The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general populationResearch Paper Published on 2021-02-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, [키워드] age age and sex Cancer cardiovascular disease contributing to Course COVID-19 COVID-19 mortality death declining European exceeded females FIVE France General population Germany Government higher risk Italy male-to-female ratio mechanism Mortality Netherlands Sex Spain stratified with COVID-19 [DOI] 10.18632/aging.202639 PMC 바로가기 [Article Type] Research Paper
SARS-CoV-2 Seroprevalence in Healthcare Workers of Kaunas Hospitals during the First Wave of the COVID-19 PandemicCOVID-19 팬데믹의 첫 번째 물결 동안 Kaunas 병원 의료 종사자의 SARS-CoV-2 혈청 유병률Article Published on 2021-02-062022-09-10 Journal: Medicina [Category] MERS, 진단, 치료기술, [키워드] Acute respiratory infection acute respiratory symptoms anti-SARS-CoV-2 Antibody testing Appetite Blood capillary capillary blood conjunctivitis Contact contact with cough COVID-19 demographics determine diagnosis of COVID-19 diarrhea direct contact Dyspnea ELISA enrolled enzyme-linked immunosorbent enzyme-linked immunosorbent assay exceeded general practitioner headache healthcare worker Healthcare workers hospital Hospitalized IgA class IgG IgM immunoassay Immunoglobulin Immunoglobulin G immunoglobulin M immunoglobulins individual Lateral lateral flow immunoassay loss of appetite Loss of Smell loss of smell and taste material muscle pain nausea Pain positive predominant question questionnaire representing respiratory Result SARS-CoV-2 SARS-CoV-2 antibody testing SARS-CoV-2 seroprevalence serologic serologic testing Seroprevalence serum sample serum samples study participant Study participants Symptom Taste tested was used Wave were used with COVID-19 worker [DOI] 10.3390/medicina57020148 PMC 바로가기 [Article Type] Article
High-level expression of the monomeric SARS-CoV-2 S protein RBD 320-537 in stably transfected CHO cells by the EEF1A1 -based plasmid vectorEEF1A1 기반 플라스미드 벡터에 의한 안정적으로 형질감염된 CHO 세포에서 단량체 SARS-CoV-2 S 단백질 RBD 320-537의 고수준 발현Research Article Published on 2021-02-022022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, [키워드] Accuracy acute respiratory syndrome Alpha amplification analyzed Antigen antigenic antigenic determinants C-terminal Cell culture cell line Chinese hamster CHO cell condition coronavirus coronavirus 2 Coronaviruses described determinant domain EEF1A1 elongation factor exceeded except for expression gel gel filtration Genetic Genome glycans glycosylation Host immune response inducer mammalian mass spectrometry methotrexate monomeric N-glycosylation peptide performed Plasmid PNGase F polyacrylamide polyacrylamide gel produced Protein purification RBD RBD protein recombinant Recombinant SARS-CoV-2 RBD reducing regulatory sequence regulatory sequences respiratory S protein S proteins SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S protein selected serological serological test Serological tests severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signal peptide subunit Subunit vaccine the S protein transfected cells translation unique Vaccine variant Viral viral envelope viral signal was obtained [DOI] 10.1371/journal.pone.0242890 PMC 바로가기 [Article Type] Research Article
The first 8 weeks of the Austrian SARS-CoV-2 epidemicOriginal Article Published on 2021-02-012022-10-29 Journal: Wiener Klinische Wochenschrift [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval acute respiratory syndrome age Anxiety Austria avoidance calculated consequence coronavirus COVID-19 death Depression Epidemic epidemiological Evidence exceeded expected group Health hygiene Impact Infection initial introduced lockdown measure Measures media men mental health Older pandemic Posttraumatic Stress Psychiatric Public public health measure public health measures reached reduce Relative risk Research Result RRs SARS-CoV-2 epidemic SARS-CoV‑2 Sex spread of COVID-19 Symptom was performed women [DOI] 10.1007/s00508-020-01804-9 PMC 바로가기 [Article Type] Original Article
Hospital bed capacity and usage across secondary healthcare providers in England during the first wave of the COVID-19 pandemic: a descriptive analysisHealth Policy Published on 2021-01-262022-10-28 Journal: BMJ Open [Category] Coronavirus, [키워드] college COVID-19 COVID-19 pandemic cumulative Descriptive analysis distribution Emergency England exceeded First wave Health policy Healthcare provider hospital improvement increase in independent intensive & critical care mechanical ventilation median Medicine National NHS objective outcome measure pandemic participant public health reached Result secondary care setting threshold ventilator [DOI] 10.1136/bmjopen-2020-042945 PMC 바로가기 [Article Type] Health Policy
CSF3 Is a Potential Drug Target for the Treatment of COVID-19Physiology Published on 2021-01-222022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] A549 analyzed antiviral drug bronchial organoid bronchial organoids Calu3 cell line COVID-19 CSF3 cumulative dataset death DEGs differentially expressed gene docking downloaded drug drug target drugs targeting Elbasvir epithelial cell line exceeded expression flexible Genes GSE147507 help identify infected with SARS-CoV-2 Infection inhibited Interaction lung adenocarcinoma mechanism MOE NHBE pathogenic pathway Potential PPI Prevent protein expression Protein–protein interaction receptor Research residue respiratory infectious disease Ritonavir screened significantly target therapeutic treat uninfected upregulated Vaccines van der Waal virus [DOI] 10.3389/fphys.2020.605792 PMC 바로가기 [Article Type] Physiology
Optimising Vaccine Dose in Inoculation against SARS-CoV-2, a Multi-Factor Optimisation Modelling Study to Maximise Vaccine Safety and EfficacyArticle Published on 2021-01-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Accuracy Ad5 adenovirus-vectored vaccines adverse event calibrated can be used COVID-19 Critical Developing dose dose dynamics dose-dependent Dose-response Dosing Efficacy and safety estimates exceeded global pandemic identify Immunity IMPROVE in viral induce inoculation less optimal dose Optimising Particle recombinant adenovirus required Research Result Safety SARS-CoV-2 SARS-CoV-2 vaccine Seroconversion statistical model Vaccine viral particle Viral particles [DOI] 10.3390/vaccines9020078 PMC 바로가기 [Article Type] Article
A survey of US hospitals’ criteria for the allocation of remdesivir to treat COVID-19미국 병원의 코로나19 치료제 렘데시비르 할당 기준 조사Multicenter Study Published on 2021-01-222022-09-11 Journal: American journal of health-system pharmacy : AJHP [Category] 치료제, [키워드] approved Care clinical Clinical course college Community Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic criteria determine develop distribution email Emergency use authorization Ethics EUA evaluated exceeded Guidance Health Health care health care rationing/ethics hospital indicated Infectious disease Infectious diseases initial Laboratory parameters majority network Pandemics parameter Patient patient identification patients with COVID-19 Pharmacy physician Physicians Practice random Remdesivir reported representing required resource Resource allocation respiratory status scoring system supply the United State treat Treatment treatment allocation United States [DOI] 10.1093/ajhp/zxaa391 PMC 바로가기 [Article Type] Multicenter Study
Untying the Precise Impact of COVID-19 Policy on Social Distancing BehaviorArticle Published on 2021-01-212022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] absence adopted antiviral drugs Behavior COVID-19 Effect effective Efficacy examined exceeded globe Google Government healthcare Impact influences interactions magnitude mechanism Novel coronavirus outcome pandemic Policies Policy reducing released Research respond social distancing Strong Vaccine was used [DOI] 10.3390/ijerph18030896 PMC 바로가기 [Article Type] Article
Nowcasting and Forecasting the Spread of COVID-19 and Healthcare Demand in Turkey, a Modeling StudyPublic Health Published on 2021-01-202022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] attack rate carried Compliance COVID-19 COVID-19 Modeling COVID-19 simulation death deaths Demand dimensions distribution epidemic forecasting Epidemics evaluate the effect exceeded expected Forecasting Healthcare system Hospitalization ICU Intervention mathematical modeling measure modeling Mortality non-ICU NPI number of infected predict predicted prediction prevented Support Turkey TURKSAS [DOI] 10.3389/fpubh.2020.575145 PMC 바로가기 [Article Type] Public Health