Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort studyOriginal Article Published on 2022-02-182022-10-30 Journal: Nephrology, dialysis, transplantation : official p [Category] COVID-19, SARS, [키워드] 28-day mortality 95% confidence interval acute kidney Acute kidney injury Admission adults hospitalized AKI biochemical Biochemistry Black race Chronic kidney disease CKD cohort study Comorbidity coronavirus disease COVID-19 Dexamethasone dialysis explained high-risk patient include investigated ISARIC WHO CCP-UK Kidney function Kidney injury Male sex Mortality multicentre Odds ratio pandemic Patient patients patients hospitalized peaked Remdesivir renal failure Result risk risk factor SARS-CoV-2 severity subsequent therapy UK hospital was performed with COVID-19 [DOI] 10.1093/ndt/gfab303 PMC 바로가기 [Article Type] Original Article
Remdesivir in combination with dexamethasone for patients hospitalized with COVID-19: A retrospective multicenter studyCOVID-19로 입원 한 환자를위한 덱사메타손과 함께 Remdesivir : 후 향적 다기관 연구Multicenter Study Published on 2022-02-172022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] 1:1 addition Admission Algorithm analyzed balance checked clinical benefit Combination COVID-19 pneumonia death death rate death rates Dexamethasone duration of hospitalization Hospital mortality Hospitalization hospitalized patient hospitalized patients In-hospital death in-hospital mortality Infectious disease Infectious diseases intensive care intensive care unit Logistic low-flow oxygen male Male sex matching mean differences median median time multivariable outcome oxygen Patient patients hospitalized patients with COVID-19 Pneumonia populations Primary outcome prognostic Propensity score receiving reduced Remdesivir replacement Result retrospective cohort study Retrospective multicenter study secondary Secondary outcomes Standard deviation Standard of care symptoms onset transfer Treatment was performed with COVID-19 [DOI] 10.1371/journal.pone.0262564 PMC 바로가기 [Article Type] Multicenter Study
Decreased serum levels of angiotensin converting enzyme (ACE)2 and enhanced cytokine levels with severity of COVID-19: normalisation upon disease recoveryResearch Article Published on 2022-02-162022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] acute respiratory syndrome Admission affected Angiotensin-converting enzyme baseline Blood cause circulating cytokine clinical outcomes Combination component coronavirus coronavirus disease COVID-19 cytokine level Cytokines Decreased Dexamethasone disease disease severity ELISA enrolled enzyme Future HCs healthy control IL-6 IL-8 increase in Infection main receptor Mild moderate Moderate COVID-19 moderate disease Normalisation objective Patient patient group patients treated patients with moderate PCR-confirmed peripheral pilot study promote Remdesivir renin-angiotensin system Result sACE2 SARS-CoV-2 Serum level severe COVID-19 patient severe disease severity significantly significantly increased subject systemic systemic cytokine treated Treatment was obtained were measured [DOI] 10.1016/j.heliyon.2022.e08957 PMC 바로가기 [Article Type] Research Article
COVID-19 Treatments Sold Online Without Prescription Requirements in the United States: Cross-sectional Study Evaluating Availability, Safety and Marketing of Medications미국에서 처방전 없이 온라인으로 판매되는 COVID-19 치료제: 의약품의 가용성, 안전성 및 마케팅을 평가하는 횡단면 연구Original Paper Published on 2022-02-162022-09-10 Journal: Journal of Medical Internet Research [Category] COVID19(2023년), SARS, 치료제, [키워드] adverse effects Care Characteristics claimed clinical evidence clinical response conducted counseling COVID-19 COVID-19 pandemic COVID-19 treatment COVID-19 treatments cross-sectional cross-sectional study demonstrated Dexamethasone drug Drug interactions effective Efficacy English evaluated Evaluating Evidence Google Health Health care highlight Hydroxychloroquine hydroxychloroquine) Identified Internet lack Lopinavir Lopinavir-ritonavir measure medication medications Medicines mimicking MONITOR objective offer offered online pharmacy pandemic patients Pharmacy potential COVID-19 treatments prescription Prescriptions professional required Requirement Result Ritonavir Safety Safety measures scientific evidence seeking self-treatment Support the United State treat Treatment unique United States website were recorded Yahoo! [DOI] 10.2196/27704 PMC 바로가기 [Article Type] Original Paper
Role of Dexamethasone and Methylprednisolone Corticosteroids in Coronavirus Disease 2019 Hospitalized Patients: A ReviewMicrobiology Published on 2022-02-152022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Anti-inflammatory Autoimmune diseases bloodstream Characteristics China Clinical outcome combating coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient COVID-19 patients database Dexamethasone Direct disease dosage drug drugs genomic effects immune response immune system Immunocompromised immunomodulatory Impact Inflammation Inflammatory inflammatory impacts inhibit Interaction leukemia literature management medication Methylprednisolone modulate Multiple myeloma non-genomic non-Hodgkin’s lymphoma Open-label pandemic disease Patient Perspective Pharmacodynamics pharmacokinetics physical Pneumonia Population produced Randomized recommendation RECOVERY trial reduce Research review role Safe Science searched seeking shown supplemental oxygen survival Symptom tissue toxicology Trial use of corticosteroid Vaccine WHO with COVID-19 [DOI] 10.3389/fmicb.2022.813358 PMC 바로가기 [Article Type] Microbiology
Comparison between methylprednisolone infusion and dexamethasone in COVID-19 ARDS mechanically ventilated patientsResearch Published on 2022-02-152022-10-31 Journal: The Egyptian Journal of Internal Medicine [Category] COVID-19, [키워드] acute respiratory distress Analysis ARDS Berlin both group caused Chest Clinical outcome coronavirus Coronavirus disease 2019 Corticosteroid Course COVID-19 COVID-19 pneumonia CRP Cytokine storm D-dimer decrease Dexamethasone diagnosed discharge dose effective effective therapy evaluated ferritin fraction Ground glass opacity ICU inclusion criteria Inflammatory marker intensive care intensive care patient invasive mechanical laboratory result LDH less lymphocyte marker material mechanical ventilation mechanically ventilated mechanically ventilated patient Methylprednisolone methylprednisolone group Mortality neutrophil optimal dose overall mortality oxygen oxygen supplementation P/F ratio Patient patients treated Pneumonia polymerase chain Previous studies prospective cohort study Protein radiological radiological finding required Result SARS-CoV-2 SARS-CoV-2 pneumonia Severe COVID-19 pneumonia severity statistically significant Steroids survival syndrome the patient tomography treated Treatment university were given [DOI] 10.1186/s43162-022-00113-z PMC 바로가기 [Article Type] Research
Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein합성 비리온은 SARS-CoV-2 스파이크 당단백질의 지방산 결합 적응 면역원성을 나타냅니다.Article Published on 2022-02-142022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] adaptation adaptive binding binding pocket Bioinspired materials Cell conserved convalescent COVID-19 COVID-19 progression Dexamethasone Donor fatty Fatty acid fatty acids FDA-approved drug FFAs free fatty acid function global public health glycoprotein heterogenous Host immune response immunogenicity Immunoglobulin immunoglobulins Inflammation Inflammatory integrin Live virus mechanism mimicking modulate molecular motif Mutant SARS-CoV-2 neutralization activity Neutralizing open Pathogenesis preparation pro-inflammatory proinflammatory protocol RBD Receptor binding Receptor binding domain Regulation Regulatory responsible reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein synthetic the SARS-CoV-2 Variability Viral virion vitamin K wild-type [DOI] 10.1038/s41467-022-28446-x PMC 바로가기 [Article Type] Article
Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patientsRandomized Controlled Trial Published on 2022-02-142022-10-04 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 Abstract Administered administration affected approved caused Central nervous system Clinical improvement clinical trial CNS concentrations conducted COVID-19 COVID-19 patient Critical death defined Dexamethasone dose doses dysregulated Effectiveness Efficacy FIVE Glucocorticoids group health institution Hospitalization IMPROVE individual Inflammation intranasal intranasal administration intranasally intravenous intravenously low dose Mexico City moderate multi-organ dysfunction multicenter Neuroinflammation Open-label Patient patients Primary outcome protocol Randomized Randomized controlled trial recruited reduce reduce mortality reduction in mortality regimen respiratory tract secondary outcome severe COVID-19 severe COVID-19 patients statistically significant reduction systemic inflammation therapeutic therapeutic dose treated triggering two group [DOI] 10.1186/s13063-022-06075-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Study find that COVID ARDS was associated with a low risk for possible or proven PCP: still true after dexamethasone useLetter Published on 2022-02-102022-11-01 Journal: Critical Care [Category] Coronavirus, COVID19(2023년), SARS, [키워드] ARDS COVID COVID ARDS Dexamethasone High occurrence PCP risk [DOI] 10.1186/s13054-022-03886-5 PMC 바로가기 [Article Type] Letter
Mechanism of Caspase-1 Inhibition by Four Anti-inflammatory Drugs Used in COVID-19 TreatmentCOVID-19 치료에 사용되는 4가지 항염증제에 의한 Caspase-1 억제 메커니즘Article Published on 2022-02-062022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, 치료제, [키워드] “cytokine storm” active site activity alleviate Amino acid analyzed anti-inflammatory drug Anti-inflammatory drugs antioxidant carbonyl caspase caspase-1 cause causes Colchicine Compound Computational methods Corticosteroid covalent bond COVID-19 COVID-19 infection COVID-19 therapy COVID-19 treatment cytokine cytokine release Cytokine storm Cytokines death Dexamethasone drug drugs effective excessive cytokine production help indicated Inflammatory Inflammatory response inhibition inhibitor mechanism Methylprednisolone molecular protease protons raloxifene reported residue scavenging Superoxide therapy these compounds transfer Treatment Trigger triggers [DOI] 10.3390/ijms23031849 PMC 바로가기 [Article Type] Article