Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core proteinArticle Published on 2021-01-132023-06-03 Journal: Scientific Reports [Category] B형 간염, [키워드] Biochemistry Biological techniques Biophysical methods High-throughput screening Molecular biology Proteins Structure determination [DOI] 10.1038/s41598-020-79580-9 PMC 바로가기 [Article Type] Article
Dissecting the contribution of O-Antigen and proteins to the immunogenicity of Shigella sonnei generalized modules for membrane antigens (GMMA)Shigella sonnei의 막 항원에 대한 일반화 모듈(GMMA)의 면역원성에 대한 O-항원과 단백질의 기여 분석Article Published on 2021-01-132024-07-30 Journal: Burma Med J [Category] 세균성이질, [키워드] Biochemistry carbohydrates Diseases Immunological techniques Infectious diseases Isolation, separation and purification mass spectrometry Molecular engineering Proteomic analysis [DOI] 10.1038/s41598-020-80421-y PMC 바로가기 [Article Type] Article
Mechanism of SARS-CoV-2 polymerase stalling by remdesivirArticle Published on 2021-01-122022-10-04 Journal: Nature Communications [Category] 치료제, [키워드] active form addition Antiviral Biochemistry cause coronavirus Coronavirus replication COVID-19 patients COVID19 patients Cryo-electron microscopy cryo-EM structure Cryoelectron microscopy defined facilitate FDA-approved drug impair inhibit interfere mechanism molecular mechanism nucleotide observé polymerase Proofreading RdRP Remdesivir RNA RNA molecule RNA polymerase RNA synthesis RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp the SARS-CoV-2 translocation treat Treatment [DOI] 10.1038/s41467-020-20542-0 PMC 바로가기 [Article Type] Article
Enhanced surveillance of COVID-19 in Scotland: population-based seroprevalence surveillance for SARS-CoV-2 during the first wave of the epidemic스코틀랜드의 COVID-19 감시 강화: 전염병의 첫 번째 물결 동안 SARS-CoV-2에 대한 인구 기반 혈청 유병률 감시Article Published on 2021-01-012022-09-11 Journal: Public health [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% confidence interval adjusted age anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody antibodies antibody Asymptomatic Bayesian methods Biochemistry blood sample change Control coronavirus COVID-19 COVID-19 pandemic Critical denominator detect determine DiaSorin died enhanced estimation Europe First wave fraction General population geographical area Health authority help hospitalised IgG IgG antibodies Infection Italy Laboratory measure mild infection no difference organization Population proportion public health S1/S2 Sample SARS-CoV-2 Scottish Sensitivity and specificity serological surveillance serology Seroprevalence severity Sex study period Surveillance tested the epidemic Transmission turn [DOI] 10.1016/j.puhe.2020.11.014 PMC 바로가기 [Article Type] Article
High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme고친화성 나노바디는 SARS-CoV-2 스파이크 수용체 결합 도메인과 인간 안지오텐신 전환 효소의 상호작용을 차단합니다Article Published on 2020-12-222022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody fragment approved Biochemistry block COVID-19 pandemic derivative diagnostic Drug development effective enzyme expressing form HEK293 cell HEK293 cells high affinity human ACE2 Infection inhalation Interaction lead lentivirus Medical research nanobodies nanobody nebulization potency Proteins pseudotyped Receptor binding domain responsible SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein receptor binding domain Spike protein the SARS-CoV-2 the spike protein therapeutic Treatment variant virus [DOI] 10.1038/s41598-020-79036-0 PMC 바로가기 [Article Type] Article
The diagnostic accuracy of isothermal nucleic acid point-of-care tests for human coronaviruses: A systematic review and meta-analysis인간 코로나바이러스에 대한 등온 핵산 현장 진료 검사의 진단 정확도: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2020-12-182022-09-01 Journal: Scientific Reports [Category] MERS, 진단, [키워드] 95% CI Abbott Accuracy amplification applied article assessment Biochemistry bioRxiv Biotechnology calculate Cochrane Handbook coronavirus Coronaviruses COVID-19 COVID-19 patient CRISPR diagnose diagnostic Diagnostic accuracy Diagnostic specificities diagnostic specificity diagnostic test Diseases domains double-blinded evaluated focus Future guideline Handbook high risk identify isothermal isothermal amplification item Loop-mediated isothermal amplification medRxiv MERS Meta-analysis Microbiology Molecular biology Molecular medicine MOST nucleic acid Odds ratio offered on type Other patient cohorts patient selection peer-reviewed platform POCT point-of-care test purified RNA QUADAS-2 Quality reported Reporting Research reverse transcription review risk RNA extraction RNA purified RT-LAMP searched sensitivities sensitivity specificity systematic review systematic review and meta-analysis systematic reviews Test was used [DOI] 10.1038/s41598-020-79237-7 PMC 바로가기 [Article Type] Meta-Analysis
Biochemical and biophysical characterization of the main protease, 3-chymotrypsin-like protease (3CLpro) from the novel coronavirus SARS-CoV 2신종 코로나바이러스 SARS-CoV 2의 주요 프로테아제인 3-키모트립신 유사 프로테아제(3CLpro)의 생화학적 및 생물물리학적 특성 규명Article Published on 2020-12-172022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료제, [키워드] 3CLpro Activation Alter analytical techniques antiviral drug target antiviral therapeutics biochemical Biochemistry Biophysical chemistry buffer buffer solution calculated candidate condition conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Divalent drug enzymatic assay exhibited functional protein highest IMPROVE inhibitor inhibitors ionic strength kinetic lead less liberation maturation Novel coronavirus novel coronavirus disease parameter polyprotein processing protease reduced respiratory responsible salts SARS-CoV 2 SARS-CoV-2 setup Severe acute respiratory syndrome slope solubility stability thermodynamic Viral virus was recorded [DOI] 10.1038/s41598-020-79357-0 PMC 바로가기 [Article Type] Article
Safely reducing haemodialysis frequency during the COVID-19 pandemicResearch Article Published on 2020-12-072022-10-28 Journal: BMC Nephrology [Category] COVID-19, MERS, SARS, [키워드] approach Biochemistry change Compliance coronavirus COVID 19 COVID-19 COVID-19 pandemic COVID-19 transmission death dialysis fluid overload Frequency Haemodialysis help higher risk hospitalised increases in indication mitigate Mortality outcome Patient patients per protocol Potassium protocol receiving reduced reducing renal Result Safe SARS-CoV-2 SBP selected serum short term sodium statistically significant Systolic blood pressure transfer transferred Transmission treated twice weekly were recorded [DOI] 10.1186/s12882-020-02172-2 PMC 바로가기 [Article Type] Research Article
Syntheses of Salmonella Paratyphi A Associated Oligosaccharide Antigens and Development towards Anti-Paratyphoid Fever Vaccines살모넬라 파라티피 A 관련 올리고당 항원 합성과 항 파라티푸스 열 백신 개발Article Published on 2020-12-042024-08-21 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] 살모넬라증, [키워드] Bacteria Biochemistry glycosylation salmonella paratyphi a synthesis Vaccine
Association between biomarkers and COVID-19 severity and mortality: a nationwide Danish cohort study바이오마커와 COVID-19 심각도 및 사망률 사이의 연관성: 덴마크 전국 코호트 연구Article Published on 2020-12-022022-09-11 Journal: BMJ Open [Category] MERS, SARS, 바이오마커, [키워드] adjusted Admission adult intensive & age and gender Analysis association baseline level baseline levels Biochemistry Biomarker Biomarkers Bootstrapping C reactive protein cohort study Composite composite endpoint COVID-19 severity Critical Critical care CRP D-dimer death Denmark died Diseases EGFR elevated evaluate filtration rates general medicine (see internal medicine) glomerular filtration rate hospital ICU Infectious diseases Intensive intensive care intensive care unit internal medicine leucocyte leucocytes median age National normal outcome Patient patients with COVID-19 procalcitonin registry data retrospective cohort study risk significantly higher troponin urea ureas with COVID-19 [DOI] 10.1136/bmjopen-2020-041295 PMC 바로가기 [Article Type] Article