Working Hypothesis for Glucose Metabolism and SARS-CoV-2 Replication: Interplay Between the Hexosamine Pathway and Interferon RF5 Triggering Hyperinflammation. Role of BCG Vaccine?Endocrinology Published on 2020-07-072022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS, [키워드] BCG Cytokine storm glucose metabolism HB pathway IRF5 role SARS-CoV-2 working [DOI] 10.3389/fendo.2020.00514 PMC 바로가기 [Article Type] Endocrinology
A cytokine super cyclone in COVID-19 patients with risk factors: the therapeutic potential of BCG immunizationArticle Published on 2020-07-012023-06-15 Journal: Cytokine & growth factor reviews [Category] MERS, SARS, [키워드] ACE2, angiotensin converting enzyme 2 ALI, Acute Lung Injury ARDS, acute respiratory distress syndrome BADAS, BCG vaccine for health care workers as defense against COVID 19 BALF, bronchoalveolar lavage fluid BCG BCG-CORONA, reducing health care workers absenteeism in COVID-19 pandemic by enhanced trained immune responses through bacillus calmette-guérin vaccination, a randomized controlled trial BCG, bacillus calmette- guérin bFGF, basic fibroblast growth factor BRACE, BCG vaccination to reduce the impact of COVID-19 in healthcare workers following coronavirus exposure CCL, chemokine (C-C motif) ligand co-morbidity COPD, Chronic obstructive pulmonary disease coronavirus COVID-19, Coronavirus disease 2019 COVID-19(SARS Cov2) CXCL, C-X-C motif chemokine cytokine DPP4, dipeptidyl peptidase 4 G-CSF/GCSF, granulocyte-colony stimulating factor GDM, gestational diabetes mellitus GM-CSF, granulocyte-macrophage colony-stimulating factor Growth factors HCoV, human coronavirus IFN, interferon IL-1RA, interleukin-1 receptor antagonist IL, interleukin IP-10, IFN-γ-inducible protein-10 MCP-1, monocyte Chemoattractant Protein-1 MERS-CoV, Middle East respiratory syndrome coronavirus MIG, Monokine induced by gamma interferon MIP, macrophage inflammatory protein NKT, natural killer T cells PDGF, platelet-derived growth factor RANTES, regulated on activation, normal T cell expressed and secreted RNA, Ribonucleic acid SARS-CoV, severe acute respiratory syndrome coronavirus T2DM, type2 diabetes TGF-β, transforming growth factor-β Th, T helper TMPRSS2, Transmembrane Protease Serine 2 TNF, Tumor Necrosis Factor VEGF, Vascular endothelial growth factor [DOI] 10.1016/j.cytogfr.2020.06.014 PMC 바로가기 [Article Type] Article
The role of the urologist, BCG vaccine administration, and SARS‐CoV‐2: An overviewReview Published on 2020-06-222022-10-28 Journal: Bjui Compass [Category] COVID-19, [키워드] acute respiratory syndrome adaptive administration Bacillus Calmette-Guérin BCG BCG vaccination Case fatality rate clinical condition clinical trial clinics contribute coronavirus disease country COVID-19 COVID‐19 evaluate Evidence highlighting immune priming immunized Infection material morbidity objective pandemic Population potential mechanism PROTECT randomized clinical trial Research Result resulting SARS-CoV-2 SARS‐CoV‐2 severity Support translational vaccine administration [DOI] 10.1002/bco2.21 PMC 바로가기 [Article Type] Review
Could an Unrelated Live Attenuated Vaccine Serve as a Preventive Measure To Dampen Septic Inflammation Associated with COVID-19 Infection?Opinion/Hypothesis Published on 2020-06-192022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] administration BCG clinical trial contraindication coronavirus disease country COVID-19 COVID-19 case COVID-19 pandemic effective Evidence Health care worker high-risk population host response individual Inflammation innate immune cell lethal infection Live attenuated vaccine Live attenuated vaccines Lung inflammation measure MMR mumps Mycobacterium bovis myeloid-derived suppressor cells nonspecific Sepsis septic subsequent infections target pathogen the vaccine trained innate immunity Vaccine with COVID-19 [DOI] 10.1128/mBio.00907-20 PMC 바로가기 [Article Type] Opinion/Hypothesis
COVID-19 Clinical ResearchArticle Published on 2020-06-072022-10-29 Journal: Journal of cellular signaling [Category] COVID-19, [키워드] Area BCG children Clinical research clinical study clinical trial convalescent plasma COVID-19 COVID-19 pandemic Cytokine storm drug Efficacy effort expected expert health systems immunomodulatory Immunomodulatory agent Immunosuppression International National oncology pandemic plasma Registered Research researcher Result SARS-CoV-2 searched therapy Treatment trials triggered USA Vaccine Vaccines volunteers website while [DOI] 10.33696/Signaling.1.006 PMC 바로가기 [Article Type] Article
Two Randomized Controlled Trials of Bacillus Calmette-Guérin Vaccination to reduce absenteeism among health care workers and hospital admission by elderly persons during the COVID-19 pandemic: A structured summary of the study protocols for two randomised controlled trialsLetter Published on 2020-06-052022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 ambulance service assistant Bacillus BCG BCG vaccination BCG-vaccine blinded Care Community Controlled COVID-19 COVID-19 infection COVID-19 pandemic cumulative Denmark dissemination elderly element facilitate HCW HCWs Health care Health care worker Health-care workers hospital Hospital admission hospitals incidence Intervention intervention group investigators Medicine NaCl Netherlands number objective outcome outcome assessor parallel group participant Patient physician Placebo placebo group placebo-controlled protocol randomised randomised controlled trial Randomized randomized trial recruitment reduce Registered registry Research Sample size status stratified Study protocol the placebo group Trial vaccination Vaccine website [DOI] 10.1186/s13063-020-04389-w PMC 바로가기 [Article Type] Letter
Vaccines and Drug Therapeutics to Lock Down Novel Coronavirus Disease 2019 (COVID-19): A Systematic Review of Clinical TrialsInternal Medicine Published on 2020-05-282022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 2019 novel coronavirus Antiviral approved BCG candidate cellular therapy Chinese Chloroquine clinical clinical trial Combination Compound conducted COVID 19 COVID-19 database deaths drug drug combination drug therapeutics effective healthcare ICTRP Infection information lock majority medication novel novel coronavirus disease observational study pandemic Phase I phase III trial registry responsible review sars-cov-2 (severe acute respiratory syndrome coronavirus -2) Stage tested therapeutic agent Therapeutics therapy Treatment treatment choices Trial Vaccine vaccine candidate Vaccines viral infection WHO [DOI] 10.7759/cureus.8342 PMC 바로가기 [Article Type] Internal Medicine
Is BCG vaccination causally related to reduced COVID‐19 mortality?Commentary Published on 2020-05-262022-11-01 Journal: EMBO Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] absence Administered adopted BCG BCG vaccination Case fatality rate coronavirus country COVID‐19 death Denmark eight groups immunology incidence mandatory Microbiology, Virology & Host Pathogen Interaction Miller Mortality National pandemic question raise reduced resource S&S: Ethics SARS‐CoV‐2 Seven shown Sickness strain widespread [DOI] 10.15252/emmm.202012661 PMC 바로가기 [Article Type] Commentary
Bacillus Calmette Guérin (BCG) vaccination use in the fight against COVID-19 – what’s old is new again?Commentary Published on 2020-05-142022-10-31 Journal: Future Oncology [Category] Coronavirus, MERS, SARS, [키워드] Bacillus BCG bcg vaccine clinical trials coronavirus COVID-19 Immunotherapy Mycobacterium bovis vaccination [DOI] 10.2217/fon-2020-0381 PMC 바로가기 [Article Type] Commentary
Drug repurposing against COVID-19: focus on anticancer agentsReview Published on 2020-05-122022-10-29 Journal: Journal of Experimental & Clinical Cancer Research : CR [Category] COVID-19, MERS, SARS, [키워드] anticancer anticancer drugs BCG Body boost Cancer cancer cell Cancer cells Cancer therapy cancer treatment clinical trials Clinical use compassionate use comprehensive analysis COVID-19 COVID-19 outbreak COVID-19 pandemic dosage drug Drug repurposing effective energy metabolism ENhance feature health emergencies Human immune response information knowledge medication MOST nucleic acids pathway phase III trial preclinical study Protein SARS-COV-2 infection therapeutic approaches therapy time-consuming Toxicity Treatment Viral pneumonia viral replication virus-infected cell [DOI] 10.1186/s13046-020-01590-2 PMC 바로가기 [Article Type] Review