Virus Infection and Systemic Inflammation: Lessons Learnt from COVID-19 and Beyond바이러스 감염 및 전신 염증: COVID-19 및 그 이후에서 배운 교훈Review Published on 2022-07-142022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response addition Antiviral Avian Influenza COVID-19 disease Effectiveness etiological agent facilitate high mortality highlight highly pathogenic highly pathogenic avian influenza human infection human infections immune immune responses immunomodulatory include Infection Inflammatory responses Influenza Influenza virus influenza viruses interferon lesson Local mechanism organ organ-specific pandemic Perturbation Replication respiratory respiratory infections responses responsible SARS-CoV-2 severe disease similarity systemic systemic inflammation target organ therapeutic strategy viral infection viral replication viral spread virus zoonotic [DOI] 10.3390/cells11142198 PMC 바로가기 [Article Type] Review
Clinical, laboratory data and inflammatory biomarkers at baseline as early discharge predictors in hospitalized SARS-CoV-2 infected patients입원한 SARS-CoV-2 감염 환자의 조기 퇴원 예측인자로 기준선에서의 임상, 실험실 데이터 및 염증성 바이오마커Article Published on 2022-07-142022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Admission AUC baseline Beta C-reactive protein category CD25 clinical collected Corticosteroid Corticosteroids cytokine Cytokines D-dimers dehydrogenase Determination discharge discharged Factor group help hospital Hospitalization Hospitalized hospitals identify IMPROVE independent Inflammatory Inflammatory biomarker interferon interleukin laboratory data laboratory parameter Lactate lactate dehydrogenase logistic regression models Macrophage Male sex Mild mild patient mild patients Negative predictive value neutrophil NLR not need NPV oxygen oxygen saturation Oxygen therapy Patient performed plasma plasma sample plasma samples Positive predictive value PPV predict Predictive Predictive value predictor pro-inflammatory cytokine pro-inflammatory cytokines Protein receptor Regression model SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV-2 pandemic sensitivity severity Spanish specificity Transmission Treatment variable virus worsening [DOI] 10.1371/journal.pone.0269875 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or γδ T cellsSARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질은 인간 수지상 세포 또는 γδ T 세포를 활성화하지 못합니다Article Published on 2022-07-142022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activate activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 CD3+ cell co-cultured contribute coronavirus COVID-19 patient COVID-19 patients Cytokines dendritic cell dendritic cells digestion downstream flow cytometry healthy donors immune immune cells Immunity indicated induce interferon interferon-γ interleukin-12 investigated Ligand mechanism mononuclear cell mononuclear cells nucleocapsid nucleocapsid protein Nucleocapsid proteins protease Protein SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus stimulated stimulatory structural protein structural proteins T cell T cell activation T cells thought Viral RNA virus [DOI] 10.1371/journal.pone.0271463 PMC 바로가기 [Article Type] Article
Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity1년 동안 SARS-CoV-2-특이적 T 세포 사이토카인 생성 반응에 대한 종단 평가는 질병 중증도와 관련된 더 큰 면역과 함께 다중 사이토카인 증식 반응의 지속성을 보여줍니다Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all subjects assessment average CD4 CD8 Cell Cell-mediated immunity clone coronavirus Coronaviruses Critical cytokine cytokine response Cytokines declined demonstrated dominant ELISPOT ELISpot assay envelope enzyme-linked immunosorbent epitope Epitopes Ex vivo female Frequency gamma interferon granzyme B greater GzmB highlight IFN-γ IL-2 immune immune modeling. Immunity immunodominant immunodominant epitope immunodominant epitopes induce Infection interferon interleukin interleukin 2 kill longitudinal male median membrane nucleocapsid observation other coronaviruses peaked persistence post-symptom onset potent predicted produced producing proliferative PSO reduced regions response robust SARS-CoV-1 SARS-CoV-2 seasonal coronavirus seasonal coronaviruses severe acute respiratory syndrome Coronavirus severe disease structural protein structural proteins subject survivor T cell T cell immunity T cell memory T cell response T cell responses T cells target cells Vaccine viral infections Year [DOI] 10.1128/jvi.00509-22 PMC 바로가기 [Article Type] Article
Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-ε and -ωSARS-CoV-2에 대한 국소 인터페론 반응의 연령별 비교는 IFN-ε 및 -ω에 대한 역할을 제안합니다Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated Adults age anti-SARS-CoV-2 basal Basal transcription characterized children component components contribute develop diagnostic disease effective expression Genes highest Hospitalization IFN IFN response IFN-stimulated genes IFN-α IFN-ε IFN-λ1 IFN-ω IFNs individual infected individuals Infection Innate immunity interferon ISG ISG15 ISGs Mild Mild disease nasopharyngeal cell nasopharyngeal cells non-infected Occurrence Older overexpressed Protective quantified recent recognize relative expression response resulting risk role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individuals severe COVID-19 significantly higher starting swabs Symptom Transcription transcriptomic analysis type I type I and III IFNs type I interferon type III up-regulated [DOI] 10.3389/fimmu.2022.873232 PMC 바로가기 [Article Type] Article
Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19Review Published on 2022-07-122022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread [DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review
Immunogenicity and Reactogenicity of Ad26.COV2.S in Korean Adults: A Prospective Cohort Study한국 성인에서 Ad26.COV2.S의 면역원성과 반응성: 전향적 코호트 연구Article Published on 2022-07-112022-09-11 Journal: Journal of Korean medical science [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26 Ad26.COV2.S Adenovirus Adenovirus Vector Adverse adverse event adverse events AEs anti-S IgG Anti-spike baseline cellular immunity conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease Delta Dilution enrolled enzyme enzyme-linked immunospot assay evaluated fatigue Fever followed by geometric mean geometric mean titers GMT GMTs GRADE Humoral immunity IgG antibody immunogenic immunogenicity injection site pain interferon interferon-γ Korean mononuclear cell MOST myalgia NAb titer Neutralizing Neutralizing activity neutralizing antibody responses omicron Omicron variant Omicron variants outcome pandemic participant Peripheral blood Prospective prospective cohort study resolved respiratory Safe SARS-CoV-2 serious AEs severe acute respiratory syndrome Coronavirus Single-dose South Korea T-cell immunity T-cell Response T-cell responses the median U/mL university hospital vaccination Vaccines variant variants Viral Viral variants waning immunity wild-type WT SARS-CoV-2 [DOI] 10.3346/jkms.2022.37.e210 PMC 바로가기 [Article Type] Article
EWAS of post-COVID-19 patients shows methylation differences in the immune-response associated gene, IFI44L, three months after COVID-19 infectionObservational Study Published on 2022-07-072022-10-04 Journal: Scientific Reports [Category] 임상, 진단, 치료기술, 치료법, [키워드] Analysis ANKRD9 cellular processes Control Corona COVID-19 COVID-19 case COVID-19 infection Degradation DNA methylation Epigenetic FDR IFI44L IMPDH2 implicated innate response interferon investigated involved lack limitation long-COVID Methylation Ontology pathophysiology pathway Patient performed Peripheral blood positive individuals post-COVID-19 patient Post-infection predict profile Prognosis prospective observational study Sample size severity significant difference significantly Support Systemic autoimmune diseases therapeutic target variety viral infection viruses [DOI] 10.1038/s41598-022-15467-1 PMC 바로가기 [Article Type] Observational Study
Immune-based therapeutic approaches in COVID-19COVID-19의 면역 기반 치료 접근법Review Published on 2022-07-012022-09-12 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome antibodies approach ARDS caused Complication coronavirus Coronavirus disease 2019 Coronavirus-2 Corticosteroids COVID-19 COVID-19 pathogenesis COVID-19 research Cytokine storm syndrome eliminating Epidemic immune immune system Immunotherapy interferon Intravenous immunoglobulin IVIG measure monoclonal antibody not applicable pandemic pathogen physical Pneumonia SARS SARS-CoV-2 social distancing the Coronaviridae the disease Therapeutic approach therapy Treatment vaccination viral disease WHO World Health Organization [DOI] 10.1016/j.biopha.2022.113107 PMC 바로가기 [Article Type] Review
Regulation of IFNα-induced expression of the short ACE2 isoform by ULK1Article Published on 2022-07-012023-07-09 Journal: Molecular immunology [Category] COVID19(2023년), [키워드] ACE2 DeltaACE2 Fisetin interferon Short ACE2 ULK1. [DOI] 10.1016/j.molimm.2022.04.008 PMC 바로가기