CoVs – Page 16 – Communicable Diseases Research

[Immunity against SARS-CoV-2: walking to the vaccination]

[SARS-CoV-2에 대한 면역: 예방 접종을 위해 도보]

Review

Published on 2020-12-012022-09-11
Journal: Revista española de quimioterapia : publicación [Category] MERS, SARS, 임상, 진단, 치료법,

RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

RBD-Fc 기반 COVID-19 백신 후보, 매우 강력한 SARS-CoV-2 중화 항체 반응 유도

Article

Published on 2020-11-272022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 진단, 치료기술,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antigen Antisera binding caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines CoVs domain dominant Economy effective Effective vaccines elicited Epitopes Fc fragment fragment of global health Health human ACE2 IgG immunization Immunopotentiator induce Infection infections live SARS-CoV-2 mice mutants natural mutation natural mutations neutralization neutralize Neutralizing activity neutralizing epitope pandemic Prevent PROTECT pseudotyped pseudotyped SARS-CoV-2 RBD RBD-Fc RBD-specific antibodies RBD-specific antibody receptor Receptor-binding domain respiratory responsible robust Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 neutralizing antibody SARS-CoV-2 RBD SARS-related coronavirus SARSr-CoV SARSr-CoVs severe acute respiratory syndrome Coronavirus specific antibodies Spike protein subunit Subunit vaccine the SARS-CoV-2 the spike protein threat transgenic mice Vaccine Vaccines
[DOI] 10.1038/s41392-020-00402-5 PMC 바로가기 [Article Type] Article

Could Naturally Occurring Coronaviral Diseases in Animals Serve as Models for COVID-19? A Review Focusing on the Bovine Model

Review

Published on 2020-11-262022-10-28
Journal: Pathogens [Category] COVID-19,

Computational Investigation of Structural Dynamics of SARS-CoV-2 Methyltransferase-Stimulatory Factor Heterodimer nsp16/nsp10 Bound to the Cofactor SAM

Molecular Biosciences

Published on 2020-11-242022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] absence antiviral drug approved Area association binding binding mechanism Bound CAS caused characterized conformational contagious contribute coronavirus COVID-19 CoVs Dynamics electrostatic interaction ENCODE enzyme eukaryotic Factor highlight hotspot Hydrogen bond hydrophobic interaction identify identifying increase interactions investigated investigation Mechanics mechanism methyltransferase MM-PBSA MM/PBSA molecular dynamics Molecular dynamics simulation mRNA Mutagenesis mutants novel coronavirus disease Nsp16/nsp10 PCA Peptide inhibitor protein translation provide public health RNA stability S-adenosyl-L-methionine SAM SARS-CoV-2 scanning surface therapeutic agents thermodynamic Vaccine van der Waal virus was performed
[DOI] 10.3389/fmolb.2020.590165 PMC 바로가기 [Article Type] Molecular Biosciences

Drawing Comparisons between SARS-CoV-2 and the Animal Coronaviruses

Review

Published on 2020-11-232022-10-29
Journal: Microorganisms [Category] COVID-19,

Fatal Interstitial Pneumonia Associated with Bovine Coronavirus in Cows from Southern Italy

Article

Published on 2020-11-192022-10-28
Journal: Viruses [Category] Coronavirus,

The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin SARS‐COV‐2 chimeric structure and furin cleavage site might be the result of genetic manipulation

Problems & Paradigms

Published on 2020-11-172022-10-27
Journal: Bioessays [Category] COVID-19,

The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin SARS‐COV‐2 chimeric structure and furin cleavage site might be the result of genetic manipulation

Problems & Paradigms

Published on 2020-11-172022-10-27
Journal: Bioessays [Category] Coronavirus, COVID-19, SARS,

Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?

Pharmacology

Published on 2020-11-092022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] activate acute respiratory syndrome adaptive Anti-viral Antiviral Antiviral compound antiviral drug approach approaches approved drug benefit cause chaperone clinical development clinical trials coronavirus Course COVID-19 COVID-19 pandemic COVID-19 patients CoVs Drug repurposing drugs Endoplasmic reticulum ER membranes ER stress expected facilitate Health host cell host cell response host protein identify in vitro Infection infections interact Interaction interfere Intervention Ligand mechanism Medicine membrane-bound modulation occur pathway patients potential mechanism Prevent professional protective immune response Proteins provide receptor reduce regulate Repurposed drugs repurposing SARS-CoV-2 SARS-CoV-2 protein sigma-1 receptor Stress targeting the disease therapeutic therapy treat unique upstream viral replication
[DOI] 10.3389/fphar.2020.582310 PMC 바로가기 [Article Type] Pharmacology

The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

코로나바이러스 세포 진입 및 복제에서 시스테인 펩티다제의 역할: 카텝신 억제제의 치료 가능성

Review

Published on 2020-11-022022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, COVID-19,

[키워드] Activation antiviral drug cathepsin inhibitor Cathepsins cell entry cells chymotrypsin Coronaviral coronavirus CoV CoVs cysteine Diseases generate Host host cell humans inhibitor involved lysosomal nonstructural protein nonstructural proteins Nsps outcomes over Papain peptidase positive-sense prevalent processed replicase polyprotein replicase polyproteins Replication respiratory respiratory diseases RNA viruses severe respiratory diseases single-stranded spike glycoprotein spike glycoproteins Spike protein targets therapeutic potential treatment strategy utilization Viral Viral RNA viral RNA synthesis virus attenuation
[DOI] 10.1371/journal.ppat.1009013 PMC 바로가기 [Article Type] Review