Acquisition of Cell–Cell Fusion Activity by Amino Acid Substitutions in Spike Protein Determines the Infectivity of a Coronavirus in Cultured CellsResearch Article Published on 2009-07-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acid acquisition activity Amino acid bronchitis Cell cell line cells chimeric cloned compensatory mutation coronavirus cultured cell cultured cells determine determined ENhance expression fusion heptad repeat Host host cell IBV infectious Infectivity Interaction introduced kidney membrane fusion Mutation Point mutation Protein Region required responsible S gene S protein S1 domain shown site-directed mutagenesis specificity spike strain Substitution syncytia formation the S protein variant Vero Vero cells viral spike [DOI] 10.1371/journal.pone.0006130 PMC 바로가기 [Article Type] Research Article
Towards construction of viral vectors based on avian coronavirus infectious bronchitis virus for gene delivery and vaccine developmentArticle Published on 2009-05-042022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] approach avian coronavirus Avian coronavirus infectious bronchitis virus backbone Cell culture coronavirus demonstrated Dengue different Effect Embryo Express expression firefly luciferase gene fluorescent found Gene gene delivery Gene Expression Genome Host IBV infectious Infectious Bronchitis Virus inoculated intrinsic manipulation ORF6 Protein reverse genetics stability tissue Vaccine Vaccine development vector viral gene viral infection Viral vector virus viruses [DOI] 10.1016/j.jviromet.2009.04.023 PMC 바로가기 [Article Type] Article
Human immunopathogenesis of severe acute respiratory syndrome (SARS)Article Published on 2007-03-192022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Adaptive immune response cellular chemokine Clinical course Complete complex cytokine dysregulated hallmark Host host immune system host immunity host response Human human host hypercytokinemia IFN Immunity immunological Immunopathogenesis immunopathology Impact imperative Infected infectious Inflammatory response Injury Innate immunity interferon mechanism Microarray molecular morbidity Progressive Protective Research response resulting SARS SARS Coronavirus SARS CoV SARS patients severe pathology severe SARS suggested systematic analysis type I [DOI] 10.1016/j.virusres.2007.02.014 PMC 바로가기 [Article Type] Article
Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virusResearch Published on 2007-02-262022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] acute respiratory syndrome aminopeptidase N arch BHK-21 cell canine Cell cells chick compared coronavirus Coronaviruses Efficiency expression functional gastroenteritis GT HCoV-229E host cells host range human coronavirus 229E humans IBV identity Infected Infection infectious Infectious Bronchitis Virus Infectious disease Interaction kidney many cases mass Miguel notable receptor Result Strains suggested susceptibility susceptible TGEV transient transfection virus [DOI] 10.1186/1743-422X-4-20 PMC 바로가기 [Article Type] Research
Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape MutantsResearch Article Published on 2006-07-042022-10-29 Journal: PLoS Medicine [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome Administered affected against SARS-CoV Alter Amino acid anti-SARS-CoV antibody antibody antibody concentration Antigen antigens approach arising Bacteria binding blocked Blood breadth carried caused center China close contact close person-to-person contact Combination complementary Concentration Control convalescent SARS patient coronavirus Coverage CR3014 CR3022 died different disease disease severity dose Effect effective Epidemic Epidemics epitope escape experiment feasible ferret ferrets finding generate glycoprotein Guangdong Health healthy Hong Kong Human human cell human cells human macrophage Human monoclonal antibody humans immune Immune escape immunization immunize in vitro individual effects Infected infecting Infection infectious Infectious disease information interact Interaction International killing Laboratory less limit lung damage Lung pathology mAb mAbs measure monoclonal monoclonal antibody Mutation neutralization neutralized NO organism Patient pharyngeal Prevent prevented prevention producing Prophylaxis provided quarantine recognize recognizing reduce reduction repeated replicated required Research researcher residue responsible SARS epidemic SARS-CoV SARS-CoV infection screened shown sick Spread strain suppress synergistic synergistic fashion synergy tested the disease the receptor-binding domain Travel treat variant variants viral escape viral spread virus Virus neutralization virus strain virus-neutralizing viruses website Wikipedia World Health Organization [DOI] 10.1371/journal.pmed.0030237 PMC 바로가기 [Article Type] Research Article
Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory SyndromeResearch Article Published on 2006-05-182022-10-29 Journal: PLoS Medicine [Category] Coronavirus, MERS, [키워드] 2003 acute respiratory syndrome Adequate affected animal animal model cause caused changed Chest radiograph children clinical disease Clinical laboratory test clinically clone coronavirus cynomolgus macaque demonstrated develop disease effective vaccine Evidence finding group Health Infected Infection infectious intravenous intravenously Jason macaque majority Mild Model moderate mucosal route nare Neutralizing antibodies NHP NHPs parameter Pathogenesis peaked Pneumonia Postinfection produced required respiratory SARS-CoV SARS-CoV infection SARS-CoV Urbani severe significantly similarity symptomatic syndrome viral replication virus were infected wild-type [DOI] 10.1371/journal.pmed.0030149 PMC 바로가기 [Article Type] Research Article
Evidence of human coronavirus HKU1 and human bocavirus in Australian childrenArticle Published on 2005-10-272022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, [키워드] absence Acute respiratory tract disease aetiology age applied assay children compared contribute contributing to coronavirus described diagnoses diagnostic disease Epidemiology evidence of found Genetic HCoV-HKU1 HKU1 human bocavirus human coronavirus incidence infectious Infectious disease instance Lineage Lower respiratory tract microbe microbial molecular occur Patient PCR assay reductions in respiratory tract risk of infection significantly specimens strain virus viruses [DOI] 10.1016/j.jcv.2005.09.008 PMC 바로가기 [Article Type] Article
What Internet Services Would Patients Like From Hospitals During an Epidemic? Lessons From the SARS Outbreak in TorontoOriginal Paper Published on 2005-08-032022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome affected age Analysis Care clinics communicable diseases, emerging conducted Descriptive statistics determine emergency situation English Epidemic expressed Health health condition health information Health Service help hospital identify IMPROVE infectious Infectious disease information information services international health Internet Laboratory lesson Like logistic regression model maintain mean Most patient objective organization outbreak pandemic Patient predictor professional promote provided public health Questionnaires Regression responsible restrict Result searched selected service Severe acute respiratory syndrome Toronto unique Web were used World wide web [DOI] 10.2196/jmir.7.4.e46 PMC 바로가기 [Article Type] Original Paper
Molecular advances in the cell biology of SARS-CoV and current disease prevention strategiesReview Published on 2005-04-152022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Antiviral antivirals Author cDNA Cell Cell Biology clone disease elicit highlight host cell infectious interact molecular molecular virology Neutralizing antibodies receptor SARS-CoV SARS-CoV vaccine the disease the SARS epidemic Vaccines Viral antigen viral genome viral genome sequence [DOI] 10.1186/1743-422X-2-35 PMC 바로가기 [Article Type] Review
Coronavirus IBV: Partial amino terminal sequencing of spike polypeptide S2 identifies the sequence Arg-Arg-Phe-Arg-Arg at the cleavage site of the spike precursor propolypeptide of IBV strains Beaudette and M41Article Published on 2002-11-122022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Amino acid Analysis blocked bronchitis chymotrypsin cleavage cleavage site coronavirus coronavirus IBV determined Frame IBV identify in vivo infectious leucine M41 membrane N-terminal N-terminus nucleocapsid nucleotide sequence Partial peptide performed precursor propolypeptide protein sequencing related removed residue S1 and S2 sequence Sequencing Serine spike Spike protein strain trypsin Vero Cell Virus spike [DOI] 10.1016/0168-1702(86)90037-7 PMC 바로가기 [Article Type] Article