Retrospective cohort study to evaluate medication use in patients hospitalised with COVID-19 in Scotland: protocol for a national observational study스코틀랜드에서 COVID-19로 입원 한 환자의 약물 사용을 평가하기위한 후 향적 코호트 연구 : 국가 관찰 연구를위한 프로토콜Pharmacology and Therapeutics Published on 2021-11-192022-09-10 Journal: BMJ Open [Category] Fulltext, MERS, SARS, 치료제, [키워드] Administered Analysis approval board caused changes in choice clinical pharmacology clinical trials cohort study Committee COVID-19 death described description Dexamethasone dissemination Dose escalation drug East estimation Ethics evaluate Evidence example exploratory exposure to finding FIVE hospital hospitalisation hospitalisations hospitalised In-hospital Infection information knowledge medication Medicine Medicines National outcomes Panel Patient peer-reviewed platform Prevent Primary outcome privacy protocol Public real-world data receiving reduced risk Release Remdesivir Repurposed drug Research Ethics retrospective cohort study routine clinical practice SARS-COV-2 infection Scottish service severe COVID-19 South Surveillance switching Therapeutics Tocilizumab treated Treatment Vaccine website with COVID-19 [DOI] 10.1136/bmjopen-2021-054861 PMC 바로가기 [Article Type] Pharmacology and Therapeutics
Persistence of SARS-CoV-2-Specific Antibodies for 13 Months after Infection감염 후 13 개월 동안 SARS-COV-2- 특이 적 항체의 지속성Article Published on 2021-11-192022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody Antibody Response Antibody responses Asymptomatic COVID-19 vaccines declined Dynamics exposure to First wave IgG IgG and IgM IgG ELISA IgG level IgG levels IgG/IgM dynamics IgM individual infected individual Infection investigated Lithuania longitudinal study majority Month outbreak pandemic Reinfection remained S protein SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody second wave serological monitoring serological test Serological testing seropositive individual seropositive individuals Seropositivity Severity of infection specific antibodies specific IgM virus-specific antibodies Virus-specific IgG worker [DOI] 10.3390/v13112313 PMC 바로가기 [Article Type] Article
Case study: risk associated to wearing silver or graphene nanoparticle-coated facemasks for protection against COVID-19사례 연구 : COVID-19로부터 보호하기 위해은 또는 그래 핀 나노 입자 코팅 된 페이스 마스크를 착용하는 것과 관련된 위험Nanotoxicology Published on 2021-11-162022-09-10 Journal: Archives of Toxicology [Category] MERS, SARS, 치료기술, 치료제, [키워드] addition approach Chronic exposure coating COVID-19 database derivation effective exposure to facemask facemasks genotoxicity Grapheme Graphene Infection mandatory no effect pandemic Prevent prophylactic measure prophylactic measures repeated risk Risk assessment Safe SARS-CoV-2 virus silver silver nanoparticle Silver nanoparticles toxicokinetics [DOI] 10.1007/s00204-021-03187-w PMC 바로가기 [Article Type] Nanotoxicology
Deciphering the Role of Humoral and Cellular Immune Responses in Different COVID-19 Vaccines—A Comparison of Vaccine Candidate Genes in Roborovski Dwarf Hamsters상이한 CovID-19 백신에서 체액 및 세포 면역 반응의 역할을 해독하는-Roborovski Dwarf 햄스터에서 백신 후보 유전자 비교Article Published on 2021-11-162022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] adenoviral vector adenoviral vectors animal model Antigen candidate cellular immune responses compensated COVID-19 dwarf dwarf hamster Efficacy epitope Epitopes Evolution exposure to facilitate focus full-length full-length spike protein glycoprotein hamster immune response immune responses immunogenicity impairing Inactivated Vaccines membrane protein Mutation Neutralizing antibodies neutralizing antibody new SARS-CoV-2 nucleocapsid protein other SARS-CoV-2 genes prevented protective effect Protective effects provided question RBD Receptor binding domain response risk robust role SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 genes SARS-CoV-2 vaccine SARS-CoV-2 variants selected severe pneumonia Spike protein spike-based vaccines Spread susceptible T-cell Response the spike protein triggered Vaccine Vaccine design vaccine genes Vaccines variants virus replication [DOI] 10.3390/v13112290 PMC 바로가기 [Article Type] Article
Role of the Media in Health-Related Awareness Campaigns on Perception of COVID-19: A Pre-post Study in the General Population of PakistanCOVID-19 인식에 대한 건강 관련 인식 캠페인에서 미디어의 역할: 파키스탄의 일반 인구에 대한 사후 연구Public Health Published on 2021-11-122022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 치료기술, [키워드] Administered Awareness Characteristics Community community education conducted confirmed case country COVID-19 COVID-19 pandemic COVID-19 symptom COVID-19 symptoms electronic media Evidence exposure to Frequency General population greater Health health communication Health Education indicate Infection Isolation knowledge media participant Perception Population Prevent preventive measure preventive measures public health Quantitative quarantine questionnaire reported role SARS-CoV-2 significantly Society Spread [DOI] 10.3389/fpubh.2021.779090 PMC 바로가기 [Article Type] Public Health
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2기존의 중합효소 특이적 T 세포가 혈청 음성 반응을 일으키지 않는 SARS-CoV-2에서 확장Article Published on 2021-11-102022-09-10 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] abortive infection accumulate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody binding Cell clades clearance of SARS-CoV-2 Cohort complex conserved contribute Coronaviridae coronavirus Coronavirus infection Coronavirus infections cross-protective detectable develop Endemic epitope expand exposure to HCoV HCW HCWs healthcare worker highlight IFI27 Immunological memory in vivo increase in individual Infection memory response memory T memory T cell Neutralization assay neutralization assays pandemic PCR refs Region Replication respiratory response responses RNA polymerase robust RTC SARS-CoV-2 SARS-COV-2 infection seasonal coronavirus Sequence conservation Seroconversion seronegative severe acute respiratory syndrome Coronavirus subclinical infection Support T cell T cells target targets tested the strongest these cell These cells transcribed Transcription Vaccine variant Viral viral control [DOI] 10.1038/s41586-021-04186-8 PMC 바로가기 [Article Type] Article
A cross-sectional investigation of SARS-CoV-2 seroprevalence and associated risk factors in children and adolescents in the United StatesSARS-COV-2 혈청 유병률 및 미국의 어린이 및 청소년의 관련 위험 요인에 대한 단면 조사Research Article Published on 2021-11-082022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료법, [키워드] Analysis analyzed anti-SARS-CoV-2 antibody Antibody testing Antigen antigens Blood children concordance rate COVID-19 COVID-19 infection COVID-19 mitigation COVID-19 symptoms cross-sectional demographic determined by disease transmission enrolled evaluated exposure to Factor had no Health Hispanic ethnicity information Logistic regression much higher multivariate logistic regression no symptoms nucleocapsid observational study pandemic positive Receptor binding domain reported response Result risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 seroprevalence SARS-CoV-2 spike protein secondary seropositive Seropositivity specific antigen Spike protein symptoms of COVID-19 the United State vaccination Virginia was collected was performed with COVID-19 [DOI] 10.1371/journal.pone.0259823 PMC 바로가기 [Article Type] Research Article
COVID-19 in B Cell-Depleted Patients After Rituximab: A Diagnostic and Therapeutic Challenge리툭시 맙 후 B 세포 고갈 된 환자의 Covid-19 : 진단 및 치료 문제Review Published on 2021-11-032022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] adaptive Adaptive immunity Affect anti-CD20 anti-CD20 therapy anti-CD20 treatment anti-SARS-CoV-2 anti-SARS-CoV-2 monoclonal antibodies Antiviral treatment association Autoimmune disorders B cell B cell immunodeficiency B cell-depletion challenge Course COVID-19 deficiencies diagnostics disease Effect exposure to function hematologic hyperimmune convalescent plasma immune Immunity Immunotherapy Impact Interpretation involved long term malignancies Measures Musculoskeletal Protective rituximab SARS-CoV-2 SARS-COV-2 infection serological significantly Therapeutic approach therapeutic strategy vaccine responses variety [DOI] 10.3389/fimmu.2021.763412 PMC 바로가기 [Article Type] Review
Immune Response of Neonates Born to Mothers Infected With SARS-CoV-2SARS-CoV-2에 감염된 산모에게서 태어난 신생아의 면역 반응Observational Study Published on 2021-11-032022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] 48 hour 48 hours age antibody antibody production arbitrary unit association Birth breastmilk children Clinical outcome cohort study enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated explain exposure exposure to finding Follow-up gestational age IgA IgA antibodies IgA antibody IgG antibodies IgM antibodies IgM antibody immune complex Immune complexes immune response immune responses immune system Importance in utero Infant Infants infected with SARS-CoV-2 Infection infection with SARS-CoV-2 information investigated IQR Italy life male Maternal maternal age measure mother mucosal mucosal immune Neonatal Neonate Newborn objective occurred offspring participant parturition passive immunity Point positive Pregnancy pregnant women prospective cohort study PROTECT provided Receptor binding Receptor binding domain Relevance response Result Rome Saliva salivary SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike secretory IgA serum setting significantly higher significantly increased specific antibodies specific antibody specific IgG antibodies spike-specific antibodies Spike-specific antibody spike-specific IgG stimulate systemic immune response systemic immune responses tested transfer Transmission Umberto vertical transmission vertical virus transmission virus Virus spike virus transmission [DOI] 10.1001/jamanetworkopen.2021.32563 PMC 바로가기 [Article Type] Observational Study
Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study영국의 SARS-CoV-2 계통 B.1.1.7과 관련된 사망률 및 중환자실 입원: 관찰 코호트 연구Observational Study Published on 2021-11-012022-09-10 Journal: The Lancet. Infectious Diseases [Category] MERS, SARS, 변종, 임상, [키워드] 28-day mortality 95% CI adjusted adjusted hazard ratio adjusted hazard ratios Admission age association Asthma Audit B.1.1.7 body-mass body-mass index cardiovascular disease case mix CCU chronic obstructive chronic obstructive pulmonary disease Clinical outcome clinical outcomes Cohort Community Comorbidities Comorbidity COVID-19 test COVID-19 testing Critical care Critically ill dependency Deprivation diabetes diagnostic died division Ethnicity exposure to finding funding geographical region groups hazard ratios hospital HRs hypertension immunocompromised condition increased risk independent independent of Infection infection with COVID-19 information Lineage Lineage B.1.1.7 measure Medical Science metastatic disease molecular Mortality National Observational cohort study obstructive pulmonary disease on type on types organ support overall mortality Oxford Patient patients with SARS-CoV-2 positive positive sample primary care Public Health England pulmonary disease QResearch receiving reported respiratory Respiratory disease risk S-gene SARS-CoV-2 SARS-COV-2 infection Sex smoking status Sociodemographic factor the SARS-CoV-2 two groups University of Oxford variant variant of SARS-CoV-2 virus strain Wellcome Trust [DOI] 10.1016/S1473-3099(21)00318-2 PMC 바로가기 [Article Type] Observational Study