Pulmonary embolism severity index predicts adverse events in hospitalized COVID-19 patients: A retrospective observational study: PESI/sPESI and COVID-19 StudyResearch article Published on 2022-08-012022-10-05 Journal: Journal of cardiothoracic and vascular anesthesia [Category] 진단, 치료기술, [키워드] 95% confidence interval acute respiratory distress Admission adverse event adverse events age Analysis can be used cause clinically clinically suspected COVID-19 death evaluated hospital hospitalized COVID-19 hospitalized COVID-19 patient in-hospital mortality in-hospital mortality rate incidence independent risk factor intensive care invasive investigated measurement mechanical ventilation multivariate logistic regression noninvasive objective Odds ratio participant patients with COVID-19 polymerase chain positive predict Pulmonary embolism pulmonary embolism severity index (PESI) Respiratory distress syndrome Result retrospective scoring system sensitivity setting severity simplified PESI (sPESI) specificity study population syndrome the median Thromboembolic event venous Venous Thromboembolism women [DOI] 10.1053/j.jvca.2022.08.009 [Article Type] Research article
Twenty years of investigation with the case of prosopagnosia PS to understand human face identity recognition. Part I: FunctionResearch article Published on 2022-08-012022-10-05 Journal: Neuropsychologia [Category] 비임상, [키워드] Brain build cause cortical diagnostic disorder Face identity recognition facial function Holistic perception identity impairment include individual information Injury mandatory memory Part performed preserved Prosopagnosia Prosopdysgnosia PS recognize Single case specificity tested to define unique Visual recognition [DOI] 10.1016/j.neuropsychologia.2022.108278 [Article Type] Research article
Convolutional Neural Network Applied to SARS-CoV-2 Sequence ClassificationSARS-CoV-2 서열 분류에 적용된 컨볼루션 신경망Article Published on 2022-07-312022-09-11 Journal: Sensors (Basel, Switzerland) [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition approach Biotechnology cause caused center classification CNN Containment Contamination Convolutional neural network coronavirus COVID-19 deaths deep learning family genome sequence genomic sequence Health Organization instance limit mortality rate Mutation NCBI network Neural omicron Omicron variant organism outbreak pandemic parameters performed positive-sense RNA genome SARS-CoV-2 sequence sequences severe acute respiratory syndrome Coronavirus Spread subgenus subsequent the disease Transmission Treatment variant virus viruses World Health Organization [DOI] 10.3390/s22155730 PMC 바로가기 [Article Type] Article
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysisCOVID-19로 병원에 입원한 환자의 바리시티닙(RECOVERY): 무작위, 통제, 공개 라벨, 플랫폼 시험 및 업데이트된 메타 분석Meta-Analysis Published on 2022-07-302022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 28-day mortality 95% CI age-adjusted rate ratio allocation Baricitinib benefit by mouth cause Corticosteroid Corticosteroids COVID-19 COVID-19 therapy death deaths died discharge eight enrolled evaluate Evidence hospital hospitalised Including Infection inhibitor Innovation intention-to-treat population ISRCTN Jak JAK inhibitor jak inhibitors janus Janus kinase Medical Research Council Meta-analysis mouth nine Non-COVID-19 once daily Open-label outcomes Patient Platform trial Primary outcome Proportional reduction randomisation randomised randomised controlled trial Randomised Evaluation Randomly randomly assigned patient rate ratio receive receiving recorded recovery RECOVERY trial reduce mortality reduced reduction in mortality Registered risk of death significantly Standard of care suggested thrombosis Tocilizumab Treatment Trial trials usual care usual care alone usual care group was done with COVID-19 [DOI] 10.1016/S0140-6736(22)01109-6 PMC 바로가기 [Article Type] Meta-Analysis
Prognostic Value of Mid-Region Proadrenomedullin and In Vitro Interferon Gamma Production for In-Hospital Mortality in Patients with COVID-19 Pneumonia and Respiratory Failure: An Observational Prospective StudyCOVID-19 폐렴 및 호흡부전 환자의 병원 내 사망률에 대한 중간 지역 Proadrenomedullin 및 체외 인터페론 감마 생산의 예후적 가치: 관찰적 전향적 연구Observational Study Published on 2022-07-302022-09-11 Journal: Viruses [Category] MERS, 바이오마커, 임상, [키워드] 95%CI Admission Adult patients adverse outcome adverse outcomes AUROC best Biomarker cause characterized Coagulopathy Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 pneumonia COVID-19 vaccination cut-off cut-off point Deceased dysregulation endothelial damage enrolled Enrollment Evidence evidence of females Gamma groups Hospital mortality Hospitalization IFNγ immune dysregulation Immune suppression Immunocompromised patients in vitro in-hospital mortality infection risk interferon interferon gamma median age mid-region proadrenomedullin MONITOR Mortality MR-proADM Negative predictive value Non-COVID-19 observational study PaO2:FiO2 Patient patients with COVID-19 Pneumonia predict Predictive value predictive value) Production Prognostic factor Prospective quantiferon monitor. radiologic respiratory Respiratory failure SARS-CoV-2 sensitivity significantly specificity subset survivor the median value were measured with COVID-19 with infection [DOI] 10.3390/v14081683 PMC 바로가기 [Article Type] Observational Study
Human placenta-derived mesenchymal stem cells transplantation in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 (phase I clinical trial): safety profile assessmentClinical Trial Published on 2022-07-282022-10-05 Journal: Stem Cell Research & Therapy [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome (ARDS) administration adverse event Allogeneic Anti-inflammatory ARDS baseline cause caused Cell Cell therapy clinical Clinical sign clinical trial control group coronavirus COVID-19 COVID-19 pandemic death in COVID-19 demonstrated distress dose Efficacy enrolled evaluate evaluated feasible Health Hospitalization Human immunomodulatory injection intensive care intravenous Intravenous injection intravenously laboratory parameter Laboratory test mesenchymal stem cell morbidity and mortality not significantly different oxygen saturation participant Patient patients patients with ARDS patients with COVID-19 Phase I PL-MSC PL-MSCs Placenta mesenchymal stem cells (PL-MSC). protocol regenerative registry repeated Safe Safety assessment safety profile serum single dose standard treatment stem cell subject syndrome Treatment treatment group two group [DOI] 10.1186/s13287-022-02953-6 PMC 바로가기 [Article Type] Clinical Trial
Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation인간 계면활성제 단백질 D는 DC-SIGN 발현 세포에서 SARS-CoV-2 유사형 결합 및 진입을 촉진하고 스파이크 단백질 유도 염증을 하향 조절합니다Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 Analysis Anti-viral binding carbohydrate cause Cell cell interaction cell line cell surface receptor cells chemokine chemokines collectins controls COVID-19 cytokine cytokine response Cytokines DC-SIGN dendritic cell domain downregulate downregulated eight epithelial expressing facilitate fragment of HEK 293T HEK293T cell HEK293T cells help Human IFN-α IL- 6 IL-1β IL-8 immune function immune response immunomodulatory effect increase independent independent of infection assay infection assays Inflammation inhibit SARS-CoV-2 innate immune innate immune system Interaction intercellular involved Macrophage macrophages MHC class MHC class II modulating mRNA expression mRNA level mRNA levels N-terminal naïve T cell naïve T cells NF-κB pathogen Pathogens pro-inflammatory cytokine pro-inflammatory cytokines Protein pseudotype RANTES receptors Replication rfhSP-D. RNA virus RT-qPCR SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein shown SIGN spike Spike protein surface receptor T cells the Spike THP-1 TNF-α treated Treatment Vero Cell Vero cells viral entry viruses [DOI] 10.3389/fimmu.2022.960733 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Delta AY.1 Variant Cluster in an Accommodation Facility for COVID-19: Cluster ReportCOVID-19에 대한 숙박 시설의 SARS-CoV-2 Delta AY.1 변종 클러스터: 클러스터 보고서Article Published on 2022-07-282022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accommodation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered aerosol Aerosols AY.1 cause causes Cluster conditions conducted Contact coronavirus Delta Delta AY.1 effective examined facility FIVE help Infection infections interview measure molecular occur occurred positive positive result Prevent report routine SARS-CoV-2 SARS-CoV-2 test tested variant variant cluster. Ventilated Ventilation were infected [DOI] 10.3390/ijerph19159270 PMC 바로가기 [Article Type] Article
Commentary on Macrotroponin Complex as a Cause for Cardiac Troponin Increase after COVID-19 Vaccination and InfectionCOVID-19 예방 접종 및 감염 후 심장 트로포닌 증가의 원인으로서 마크로트로포닌 복합체에 대한 논평Comment Published on 2022-07-272022-09-12 Journal: Clinical Chemistry [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] cardiac cause COVID-19 increase troponin [DOI] 10.1093/clinchem/hvac101 PMC 바로가기 [Article Type] Comment
Global genomic analyses of wheat powdery mildew reveal association of pathogen spread with historical human migration and trade Research Published on 2022-07-262022-10-05 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, [키워드] America Analysis association cause China Crescent disease Eurasia European Evolution genomes genomic Human hybridized Japan Local Migration pathogen recent Spread strain Strains USA [DOI] 10.1038/s41467-022-31975-0 [Article Type] Research