class – Page 16 – Communicable Diseases Research

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

HLA 클래스 II 단백질의 아미노산 변이는 일반적인 바이러스에 대한 체액 반응의 주요 결정 요인입니다

Report

Published on 2015-11-052022-08-07
Journal: American Journal of Human Genetics [Category] 유전자 메커니즘,

The Tomato Yellow Leaf Curl Virus Resistance Genes Ty-1 and Ty-3 Are Allelic and Code for DFDGD-Class RNA–Dependent RNA Polymerases

토마토 황엽말림 바이러스 내성 유전자 Ty-1 및 Ty-3은 대립유전자이고 DFDGD-Class RNA-Dependent RNA 중합효소에 대한 코드입니다

Research Article

Published on 2013-03-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] allele alleles allelic amplification approach atypical DFDGD motif Author begomovirus begomovirus species Breeding catalytic DLDGD motif catalytic domain cause caused characterized chromosomal region chromosome chromosome 6 class code Combination described different disease geminivirus geminiviruses Gene gene functions genomic region inbred lines induced introgression leaf mapped marker mechanism molecular molecular markers Multiple plant plants RDR RDRα RDRα type RDRγ recent finding recent findings recombinant inbred lines recombination event Region related resistance resistance gene resistance genes resistance mechanism RNA RNA–dependent RNA polymerase shown Solanum chilense Solanum chilense –derived Ty-1 and Ty-3 genes specificity subtropical susceptible these viruses Tobacco Tobacco Rattle Virus tomato Tomato yellow leaf curl virus Tomato Yellow Leaf Curl Virus Disease transcriptional tropical Ty-1 Ty-1 and Ty-3 Ty-1/Ty-3 gene Ty-3 TYLCV virus Virus Disease viruses yellow
[DOI] 10.1371/journal.pgen.1003399 PMC 바로가기 [Article Type] Research Article

ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

ImmunoChip 연구는 기면증에서 T 세포에 대한 항원 제시를 의미합니다

Research Article

Published on 2013-02-142022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] addition Alpha Antigen presentation antigen processing Author Autoimmune autoimmune and inflammatory diseases autoimmune attack Autoimmune disease Cathepsin H chromosome chromosome 6 class compared Consensus Control controls CTSH deficiency disease pathogenesis disease risk encoded protein encoded proteins environmental exposure European Gene Genes genome-wide significance genotyped genotyping high-density genotyping platform HLA HLA class II HLA DQB1*06:02 Human human leukocyte antigen hypocretin cells ImmunoChip immunological synapse implicated in addition to individual inflammatory disease Inflammatory diseases Interaction leukocyte Ligand loci mechanism Narcolepsy narcolepsy-hypocretin deficiency OX40L pathophysiology pathway post-infectious autoimmune presentation progression recent selective significantly study variant Support susceptibility T cell T cell receptor T cell response T cells the disease TNFSF4 TNFSF4/OX40L tumor necrosis tumor necrosis factor unique variant variants while
[DOI] 10.1371/journal.pgen.1003270 PMC 바로가기 [Article Type] Research Article

miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다

Research Article

Published on 2013-02-142022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction
[DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article

The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove

HLA 클래스 I 항원 인식 그루브와 관련된 중국 비인두암의 주요 유전적 결정인자

Research Article

Published on 2012-11-292022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] allele allele frequencies alleles Amino acid Analysis analyzed antigens association associations Author binding Cancer carcinoma carried China Chinese chromosome chromosome 6 class Cohort concert dependent on detect detected determinant disease driven by EBV epithelial Epstein-Barr virus examined facilitated GABBR1 Gene gene region genetic influence Genome-wide association study Groove Guangdong Guangxi GWAS HCG9 help High-resolution HLA HLA alleles HLA class I HLA class I gene HLA region HLA-A HLA-A and -B HLA-B HLA-F incidence independent Infection influences influences on Interaction involved large cohort Linkage disequilibrium malignancy molecular motif multivariate Nasopharyngeal carcinoma NPC nucleotide operative OR2H1 over peptide performed physically principal Recognition recognize Region regression analysis replicate Replication resolved risk second sequence SNP SNPs statistical study participant the major histocompatibility the strongest variant variants virus infection
[DOI] 10.1371/journal.pgen.1003103 PMC 바로가기 [Article Type] Research Article

SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus

SREBP는 인간 곰팡이 병원체 Aspergillus fumigatus에서 트리아졸 약물 및 저산소증 반응을 중재하기 위해 철과 에르고스테롤 항상성을 조정합니다

Research Article

Published on 2011-12-012022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] A. fumigatus acquisition activated adaptation Adding addition advance Aspergillus fumigatus Author binding Candida albican Candida albicans caused cellular response class clinically condition conditions Coordinate Critical Cryptococcus neoforman Cryptococcus neoformans decrease dependent on drug drug susceptibility drugs ergosterol eukaryotes found foundation fungal fungal infections fungal pathogen Gene Genetic growth growth defect Health Human hypoxia hypoxic identify immunocompromised condition infections initial involved iron iron homeostasis Iron metabolism led to lethal disease majority mechanism metabolism microenvironment Most patients mRNA mutant mutants pathogenic Pathogens Patient phenotype Protein regulate Regulation regulatory element required response restoration Sterol Support susceptibility susceptible These data transcription factor transcription factors triazole virulence
[DOI] 10.1371/journal.pgen.1002374 PMC 바로가기 [Article Type] Research Article

Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis

인터페론 조절 인자 8은 골수 세포 및 결핵 기간 동안 항원 제시 경로를 조절합니다

Research Article

Published on 2011-06-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] (major histocompatibility complex activate Activation allele Analysis Antigen presentation antigen processing Author binding binding site cellular pathway cellular pathways chromatin chromatin immunoprecipitation class Combination component Critical cytokine Defense dendritic cell dendritic cells differentiation early response endomembrane eQTLs expressed expression F2 Factor fixed functional Gene gene transcription GTPase GTPases histocompatibility complex Host–pathogen interaction identify IFNγ IL-12 IL12 immune response Infected Infection interferon gamma interferon regulatory factor interleukin intracellular pathogens intrinsic investigated IRF8 lipopolysaccharide LPS lung tissue lung tissues Lungs Macrophage macrophages major histocompatibility complex maturation member MHC mice Microarray Microarrays microbial motif mutant Mycobacterium tuberculosis myeloid myeloid cell myeloid cells ontogeny Pathogens pathway Pathways presentation priming progenitor cells promoter promoters Proteins pulmonary tuberculosis regulated Regulation represse required resistance to infection resistance to infections significantly Stimulation susceptible target transcript Transcription transcriptional treated Tuberculosis wild-type
[DOI] 10.1371/journal.pgen.1002097 PMC 바로가기 [Article Type] Research Article