분은 ACE2와 SARS-COV-2 RBD 사이의 상호 작용을 방해합니다 : 강력한 COVID-19 치료제Article Published on 2021-10-052022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 치료제, [키워드] 293T-ACE2 4-hydroxy-6-methoxyquinoline-2-carboxylic acid (PubChem CID: 22017520) 4-hydroxyquinoline-2-carboxylic acid (PubChem CID: 3845) 4,6-dihydroxyquinoline-2-carboxylic acid (PubChem CID: 440752) ACE2 ACE2-RBD activity alleviate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Asia Asthma binding domain Calu calu-3 cells carboxylic acid carried cells Chinese Cold component Compound compounds cough COVID-19 COVID-19 therapeutic agent Deterioration disrupt disrupting docking domain effort ephedra Ephedra sinica Ethanol HPLC hydrogen Hydrogen bond hydroxy indicated inhibit inhibit SARS-CoV-2 inhibiting Inhibition assays inhibitory activity Interaction Isolation knock-out Lung diseases material mechanism molecular docking NMR observé potent potential therapeutic agent potential therapeutic agents PPI PPI inhibitor Prevent protein-protein interaction provided pseudoviruses PubChem quinoline Quinoline-2-carboxylic acid S protein SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus SARS-CoV-2 virus infection Spike protein SPR Structure structures suggested surface plasmon surface plasmon resonance Symptom TCM the SARS-CoV-2 therapeutic agents these compound these compounds Traditional Chinese medicine treat viropexis virus infection were used [DOI] 10.1016/j.jep.2021.114303 PMC 바로가기 [Article Type] Article
Neuropsychiatric Ramifications of COVID-19: Short-Chain Fatty Acid Deficiency and Disturbance of Microbiota-Gut-Brain Axis SignalingReview Article Published on 2021-10-052022-10-27 Journal: BioMed Research International [Category] [키워드] accompanied ACE-2 acid alleviate Altered Anti-inflammatory anti-inflammatory function axis Bacteria binding Brain changes in characterized commensal bacteria Complication components contribute COVID-19 COVID-19 patient Critical decrease deficiency described diagnostic disorders disturbance evaluate fatty favor fecal fiber gastrointestinal symptoms Gut gut microbiota gut microbiota composition implicated increase in Inflammation metabolite microbial Neurological disorder Neuropsychiatric Pathogens Prevent producing proinflammatory Psychiatric ramification receptor recommendation Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors SCFA signaling pathway supported systemic inflammation Transport turn viral presence [DOI] 10.1155/2021/7880448 PMC 바로가기 [Article Type] Review Article
Neuropsychiatric Ramifications of COVID-19: Short-Chain Fatty Acid Deficiency and Disturbance of Microbiota-Gut-Brain Axis SignalingReview Article Published on 2021-10-052022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, SARS, [키워드] accompanied ACE-2 acid alleviate Altered Anti-inflammatory anti-inflammatory function axis Bacteria binding Brain changes in characterized commensal bacteria Complication components contribute COVID-19 COVID-19 patient Critical decrease deficiency described diagnostic disorders disturbance evaluate fatty favor fecal fiber gastrointestinal symptoms Gut gut microbiota gut microbiota composition implicated increase in Inflammation metabolite microbial Neurological disorder Neuropsychiatric Pathogens Prevent producing proinflammatory Psychiatric ramification receptor recommendation Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors SCFA signaling pathway supported systemic inflammation Transport turn viral presence [DOI] 10.1155/2021/7880448 PMC 바로가기 [Article Type] Review Article