The Plasmodium falciparum eIK1 kinase (PfeIK1) is central for melatonin synchronization in the human malaria parasite. Melatotosil blocks melatonin action on parasite cell cycle플라스모디움 팔시파룸 eIK1 키나제(PfeIK1)는 인간 말라리아 기생충에서 멜라토닌 동기화에 중심적인 역할을 합니다. 멜라토실은 기생충 세포 주기에 대한 멜라토닌 작용을 차단합니다.Original Article Published on 2020-08-072024-08-26 Journal: Journal of Pineal Research [Category] 말라리아, [키워드] antimalarial genetic calcium sensor melatonin Plasmodium falciparum synthetic indol [DOI] 10.1111/jpi.12685 PMC 바로가기 [Article Type] Original Article
Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected catsResearch Article Published on 2020-08-052022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Accuracy antimalarial Antiviral average binding calicivirus clinical trial clinically coefficient Concentration coronavirus demonstrated detect dialysis dosing regimens expressed in vitro in vivo infections inhibit investigated limit plasma plasma concentration plasma protein Plasma Protein Binding Population Precision proportion Proteins quantification reported Standard deviation Variation [DOI] 10.1371/journal.pone.0236754 PMC 바로가기 [Article Type] Research Article
Antimalarial diterpenoids from Vitex rotundifolia: Isolation, structure elucidation, and in vitro antiplasmodial activityArticle Published on 2020-07-312024-09-09 Journal: Bioorg Chem [Category] 말라리아, [키워드] antimalarial Diterpenoids Isolation structure elucidation Vitex rotundifolia. PMC 바로가기
Cardiovascular Considerations of Experimental Hydroxychloroquine Therapy on Patients Diagnosed With COVID-19: A Case Series ReviewCardiology Published on 2020-07-122022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome adverse effect antimalarial ARDS Asymptomatic benefit bradycardia cardiovascular caused Community coronavirus coronavirus disease COVID 19 COVID-19 Efficacy Evidence HCQ heterogeneous nature Hydroxychloroquine lack medication pandemic Patient prolonged qt Randomized controlled trials review risk-benefit SARS-CoV-2 Sery Side effect Symptom syndrome the disease therapeutic therapeutic effect virulence while [DOI] 10.7759/cureus.9151 PMC 바로가기 [Article Type] Cardiology
Cytokine Storm in COVID-19: The Current Evidence and Treatment StrategiesImmunology Published on 2020-07-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] “cytokine storm” acute respiratory syndrome antimalarial antimalarial agents approach cause caused cells Concentration contribute coronavirus coronavirus disease Corticosteroids COVID-19 COVID-19 patients current cytokine Cytokine storm death effective Evidence IL-6 IL-6 inhibitor immunoregulation indicate induce infiltration Intravenous immunoglobulin lung tissue Lymphocytes Macrophage Mortality outbreak pathogen pathologic feature patients with COVID-19 poor prognosis pro-inflammatory pro-inflammatory cytokines programmed cell death Protein Safe severely ill patient storm Strategy the cytokine storm Tocilizumab Treatment strategies [DOI] 10.3389/fimmu.2020.01708 PMC 바로가기 [Article Type] Immunology
The risk of QTc-interval prolongation in COVID-19 patients treated with chloroquineOriginal Article Published on 2020-07-092022-10-30 Journal: Netherlands Heart Journal [Category] COVID-19, [키워드] adjusted Analysis antimalarial Chloroquine coronavirus disease COVID-19 COVID-19 patient cumulative dose ECG Electrocardiography evaluate gradually increased hospitalised increase increase in infection with COVID-19 inhibit Interpretation medication objective Patient peak plasma concentration performed QT interval QTc interval Result risk SARS-CoV‑2 infection treated Treatment viral replication was performed [DOI] 10.1007/s12471-020-01462-6 PMC 바로가기 [Article Type] Original Article
BCG vaccination policy and preventive chloroquine usage: do they have an impact on COVID-19 pandemic?Article Published on 2020-07-082022-10-04 Journal: Cell Death & Disease [Category] SARS, 임상, [키워드] acute respiratory syndrome affected African Analysis antimalarial Bacillus BCG BCG vaccination caused Chloroquine coronavirus 2 Coronavirus disease 2019 country COVID-19 COVID-19 case COVID-19 disease COVID-19 patients Epidemiology hypothese immunization incidence inverse correlation less malaria Mortality pandemic performed Plasmodium positive Preclinical research reported SARS-CoV-2 severity shown the disease treat vaccination widespread World Health Organization [DOI] 10.1038/s41419-020-2720-9 PMC 바로가기 [Article Type] Article
Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responses하이드록시클로로퀸과 아지스로마이신의 병용 치료는 항암 면역 반응의 치료 유도와 양립 가능합니다.Article Published on 2020-07-082022-09-11 Journal: Oncoimmunology [Category] SARS, 바이오마커, 비임상, 신약개발, 임상, [키워드] administration Affect antibiotic anticancer antimalarial antimalarial drug appear autophagic flux AZI Azithromycin blockade body weight breath Campus Cancer Cancer patients cancers cisplatin clinical trial Combination combination therapy COVID-19 crizotinib curative dose doses Gustave Roussy HCQ Hydroxychloroquine immune immune checkpoint immune response immune responses immunogenic cell death Immunotherapy indicated inducer interfere investigated lung cancer mice not affect oxaliplatin PD-1 preclinical study reduction in regimen SARS-CoV-2 therapeutic treated Treatment Tumor tumor growth utility [DOI] 10.1080/2162402X.2020.1789284 PMC 바로가기 [Article Type] Article
Pharmacotherapy in COVID-19; A narrative review for emergency providersReview article Published on 2020-07-012022-10-05 Journal: The American journal of emergency medicine [Category] SARS, 치료제, [키워드] ACE ACE inhibitor active against acute respiratory distress angiotensin receptor blocker antagonist antimalarial Antiviral antivirals ARB ARBs ARDS Care Chloroquine Clinical guidelines clinical trial Combination combination treatment conducted convalescent plasma COVID 19 COVID-19 COVID-19 pandemic Critical CRS current current therapy Cytokine release syndrome develop disease drug Effectiveness Efficacy enzyme established therapy evaluated Evidence Favipiravir Fever Health Healthcare provider Hydroxychloroquine IL-6 information inhibitors lack literature review non-steroidal anti-inflammatory drug NSAIDS objective off-label pandemic Patient patients with moderate pharmacotherapy potential therapies professionals recommendation Remdesivir resource SARS-CoV-2 Septic shock syndrome systematic reviews therapeutic drug therapy Transmission Treatment treatment guidelines Trial [DOI] 10.1016/j.ajem.2020.04.035 [Article Type] Review article
Covid-19: current knowledge, disease potential, prevention and clinical advancesArticle Published on 2020-06-212022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] Administered antimalarial antiviral drug antivirals chemotherapeutic agent China clinically COVID-19 COVID-19 infection COVID-19 outbreak Diagnosis disease drug economic growth Epidemiology financial crisis Health care system Infection Infectious disease knowledge mortality rate outbreak regimen the patient transmission rate (Ro) Treatment Vaccine Vaccine development Vaccines viral disease Wuhan [DOI] 10.3906/biy-2005-29 PMC 바로가기 [Article Type] Article