inherent – Page 16 – Communicable Diseases Research

Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19

Short communication

Published on 2020-10-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 신약개발, 치료제,

[키워드] a potassium ion channel in heart ACCdrug accumulation accumulate accumulating acid/base ionisation constant addition antiviral activity antiviral effects antivirals applied approach assessments available data C-C chemokine receptor type 5 CADcationic amphiphilic drug cationic amphiphilic drug CCR5C-C chemokine receptor type 5 cells clinical trial combating Compound Coronaviruses COVID-19 COVID-19 pandemic criteria disease displaying distribution coefficient of non-charged species of compound between octanol and water drug drug accumulation drugs endoplasmatic reticulum endosomal pathway endosome Endosomes ERendoplasmatic reticulum Evidence example help hERGhuman Ether-à-go-go-Related Gene highest human Ether-à-go-go-Related Gene identify in silico inherent interfere knowledge logPdistribution coefficient of non-charged species of compound between octanol and water lysosome Lysosomes membrane molecular outbreak Patient pharmacokinetic Phospholipidosis physicochemical pKaacid/base ionisation constant PLDphospholipidosis QSARquantitative structure activity relationship quantitative structure activity relationship Registered reported Spread Support tested Vdvolume of distribution viral infection volume of distribution
[DOI] 10.1016/j.biopha.2020.110582 [Article Type] Short communication

Repurposing existing drugs for COVID-19: an endocrinology perspective

Correspondence

Published on 2020-09-292022-10-28
Journal: BMC Endocrine Disorders [Category] COVID-19, SARS,

[키워드] absence ACE inhibitor ACE2 affected Ageusia aging androgen angiotensin receptor blocker angiotensin-converting enzyme-2 Anosmia Anti-androgen ARB arthralgia assessment candidate caused Clinical effect clinical testing clinical trial coronavirus 2 correlated COVID-19 COVID-19 patient death description Dexamethasone diabetes drug drug treatment effective therapy Efficacy elicited Endocrine Evidence familiarity fatigue Fever Glucocorticoids heterogeneous Hospitalization hypertension include Infection inherent inhibitor lack less mechanical ventilation methodological Mild-to-moderate myalgia N-acetyl cysteine NAC obesity Other outcome pandemic patients Perspective public health systems RAAS reduce mortality reduction in repurposing Research researcher respiratory risk Safe safety profile SARS-CoV-2 severe COVID-19 severely ill patient Symptom target therapeutic options TMPRSS2 transmembrane serine protease while with COVID-19 worse prognosis
[DOI] 10.1186/s12902-020-00626-0 PMC 바로가기 [Article Type] Correspondence

COVID‐19 and cardiac surgery: The perspective from United Kingdom

Review Article

Published on 2020-09-272022-10-30
Journal: Journal of cardiac surgery [Category] COVID-19, SARS,

TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients

Research

Published on 2020-09-232022-10-29
Journal: Journal of Experimental & Clinical Cancer Research : CR [Category] COVID-19, SARS,

Pandæsim: An Epidemic Spreading Stochastic Simulator

Article

Published on 2020-09-182022-10-28
Journal: Biology [Category] COVID-19,

Microstructures and dynamic processes within the five-phase system: regarding COVID-19 as a complex system

Research

Published on 2020-09-162022-10-31
Journal: Frontiers of Business Research in China [Category] COVID-19,

[키워드] aggregation Balancing feedback Chinese complex coronavirus disease (COVID-19) COVID-19 elements example FIVE Five-phase system inherent mechanism Microstructure promote provide Research Spiraling process Support
[DOI] 10.1186/s11782-020-00090-6 PMC 바로가기 [Article Type] Research

Evaluating approaches to designing effective Co-Created hand-hygiene interventions for children in India, Sierra Leone and the UK

Research Article

Published on 2020-09-152022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS, SARS,

[키워드] analysed approach children country COVID-19 disease Ebola effective element evaluate Evaluating Final FIVE global pandemic implication India inherent international public health Intervention Local methodological outcome Pragmatic Prevent problems promote Qualitative questionnaire response risk thematic analysis Transmission white
[DOI] 10.1371/journal.pone.0239234 PMC 바로가기 [Article Type] Research Article

Mainstream reintegration of COVID-19 survivors and its implications for mental health care in Africa

Essay

Published on 2020-08-282022-10-28
Journal: The Pan African Medical Journal [Category] COVID-19, MERS, SARS,

Pulmonary embolism or thrombosis in ARDS COVID-19 patients: A French monocenter retrospective study

Research Article

Published on 2020-08-272022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

[키워드] administration angiography anticoagulation ARDS ARDS COVID-19 patient baseline blocker clinical feature Cohort coronavirus disease COVID-19 COVID-19 patient Critically ill Critically ill patient diagnosed distal Doppler ultrasound embolic endotheliopathy French ICU increased risk inherent invasive mechanical lobar Local lower limb median Mortality MOST outcome parenchymatous Patient patients patients with PE patients without PE Prevalence prognostic proximal pulmonary Pulmonary embolism quartile reported respiratory Retrospective study risk factor Sedation thrombosis Thrombus treated Venous thrombosis with COVID-19
[DOI] 10.1371/journal.pone.0238413 PMC 바로가기 [Article Type] Research Article

Real-world evaluation of a novel technology for quantitative simultaneous antibody detection against multiple SARS-CoV-2 antigens in a cohort of patients presenting with COVID-19 syndrome † †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0an01066a

Chemistry

Published on 2020-08-212022-10-28
Journal: The Analyst [Category] COVID-19, MERS, SARS,