Barriers to scaling up hepatitis C treatment in Malaysia: a qualitative study with key stakeholders말레이시아에서 C 형 간염 치료를 확장하는 데 장애 : 주요 이해 관계자와의 질적 연구Research Published on 2022-02-212022-09-10 Journal: BMC Public Health [Category] COVID19(2023년), Fulltext, MERS, SARS, 치료제, [키워드] acceptability Antiviral agents barrier Care care providers civil society conducted coordinating coronavirus disease Coronavirus disease 2019 Coverage COVID-19 Data collection direct-acting antiviral disease door HCV Health Health Service Health services accessibility Hepatitis hepatitis C hepatitis C virus implementation individuals knowledge Laboratory Laboratory tests Limited Malaysia movement National opens organization outbreak overcome Perspective public health Result shifting supply suppress thematic analysis translated Treatment treatment initiation while [DOI] 10.1186/s12889-022-12786-w PMC 바로가기 [Article Type] Research
Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 InfectionResearch Article Published on 2022-02-152022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] N-glycosylation Ablation acute respiratory syndrome Antiviral agents B.1.1.7 B.1.351 B.1.617.2 Beta binding block Cell conditions coronavirus Coronavirus-2 COVID-19 Critical Delta FDA-approved drugs Gamma glycan glycosylate glycosylation Host host cell host immunity host receptor immunotherapies Infection inhibition inhibitors Invasion investigated modulate N -glycosylation P.1 pathway predicted produced Protein reduced RNA interference SARS-CoV-2 SARS-CoV-2 N Spike proteins Spread Treatment Vaccine variant viral infection virion [DOI] 10.1128/mbio.03718-21 PMC 바로가기 [Article Type] Research Article
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern경구 프로테아제 억제제(PF-07321332)는 우려되는 SARS-CoV-2 변종 감염으로부터 시리아 햄스터를 보호합니다Article Published on 2022-02-152022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] 3CLpro Air-liquid interface Alpha Alpha variant animals Anti-viral Antiviral Antiviral agents B.1.351 B.1.617.2 Beta clinical development clinical trials dosed epithelial cell epithelial cells Evidence evidence of golden hamster golden hamsters hamster in vitro activity Infection infection with SARS-CoV-2 inhibitor intranasal MPro PF-07321332 Pfizer prevented primary human airway Primary human airway epithelial cells protease Protease inhibitor PROTECT reduced Replication SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selective Syrian Golden hamsters target Transmission Treatment variant variants of concern Viral viral replication [DOI] 10.1038/s41467-022-28354-0 PMC 바로가기 [Article Type] Article
Antiviral Activities of Algal-Based Sulfated Polysaccharides조류계 황산다당류의 항바이러스 활성Review Published on 2022-02-092022-09-10 Journal: Molecules [Category] COVID19(2023년), MERS, SARS, 변종, 치료제, [키워드] activity Alpha Antiviral antiviral agent Antiviral agents Beta carrageenan COVID-19 pandemic Culture Delta effective Efficacy feature Gamma highlight human coronavirus include Isolation macro macroalgae marine plants microalgae nasal Nasal spray offer omicron Omicron variants patients plants Probability provide Safe social distancing sulfated polysaccharide sulfated polysaccharides Toxicity Vaccine development variants of SARS-CoV-2 viral disease [DOI] 10.3390/molecules27041178 PMC 바로가기 [Article Type] Review
A new screening system for entry inhibitors based on cell-to-cell transmitted syncytia formation mediated by self-propagating hybrid VEEV-SARS-CoV-2 repliconCoronaviruses Published on 2022-02-042022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] addition antiserum Antiviral agents biosafety BSL-2 laboratory BSL-3 facility Cell COVID-19 Critical dose-dependent Entry inhibitor entry inhibitors events Evidence GFP Increasing inhibitor inhibitors live SARS-CoV-2 pathway performed positive Protein reporter vector responsible SARS-CoV-2 seeking Severe case shown spike Syncytia syncytia formation syncytium formation the S protein Transmission transmission rate transmitted Treatment VEEV Venezuelan equine encephalitis viral spike virus [DOI] 10.1080/22221751.2022.2030198 PMC 바로가기 [Article Type] Coronaviruses
Pregnancy outcomes for pregnant women with chronic hepatitis B exposing to entecavir or adefovir dipivoxil therapy before or in early pregnancyArticle Published on 2022-02-012023-06-13 Journal: The journal of maternal-fetal & neonatal medicine [Category] B형 간염, [키워드] Antiviral agents Chronic Hepatitis B Infant Pregnancy pregnancy complications [DOI] 10.1080/14767058.2020.1723540
Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3)새로운 SARS-CoV-2 항바이러스제 시험을 위한 국제, 다군, 다단계 플랫폼 마스터 프로토콜의 설계 및 구현: COVID-19 입원 환자를 위한 치료제(TICO/ACTIV-3)Article Published on 2022-02-012022-09-11 Journal: Clinical Trials (London, England) [Category] 임상, 치료제, [키워드] adults hospitalized agent Antiviral Antiviral agents applicability approach approaches approval clinical trial collaboration Consent Forms COVID-19 Data collection drug effective therapy Efficacy enrolled Evidence evidence of expected facilitate feature FIVE food Food and Drug Administration forms harmonization hospitalized patient hospitalized patients implementation infection rate infection rates information initiated Inpatient Inpatients International matching placebo multi-arm multi-arm multi-stage Other outbreak overcome participant participated Patient Placebo platform platform trials. potential therapeutic agent potential therapeutic agents protocol provided Randomized Rapid recruitment Regulatory required robust safety evaluation Safety Monitoring Board safety profile Sample size SARS-CoV-2 Stage subsequent target population therapeutic agent Therapeutics Trial trials with COVID-19 [DOI] 10.1177/17407745211049829 PMC 바로가기 [Article Type] Article
Kinetics of hepatitis B surface antigen in pregnant women with and without tenofovir disoproxil fumarateArticle Published on 2022-02-012023-06-11 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] Antiviral agents Hepatitis B virus infectious disease transmission maternal-foetal relations Pregnancy [DOI] 10.1111/jvh.13628
H84T BanLec has broad spectrum antiviral activity against human herpesviruses in cells, skin, and miceArticle Published on 2022-01-312023-05-31 Journal: Scientific Reports [Category] Fulltext, 두창, 수두, 홍역, [키워드] Antiviral agents Herpes virus [DOI] 10.1038/s41598-022-05580-6 PMC 바로가기 [Article Type] Article
Rapid determination of acyclovir, its main metabolite 9‐carboxymethoxymethylguanine, ganciclovir, and penciclovir in human serum using LC–MS/MSResearch Article Published on 2022-01-282024-09-04 Journal: Biomedical chromatography : BMC [Category] 대상포진, [키워드] Antiviral agents LC–MS/MS serum analysis Therapeutic Drug Monitoring validation [DOI] 10.1002/bmc.5315 PMC 바로가기 [Article Type] Research Article