Central and peripheral nervous system complications of COVID-19: a prospective tertiary center cohort with 3-month follow-upCOVID-19의 중추 및 말초 신경계 합병증: 3개월 추적 관찰이 있는 예비 3차 센터 코호트Observational Study Published on 2021-01-132022-09-10 Journal: Journal of Neurology [Category] MERS, SARS, 임상, 치료기술, [키워드] Admission Adult patients akinetic mutism biopsy caused causes cerebrospinal fluid change CNS Cohort collected Complication conducted coronavirus COVID-19 COVID-19 patients Critical Critical illness discharge during admission Electronic health records Encephalitis Encephalopathy enrolled Follow-up hospitalized COVID-19 patients ICU ICU admission Immune-mediated independent Intensive intensive care investigated Ischemic Stroke Laboratory Length management mechanisms meralgia meralgia paresthetica Myelitis nervous system neurological Neurological disease Neuropsychiatric non-ICU non-ICU patients objective observational study Other Patient remained required Respiratory failure Result SARS-CoV-2 SARS-CoV-2 neurotropism SARS-CoV-2 RNA screened secondary to stroke suggested supplementary material Symptom transverse myelitis Viral [DOI] 10.1007/s00415-020-10380-x PMC 바로가기 [Article Type] Observational Study
Effect of early oxygen therapy and antiviral treatment on disease progression in patients with COVID-19: A retrospective study of medical charts in ChinaCOVID-19 환자의 질병 진행에 대한 조기 산소 요법 및 항바이러스 치료의 효과: 중국의 의료 차트에 대한 후향적 연구Research Article Published on 2021-01-062022-09-10 Journal: PLoS Neglected Tropical Diseases [Category] MERS, 치료제, [키워드] 95%CI antiviral drug antiviral drugs Antiviral treatment carried China clinical feature Clinical features coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 mortality Critical Critical illness critical patients Critically ill Critically ill patient critically ill patients described Disease progression Effect effective Effectiveness Evidence expand exploratory groups hospital hospitalized patient hospitalized patients Hypoxemia hypoxia identify IFNα Infection Initiation less lower mortality lower risk medical intervention Medical resources Mild multivariable analyses oxygen Oxygen therapy Oxygen treatment pandemic Patient patients Prevalence recommendation retrospective retrospective review Retrospective study risk factor Risk factors risk of death seeking severe disease severity significantly significantly higher Support Symptom symptom onset symptomatic Symptoms symptoms onset the patient the timing these symptom these symptoms Tongji Hospital treated with COVID-19 Wuhan [DOI] 10.1371/journal.pntd.0009051 PMC 바로가기 [Article Type] Research Article
Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort studyArticle Published on 2021-01-032023-06-14 Journal: Intensive care medicine [Category] Fulltext, MERS, [키워드] COVID-19 Critical illness SARS-CoV-2 Ventilator-associated pneumonia Ventilator-associated tracheobronchitis [DOI] 10.1007/s00134-020-06323-9 PMC 바로가기
Hemoperfusion with CytoSorb as Adjuvant Therapy in Critically Ill Patients with SARS-CoV2 PneumoniaSARS-CoV2 폐렴이 있는 중환자에서 보조 요법으로 CytoSorb를 사용한 혈액관류Observational Study Published on 2021-01-012022-09-11 Journal: Blood purification [Category] SARS, 임상, 진단, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome adjuvant adjuvant therapy Anticoagulant Antiviral approved ARDS Blood Blood purification C-reactive protein cartridge Case report Clinical course Clinical outcome conducted consecutive patient Continuous Positive Airway Pressure control patient control patients coronavirus coronavirus 2 coronavirus disease Course COVID COVID-19 COVID-19 patients Critical illness Critical illness cytokines Cytokines Cytosorb develop diagnosed died Effectiveness effector Evidence greater Hemoperfusion Hospital admission Hospitalized IL-10 IL-6 IL-8 Ill IMPROVE include Inflammation inflammatory state intensive care unit Intubated intubation limited sample size lymphocytopenia Measures mechanism medical emergency observational study oxygen oxygen supplementation pathogenic Patient patients Pneumonia positive airway pressure randomized clinical trial remained required respiratory respiratory distress Respiratory function respiratory specimens reverse transcription-PCR SARS-CoV2 scenario sequence severe acute respiratory distress syndrome Severe acute respiratory syndrome severe pneumonia Study design survived syndrome therapeutic therapeutic strategy therapy tissue injury TNF-α treated treated patient treated patients Treatment virus worsened [DOI] 10.1159/000511725 PMC 바로가기 [Article Type] Observational Study
Understanding the andromeda strain – The role of cytokine release, coagulopathy and antithrombin III in SARS-CoV2 critical illness안드로메다 균주 이해 - SARS-CoV2 중병에서 사이토카인 방출, 응고병증 및 안티트롬빈 III의 역할Review Published on 2021-01-012022-09-11 Journal: Blood reviews [Category] SARS, 바이오마커, [키워드] Antithrombin antithrombin III autopsy analysis benefit China circulating Coagulation Coagulopathy coronavirus COVID-19 COVID-19 infections Critical Critical illness cytokine release Europe globe hematology heparin Heparin resistance mediator Microthrombosis Mortality Multiple observational studies observational study organizations pandemic Part pathology pathophysiology Patient performed physician potential therapeutic target Prognostic marker Prophylactic prothrombotic reduction reductions reported SARS-CoV SARS-CoV critical illness SARS-CoV2 severe COVID-19 infections Society temper thrombosis thrombotic thrombotic complication Thrombotic complications understanding [DOI] 10.1016/j.blre.2020.100731 PMC 바로가기 [Article Type] Review
Be aware of acute kidney injury in critically ill children with COVID-19COVID-19에 감염된 위독한 어린이의 급성 신장 손상에 대해 알고 있어야 합니다.Case Reports Published on 2021-01-012022-09-11 Journal: Pediatric Nephrology (Berlin, Germany) [Category] 임상, 치료기술, [키워드] Activation Acute kidney injury Admission AKI children with COVID-19 Children's Hospital CKRT clinical clinical courses Clinical presentations complement Complement activation complete recovery conducted coronavirus courses COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic Critical Critical illness Critically ill critically ill adult patients Critically ill patient critically ill patients described develop early stage early stages electronic medical records elevated gastrointestinal symptoms ICU IL-6 impairment implantation incidence inflammatory storm Injury intensive care intensive care unit interleukin-6 investigated kidney Kidney injury Laboratory management mechanism medical intervention medical records Mortality non-critically ill patient observational study outbreak patients with AKI patients with COVID-19 pediatric Pediatric patient Pediatric patients plasma plasma exchange Plasmapheresis replacement therapy resulting retrospective SARS-COV-2 infection Support therapy treated Treatment underlie with COVID-19 Wuhan [DOI] 10.1007/s00467-020-04715-z PMC 바로가기 [Article Type] Case Reports
Spectrum of neuroimaging findings in COVID-19COVID-19의 신경 영상 소견 스펙트럼Pictorial Review Published on 2021-01-012022-09-12 Journal: The British Journal of Radiology [Category] 진단, [키워드] Acute disseminated encephalomyelitis change China Complication COVID-19 Critical Critical illness Critically ill Disseminated encephalomyelitis Encephalopathy feature flare Hemorrhagic hospitalized COVID-19 hospitalized patient hospitalized patients hypertensive hypoxic include infections manifestation meningoencephalitis multiple sclerosis Neurological complications outbreak positive patient Spectrum spread to state stroke syndrome thrombosis Venous thrombosis Viral Virus Disease worldwide pandemic [DOI] 10.1259/bjr.20200812 PMC 바로가기 [Article Type] Pictorial Review
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19세로 다중 오믹스 분석을 통해 거핵구, 적혈구계 세포 및 형질모세포의 반응을 중증 COVID-19의 특징으로 식별Article Published on 2020-12-152022-09-11 Journal: Immunity [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] acute respiratory distress adaptive analyzed BCR Biomarker Biomarkers Blood cells cellular characterized circulating co-expression Cohort COVID-19 COVID-19 disease COVID-19 patients Critical Critical illness disease disease trajectory DNA Effect erythroid erythropoiesis expansion fatal disease feature hallmark hypoxic immune Immune cell immune cells immune response immune responses independent Infectious disease interferon longitudinal megakaryocyte Methylation outcome patients patients with COVID-19 performed Peripheral blood peripheral blood samples plasmablast plasmablasts Predictive predictor profiles provide respiratory respiratory distress response RNA-Seq SARS-COV-2 infection scRNA-seq severe COVID-19 severe COVID-19 disease Signaling single-cell skewed Temporal Temporal resolution trajectory Transcriptome Treatment validation virus was performed [DOI] 10.1016/j.immuni.2020.11.017 PMC 바로가기 [Article Type] Article
Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19혈장의 바이러스 RNA 부하는 COVID-19의 심각한 질병 및 조절되지 않는 숙주 반응과 관련이 있습니다Research Published on 2020-12-142022-09-11 Journal: Critical Care [Category] MERS, 바이오마커, 진단, 치료제, [키워드] Activation Analysis angiopoietin association Biomarker Biomarkers Blood CCL2 characterized chemokine chemokines Coagulation correlated correlation coefficients correlations Course COVID-19 Critical Critical illness critical patient critical patients Critically ill Critically ill patient critically ill patients CRP CXCL10 cytokine D-dimer digital PCR disease dysregulated dysregulated response dysregulation Endothelial dysfunction evaluated ferritin Frequency GM-CSF GPT highest Hospitalized host response host responses ICAM-1 ICU ICU Patients IL-10 IL-15 IL-6 INR LDH lymphopenia monocytopenia Multivariate analysis multivariate logistic regression myeloperoxidase N1 and N2 neutrophil neutrophil response Neutrophils NK cell NK cells non-critically ill patients non-survivor Non-survivors Outpatient outpatients Pathogenesis Patient patients with COVID-19 PD-L1 plasma quantification recruited Region respiratory respiratory sample Respiratory samples Result RNA RNAemia SARS-CoV-2 SARS-CoV-2 RNA Sepsis severe COVID-19 severity Spearman Stool systemic inflammatory response the SARS-CoV-2 tissue damage Urine VCAM-1 Viral viral replication Viral RNA viral RNA detection viral RNA load virus ward was performed [DOI] 10.1186/s13054-020-03398-0 PMC 바로가기 [Article Type] Research
A low dose heparinized saline protocol is associated with improved duration of arterial line patency in critically ill COVID-19 patients저용량 헤파린화 식염수 프로토콜은 중환자의 동맥관 개통 기간 개선과 관련이 있습니다.Observational Study Published on 2020-12-012022-08-31 Journal: Journal of critical care [Category] MERS, 임상, 치료제, [키워드] age arterial line assessment baseline characteristics bleeding bleeding risk Characteristics clinically Cohort cohorts Complication coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient COVID-19 patients Critical illness Critically ill Critically ill patient critically ill patients Efficacy episode episode of failure groups heparin ICU incidence low dose material median Observational cohort study Patient protocol risk significantly systemic anticoagulation thrombosis Vascular access Vascular access devices Vascular access devices. with COVID-19 [DOI] 10.1016/j.jcrc.2020.08.025 PMC 바로가기 [Article Type] Observational Study