The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral DefenseSARS-CoV-2의 돌연변이 프로필은 주로 숙주 항바이러스 방어에 의해 형성됩니다Article Published on 2021-03-022022-09-10 Journal: Viruses [Category] SARS, 변종, 유전자 메커니즘, [키워드] ADAR Antiviral APOBEC approach contribute COVID-19 COVID-19 pandemic effort event Evolution Genome genomes heterogeneous Host independent independent of mechanism Mutagenesis Mutation number of infected oxygen Phylogenetic tree phylogenetics profile Proteins reactive oxygen species reference genome ROS SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genomes SARS-CoV-2 isolates understanding virus virus genome virus genomes ZAP [DOI] 10.3390/v13030394 PMC 바로가기 [Article Type] Article
Introduction into the Marseille geographical area of a mild SARS-CoV-2 variant originating from sub-Saharan Africa: An investigational study사하라 사막 이남의 아프리카에서 기원한 온화한 SARS-CoV-2 변종의 마르세유 지리적 지역 소개: 조사 연구Article Published on 2021-03-012022-09-11 Journal: Travel medicine and infectious disease [Category] SARS, 변종, 치료기술, [키워드] addition characterized China clade clinical feature Combination COVID-19 COVID-19 incidence COVID-19 patient COVID-19 patients disease Epidemic Europe France French Genes Genome genome sequence Genome sequences genomes infecting involved Maghreb Marseille Marseille-1 Mild Mutation North Nsp12 NSP2 Nsp3 ORF3a ORF8 outbreak Outbreaks Patient qPCR reached remained SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant sequenced significantly Strains suggested transferred Travel Univariate analysis variant Viral viral variant virus [DOI] 10.1016/j.tmaid.2021.101980 PMC 바로가기 [Article Type] Article
Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents주요 변이체 표면 항원 암호화 유전자의 진화적 분석은 대륙 내 및 대륙 간 열원충의 개체군 구조를 나타냅니다.Research Article Published on 2021-02-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] absence Analysis Antigen approach asked biological significance complexity conserved country dataset deep sequencing demonstrated detect diagnostic Disease surveillance Diversity DNA DNA sequence DNA sequences domain East effort ENCODE Epidemics Evolution Gabon genomes Globalization health problem hidden hidden markov model HIV Host identify identity immunodominant implication infect Influenza isolate Local malaria malaria parasite malaria parasites Markov methodology Microbiologist MOST outcome parasite parasites pathogen Pathogens Plasmodium Plasmodium falciparum population immunity precluded presence or absence public health recent Recombination sensitivity sequence South America Spread subsequent surface antigen Surface Antigens Surveillance tested to define translational Transmission dynamics Uganda unique VAR var gene var genes variant variants West [DOI] 10.1371/journal.pgen.1009269 PMC 바로가기 [Article Type] Research Article
Next-generation diagnostics: virus capture facilitates a sensitive viral diagnosis for epizootic and zoonotic pathogens including SARS-CoV-2Methodology Published on 2021-02-202022-10-29 Journal: Microbiome [Category] COVID-19, Fulltext, 조류인플루엔자, [키워드] Abstract African approach biotinylated Capture enrichment Combination Complete complex conducted conserved cross-contamination Diagnosis diagnostic Diagnostic tool diagnostics DNA and RNA Ebolavirus event extension facilitate Fever Generic Genome genome regions genomes Health identity information library Metagenomics virus detection outbreak pathogen Proficiency test related virus related viruses Research question Result Rift risk RNA RNA baits SARS-CoV-2 sensitivity sequenced Sequencing sequencing depth shown supplementary material Support tested Valley viral genome VirBaits 1.0 virus virus detection viruses zoonotic zoonotic pathogen [DOI] 10.1186/s40168-020-00973-z PMC 바로가기 [Article Type] Methodology
Global Geographic and Temporal Analysis of SARS-CoV-2 Haplotypes Normalized by COVID-19 Cases During the PandemicMicrobiology Published on 2021-02-172022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] age analyzed approach Asia available data characterized circulating country COVID-19 COVID-19 case distribution Epidemiology Europe Evolution FIVE functional Gender Genome genomes Geographic global analysis Haplotype haplotypes help hypothese identify Isolation major haplotype major haplotypes Mutation mutations nine North America NSP2 Oceania operational taxonomic units pathogenicity Patient phylogenomic Region relative frequency reported SARS-CoV-2 sequenced sequenced genome South America T85I Temporal Transmissibility unique viral pandemic virus [DOI] 10.3389/fmicb.2021.612432 PMC 바로가기 [Article Type] Microbiology
Early Diffusion of SARS-CoV-2 Infection in the Inner Area of the Italian Sardinia IslandMicrobiology Published on 2021-02-122022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome addition affected amino acid substitution amino acid substitutions Analysis Area clinical sample Cluster Complete coronavirus coronavirus disease COVID-19 death early phase eight epidemiological Epidemiology European country genetic diversity Genome sequencing genomes genomic geographical distribution homogeneous hospital incidence Infection information initial Inner island Italian Italian patient Italy Local lowest molecular characterization outbreak pandemic Phylogenetic Phylogeny Prevalence provide Region reported responsible Result Sardinia Sardinia Island SARS-CoV-2 SARS-CoV-2 viral sequence Sequencing severe pneumonia the SARS-CoV-2 viral genome was performed Wuhan, China [DOI] 10.3389/fmicb.2020.628194 PMC 바로가기 [Article Type] Microbiology
Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene ExpressionReview Published on 2021-02-022022-10-31 Journal: Cells [Category] COVID-19, MERS, [키워드] activity acute respiratory syndrome Amino acid antiviral responses biological function cell interaction cellular cleavage contribute Control Coronaviruses CoVs disrupt endonucleolytic cleavage evade function Gene Expression genomes highly pathogenic Host host gene expression host gene expression suppression host mRNA human coronavirus identity involved mechanism MERS-CoV Middle East mRNA mRNA degradation nonstructural protein 1 nsp1 pathogenic SARS-CoV SARS-CoV-2 suppresse syndrome translation translational suppression viral mRNA viral pathogenicity Viral protein viral replication virulence virulence factor virus virus pathogenesis [DOI] 10.3390/cells10020300 PMC 바로가기 [Article Type] Review
Isolating SARS-CoV-2 Strains From Countries in the Same Meridian: Genome Evolutionary AnalysisOriginal Paper Published on 2021-01-222022-10-29 Journal: Jmir Bioinformatics and Biotechnology [Category] COVID-19, [키워드] 3D Structures acting affected Algorithm analyses Analysis analyzed Antiviral strategies approach Asia average binding binding probability Brazil caused change characterized clade clinical feature codon codon mutation Codons conditions country COVID-19 death Effect ENCODE ENhance epidemiological episodic selective pressure eukaryotic cells Europe Evolution Evolutionary analysis facilitate Genetic genetics Genome genomes genomic glycine help in vitro experiment initiative Isolating Italy Modification mutated Mutation North America objective ontological Ontology performed Phylogenetic tree positioned predict predicted prediction pressure Probability Protein Recombination reported Repository respiratory infection responsible Result RNA secondary structure SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain secondary structure selective sequence shown similarity strain Structure to define transmembrane transmembrane region turn Vaccine design virus Virus evolution wild-type [DOI] 10.2196/25995 PMC 바로가기 [Article Type] Original Paper
A protocol for adding knowledge to Wikidata: aligning resources on human coronavirusesWikidata에 지식을 추가하기 위한 프로토콜: 인간 코로나바이러스에 대한 리소스 정렬Methodology Article Published on 2021-01-222022-09-10 Journal: BMC Biology [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] added aligned aligning applicability applied automated automatically bases Biotechnology can be used caused center commons coronavirus COVID-19 COVID-19 pandemic defined demonstrated example Genome genomes help helping HKU1 human coronavirus human coronavirus 229E integration knowledge knowledge bases Knowledge graph Linked data MERS NCBI new virus NL63 Open Science pandemic platform problems proteome proteomes protocol related virus related viruses required resource Result SARS-CoV-2 pandemic SARS-CoV-2 virus shape ShEx taxonomy the SARS-CoV-2 the SARS-CoV-2 virus UniProt unique viruses Wikidata Wikipedia [DOI] 10.1186/s12915-020-00940-y PMC 바로가기 [Article Type] Methodology Article
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus서아프리카 Anopheles의 pirimiphos-methyl에 대한 내성은 Ace1 유전자좌의 복제 및 유전자이입을 통해 확산되고 있습니다.Research Article Published on 2021-01-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] ACE1 acetylcholinesterase African Analysis Anophele Anopheles gambiae approach association Carbamate Combination complex Control copy number diagnostic dominant driven by duplication duplications effective Effectiveness enzyme Genetic genomes genomic Haplotype highlight increasingly insecticidal insecticide insecticides Intervention locus malaria malaria vector molecular Mutation Non-synonymous occur organophosphate overcome phenotypic pirimiphos-methyl Population populations Predictive Predictive value predictor Prevent provide public health reduce Replication resistance resistance mechanism resistance mechanisms selection pressure sequenced specimen Spread sub-Saharan Africa Surveillance transferred Transmission unique Variation vector vectors West whole genome [DOI] 10.1371/journal.pgen.1009253 PMC 바로가기 [Article Type] Research Article