Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registryResearch article Published on 2022-03-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] age Chronic kidney disease cohort of patient Comorbidity controls Course COVID-19 COVID-19 diagnosis D-dimer level diagnosed disease Epidemiology females hospital hospitals Hypothyroid Hypothyroidism in-hospital mortality management matching mechanical ventilation median age Mortality number of comorbidities outcome Paired analysis Patient patients with COVID-19 Prevalence Prognosis Result Sex Thyroid was performed worse prognosis [DOI] 10.1016/j.ijid.2022.01.016 [Article Type] Research article
Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled TrialClinical Trial Published on 2022-03-012022-10-05 Journal: Chest [Category] SARS, 임상, [키워드] activated alteplase ARDS baseline benefit bleeding event Brain Combination control group Controlled COVID-19 cross-sectional early administration eight Enrollment failure fibrinolysis Hemorrhagic IMPROVE Improvements improvements in oxygenation in-hospital mortality IQR maintain mechanism microthrombi Mortality neurologic observation occurred outcome Participants Patient patients Phase 1 Phase 2 phase 3 study Primary outcome pulmonary pulmonary failure Pulmonary function randomization Randomized receiving respiratory Respiratory failure Safe SARS-CoV-2 secondary severe COVID-19 significantly Standard-of-care statistically significant difference stroke therapeutic tissue plasminogen activator Tissue plasminogen activator (tPA) Treatment Vascular ventilator-free day VFD were excluded [DOI] 10.1016/j.chest.2021.09.024 PMC 바로가기 [Article Type] Clinical Trial
Usefulness of Combined Renin-Angiotensin System Inhibitors and Diuretic Treatment In Patients Hospitalized with COVID-19Research article Published on 2022-03-012022-10-05 Journal: The American journal of cardiology [Category] SARS, 변종, 치료법, [키워드] 95% confidence interval Admission age Alter antecedent cardiovascular disease Clinical deterioration Combined complications of COVID-19 concomitant medications Coracle discharge diuretic diuretics evaluate hospitalized patient in-hospital mortality in-hospital mortality rate indicated Infection inhibitor Italy Laboratory Logistic regression Mortality Odds ratio Patient patients patients hospitalized patients treated Prevent PROTECT reduced Region renin-angiotensin system risk System treated Treatment Uncertainty with COVID-19 [DOI] 10.1016/j.amjcard.2021.12.004 [Article Type] Research article
D-dimer, CRP, PCT, and IL-6 Levels at Admission to ICU Can Predict In-Hospital Mortality in Patients with COVID-19 PneumoniaResearch Article Published on 2022-02-282022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] age Belgrade Can center clinical Clinical outcome COVID-19 outbreak COVID-19 patients criteria Critically ill Critically ill patient CRP cutoff value D-dimer diagnosis of COVID-19 discharged disease effective female FEU for inclusion Health care hospital Hospitalization ICU identify IL-6 IMPROVE in-hospital death prediction in-hospital mortality intensive care unit Level log-rank test male management median age Mortality Patient patients died patients treated PCT predict predictor procalcitonin recognize Result retrospective cohort study ROC Curve statistically significant survival the Kaplan-Meier method Treatment was determined were used with COVID-19 [DOI] 10.1155/2022/8997709 PMC 바로가기 [Article Type] Research Article
Comparative outcomes of combined corticosteroid and remdesivir therapy with corticosteroid monotherapy in ventilated COVID-19 patientsResearch Article Published on 2022-02-232022-10-28 Journal: PLoS ONE [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 48 hour all-cause mortality all-cause mortality rate analyzed Clinical improvement Cohort cohorts combination therapy Comparative conducted Corticosteroid COVID COVID-19 COVID-19 patient COVID-19 patients Cox proportional hazard Critically ill Efficacy groups hazard Hospitalized IMPROVE in-hospital mortality incidence Infection infections Kaplan-Meier Length log-rank test LOS monotherapy MRSA network Observational cohort study on mechanical ventilation outcome oxygen support Patient Primary outcome propensity score matching Pseudomona PSM Ratio RDV reduce reducing Remdesivir requiring supplemental oxygen secondary significant decrease Staphylococcus aureus stratified survival therapy Ventilated ventilatory support with COVID-19 [DOI] 10.1371/journal.pone.0264301 PMC 바로가기 [Article Type] Research Article
Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial캐나다에서 COVID-19로 병원에 입원한 환자의 치료를 위한 Remdesivir: 무작위 대조 시험Randomized Controlled Trial Published on 2022-02-222022-09-11 Journal: CMAJ : Canadian Medical Association journal = jour [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 95% CI 95% confidence interval adverse event age Analysis assigned baseline Canada changes in Characteristics clinical outcomes Clinical severity conjunction Consent Controlled trial COVID-19 creatinine Data collection defined demographics dialysis duration of symptom Effect enrolment evaluated event followed by groups Health care health care systems Health Organization health systems hepatic dysfunction hospital Hospital mortality Hospital stay hospitals in-hospital mortality incidence intravenously mechanical ventilation mechanically ventilated Mortality no difference Open-label outcome oxygen Patient patients performed Pragmatic Primary outcome Randomized Randomized controlled trial randomized patient RCT receive receiving Relative risk Remdesivir risk secondary Secondary outcomes severity of symptom Sex significant effect solidarity Solidarity trial standard care Standard deviation Standard of care Standard-of-care Treatment Trial Trial registration ventilator-free day Ventilator-free days with COVID-19 World Health Organization [DOI] 10.1503/cmaj.211698 PMC 바로가기 [Article Type] Randomized Controlled Trial
High procalcitonin levels associated with increased intensive care unit admission and mortality in patients with a COVID-19 infection in the emergency department응급실에서 COVID-19 감염 환자의 집중 치료실 입원 및 사망률 증가와 관련된 높은 Procalcitonin 수준Research Article Published on 2022-02-212022-09-10 Journal: BMC Infectious Diseases [Category] COVID19(2023년), Fulltext, MERS, SARS, 바이오마커, [키워드] 105 patient 105 patients 95% CI 95% confidence interval acute respiratory distress acute respiratory distress syndrome adjusted Admission age Analysis ARDS assist association AUC Bacterial bacterial coinfections Biomarker Biomarkers C-reactive protein C-reactive protein (CRP calculate center clinical decision Comorbidities Comorbidity Confirmed COVID-19 infection COVID-19 COVID-19 infection COVID-19 infections CRP D-dimer Decision making decision making process defined develop elevated emergency department Erasmus Final final analysis hospital discharge Hospital mortality hyperinflammation ICU ICU admission in-hospital mortality intensive care intensive care unit Logistic regression Mortality multivariable model Netherlands Odds ratio outcome Patient patients with COVID-19 PCT physician Primary outcome procalcitonin procalcitonin level reached required respiratory distress Respiratory distress syndrome Result retrospective cohort study Severe COVID-19 Infection severe COVID-19 infections Sex significantly supplementary material syndrome were measured [DOI] 10.1186/s12879-022-07144-5 PMC 바로가기 [Article Type] Research Article
Use of proton pump inhibitors are associated with higher mortality in hospitalized patients with COVID-19Research Theme 1: COVID-19 Pandemic Published on 2022-02-192022-10-31 Journal: Journal of Global Health [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 95% confidence interval adverse effect adverse outcome Analysis Cohort coronavirus disease COVID-19 COVID-19 pandemic daily dose death defined dosage entire cohort hospital Hospitalization hospitalized patient In-hospital death in-hospital mortality Inconclusive inhibitor laboratory-confirmed Mortality multivariate logistic regression nucleic acid Odds ratio Patient patients older physician Pneumonia PPI remained reported Result risk SARS-CoV-2 Sensitivity analyses sensitivity analysis significantly Usage with COVID-19 [DOI] 10.7189/jogh.12.05005 PMC 바로가기 [Article Type] Research Theme 1: COVID-19 Pandemic
Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 PneumoniaBrief Report Published on 2022-02-172022-10-31 Journal: Geriatrics [Category] COVID-19, [키워드] acute respiratory distress Administered Admission age ARDS benefit Care Clinical outcome clinical outcomes Control corticosteroid therapy corticosteroid treatment Corticosteroids COVID-19 determine early phase ECT Effectiveness enrolled Escalation home home therapy Hospitalization Hospitalized ICU in-hospital mortality median no difference older patient older people pandemic PaO Patient Pneumonia progression progression of disease reducing SARS-COV-2 infection significant difference SOFA score subject syndrome systemic the disease transfer with COVID-19 [DOI] 10.3390/geriatrics7010021 PMC 바로가기 [Article Type] Brief Report
Remdesivir in combination with dexamethasone for patients hospitalized with COVID-19: A retrospective multicenter studyCOVID-19로 입원 한 환자를위한 덱사메타손과 함께 Remdesivir : 후 향적 다기관 연구Multicenter Study Published on 2022-02-172022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] 1:1 addition Admission Algorithm analyzed balance checked clinical benefit Combination COVID-19 pneumonia death death rate death rates Dexamethasone duration of hospitalization Hospital mortality Hospitalization hospitalized patient hospitalized patients In-hospital death in-hospital mortality Infectious disease Infectious diseases intensive care intensive care unit Logistic low-flow oxygen male Male sex matching mean differences median median time multivariable outcome oxygen Patient patients hospitalized patients with COVID-19 Pneumonia populations Primary outcome prognostic Propensity score receiving reduced Remdesivir replacement Result retrospective cohort study Retrospective multicenter study secondary Secondary outcomes Standard deviation Standard of care symptoms onset transfer Treatment was performed with COVID-19 [DOI] 10.1371/journal.pone.0262564 PMC 바로가기 [Article Type] Multicenter Study