Bioactive Indolyl Diketopiperazines from the Marine Derived Endophytic Aspergillus versicolor DY180635Article Published on 2020-06-282022-10-30 Journal: Marine Drugs [Category] COVID-19, SARS, [키워드] Analysis Aspergillus Aspergillus versicolor Chiromantes haematocheir Compound Corona coronavirus coronavirus 2 COVID-19 Culture diketopiperazine diketopiperazines docking score ECD ECD calculation enantiomers endophyte fungus High-resolution MPro NMR nuclear protease respiratory SARS-CoV-2 screened selected Structure versicolor Virtual screening [DOI] 10.3390/md18070338 PMC 바로가기 [Article Type] Article
Effect of hydroxychloroquine on COVID-19 prevention in cancer patients undergoing treatment: a structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-262022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 Acute Lymphoid Leukemia acute myeloid leukemia age anticipated approval approved assigned blinded blocks Breast cancer calculated Cancer cancer patient cardiac disease chemotherapeutic agent chronic pulmonary disease clinical Colon cancer company Computed tomography control group cough COVID-19 COVID-19 symptom curative intent data analyst disease dissemination Effect element examined exclusion criteria Fever FIVE follow-up period High-resolution Hydroxychloroquine IgG antibody incidence of COVID-19 include Intervention investigated Iran leukemia Lungs lymphoid lymphoma Mashhad Medical Sciences novel nucleic acid amplification number objective occur outcome parallel-group participant Patient patients performed pharmaceutical Placebo primary end point produced Prophylaxis protocol randomised randomised controlled trial randomization sequence Randomly randomly permuted blocks recruitment Registered registration date registry respiratory tract infection Sample size sensitivity Shortness of breath specific IgM status Study protocol Symptom Tablet the patient the SARS-CoV-2 virus total sample size treated Treatment Trial triple-blind two group Two-arm university website [DOI] 10.1186/s13063-020-04485-x PMC 바로가기 [Article Type] Letter
Oropharyngeal Dysphagia and Aspiration Pneumonia Following Coronavirus Disease 2019: A Case ReportLetter Published on 2020-06-122022-10-31 Journal: Dysphagia [Category] COVID-19, MERS, [키워드] acute respiratory syndrome aspiration aspiration pneumonia contractile coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cranial nerve Deglutition Deglutition disorder dysfunction Dysphagia elicited High-resolution knowledge male neurologic Oropharyngeal outbreak pandemic Patient report sense of taste severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe respiratory infection silent subsequent suggested vagus nerve with COVID-19 [DOI] 10.1007/s00455-020-10140-z PMC 바로가기 [Article Type] Letter
Efficacy and safety of Anluohuaxian in the treatment of patients with severe Coronavirus disease 2019- a multicenter, open label, randomized controlled study: a structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-082022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 6-minute walking distance actual Alpha analyst Anluohuaxian antiviral drugs brand bronchial asthma Care change changes Chinese Chinese herbal medicines chronic obstructive Colchicine Combined completion Compliance composed computer tomography Confirmed connective tissue control group Coronavirus disease 2019 COVID-19 criteria Cyclophosphamide cytokine diagnosed dissemination distribution drug Efficacy and safety element Endocrine enrolled Estimated evaluate expected experimental group explained facilitate fibrosis glucocorticoid groups hepatic fibrosis High-resolution history Hormones HRCT Huoshenshan Hospital Imatinib include indicate interferon-γ interstitial Interstitial lung disease investigators involved IWRS Kidney disease lactating liver lobular lung maximum Mental Disorders minimum multicenter Nasopharyngeal swab Necrosis negative neurologic Nintedanib nodule not blinded nucleic acid test number objective open label outcome outcome assessors participant Participants Pathogenesis pathway Patient pharmaceutical pill professional proportion protocol provided pulmonary pulmonary disease pulmonary fibrosis random randomised randomised controlled trial randomization randomization system Randomized Randomized controlled trial randomly divided RCT recruitment Research research drug respiratory specimen Sample size Science second selected severe COVID-19 sputum statistical status Study protocol subject technology therapeutic drug Tongji Hospital treated Treatment treatment group Trial Union Hospital university variety website West Wuhan Year [DOI] 10.1186/s13063-020-04399-8 PMC 바로가기 [Article Type] Letter
Aerosolized Particle Reduction: A Novel Cadaveric Model and a Negative Airway Pressure Respirator (NAPR) System to Protect Health Care Workers From COVID-19Research Articles Published on 2020-05-192022-10-29 Journal: Otolaryngology--Head and Neck Surgery [Category] Coronavirus, MERS, SARS, [키워드] aerosol Airway Pressure applied cadaver calculate conditions coronavirus disease COVID-19 creating described Digital image processing effective Efficacy escaped evaluate fixed Health care worker High-resolution identify Laboratory lower airways Mask Masks methodology Model negative novel objective Particle Particles pressure PROTECT Respirator Result rhinology setting Significant skull base smoke Spread stick suction surgical System tissue Transmission Trial variety was performed was used worker [DOI] 10.1177/0194599820929275 PMC 바로가기 [Article Type] Research Articles
Copy number variants and fixed duplications among 198 rhesus macaques ( Macaca mulatta )198마리의 붉은털 원숭이( Macaca mulatta ) 사이의 복제 수 변종 및 수정된 중복Research Article Published on 2020-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] assumption Biomedical research chromosome composed concerning conducted copy copy number copy number variant Copy number variants dataset design of experiments disease risk distribution duplication duplications event Evolution experiment fixed focus functional consequences genetic difference genetic differences Genetic variation Genome genomes genomic genomic region high resolution High-resolution highlight human disease humans individual individuals inter-individual knowledge large sample Old World monkey Old World monkeys one individual organism Organisms orthologs performed Phylogenetic relationship profile reference genome Region regions representing Research rhesus rhesus macaque rhesus macaques sequence similarity species target gene Target genes variable regions Variation [DOI] 10.1371/journal.pgen.1008742 PMC 바로가기 [Article Type] Research Article
The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion ConformationStructure and Assembly Published on 2019-09-182022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] alphacoronavirus spike antigens betacoronaviruses biological processe cause concerning conformation conformational Cryo-electron microscopy cryo-EM described domain effort epidemic diarrhea facilitate glycoprotein glycosylated heterogeneity high mortality rate High-resolution host cells host immune responses IMPROVE in viral Infection information Like macromolecular membrane fusion molecular mechanism N terminus Neonatal NL63 observation other coronaviruses pathogenic PEDV prefusion conformation Receptor binding receptor engagement Receptor-binding domain reveal S protein S1 subunit S1-CTD spike Spike protein Spike proteins Stage Structure subunit the S1 subunit the spike protein These data triggering trimer trimeric spike Vaccine Vaccines virus [DOI] 10.1128/JVI.00923-19 PMC 바로가기 [Article Type] Structure and Assembly
Comparative Analysis of Gene Expression in Virulent and Attenuated Strains of Infectious Bronchitis Virus at Subcodon ResolutionGenome Replication and Regulation of Viral Gene Expression Published on 2019-06-262022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] Analysis avian coronavirus Cell cellular changes in chick coding region Comparative complex conserved Coronaviruses data set Differential gene expression differentially expressed downstream Efficiency expand facilitated form Frame Gene Expression gene network generate Genome genomic RNA High-resolution host cell response host genes IBV IBV infection Improved include indicated Infection Infectious Bronchitis Virus isolates kidney Like Molecular biology mRNA transcript nucleocapsid occur ORF ORF4b pathogen pathogenic positive-sense quantification Replication Resolution ribosome profiling RNA genome RNA virus RNAseq Sequencing sgmRNA sgmRNA transcripts sgmRNAs Single nucleotide polymorphism single-stranded Spread strain Strains subgenomic mRNA Transcription translation translational Triplet upregulation Vaccination strategy vaccine candidate Variation viral RNA synthesis virus virus infection [DOI] 10.1128/JVI.00714-19 PMC 바로가기 [Article Type] Genome Replication and Regulation of Viral Gene Expression
Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania심각한 말라리아 및 탄자니아 북동부의 선택적 압력과 관련된 새로운 유전적 다형성Research Article Published on 2018-01-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] acquisition African allele frequencies allele frequency analyses approach association caused Cell characterisation chromosome chromosome 4 Cohort country dataset Endemic Evidence evidence of expected extended haplotype Factors Frequency GCLC gene mutation gene target Genetic genetic factors genetic mutation genetic mutations Genetic polymorphism Genome Genome-wide association studies Genome-wide association study genomes genotyping GWAS haplotypes HbS High-resolution histocompatibility Host Human genome human population human populations identification identify immunological pathways imputation independent Intervention joint KLHL3 linkage loci Major major histocompatibility complex malaria malarial disease mechanism MHC molecular morbidity Mortality natural selection novel parasites performed Phenotypes phenotypic phenotypic variation Plasmodium falciparum Plasmodium falciparum infection polymorphism Population Positive selection Protective Protein Rare variants receptor reduced risk Region Research resulting risk factor selection pressure selective Sequencing severe malaria sickle cell sickle cell trait Significant significant effect SNPs Structural variant structural variants sub-Saharan Africa susceptibility susceptibility loci SYNJ2BP target variant Variation whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1007172 PMC 바로가기 [Article Type] Research Article
High-resolution MRI vessel wall imaging in varicella zoster virus vasculopathy수두대상포진 바이러스 혈관병증에서 고해상도 MRI 혈관벽 영상 촬영Case Reports Published on 2015-04-152023-05-31 Journal: Journal of the neurological sciences [Category] 대상포진, 두창, 수두, 홍역, [키워드] angiography High-resolution MRI Treatment Varicella zoster virus Vasculopathy [DOI] 10.1016/j.jns.2015.02.017 PMC 바로가기 [Article Type] Case Reports